1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins

Biochemical and Biophysical Research Communications

Volumn 360, Issue 1, 2007, Pages 290-294

  Soininen, Pasi ^a   Öörni, Katariina ^b   Maaheimo, Hannu ^c   Laatikainen, Reino ^a   Kovanen, Petri T ^b   Kaski, Kimmo ^d   Ala Korpela, Mika ^d  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b WIHURI RESEARCH INSTITUTE   (Finland)

^c Biophysics Program   (Finland)

^d AALTO UNIVERSITY   (Finland)

Author keywords

Atherosclerosis; LDL; Lipid peroxidation; Lipoprotein accumulation; Lipoprotein modifications; Lipoprotein associated phospholipase A2; Lipoproteins; Lysophosphatidylcholine; NMR spectroscopy; Phosphatidylcholine; Phospholipase A2; Sphingomyelin

Indexed keywords

LOW DENSITY LIPOPROTEIN; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; SPHINGOMYELIN; PROTON;

ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; FOLLOW UP; HUMAN; LIPID PEROXIDATION; NORMAL HUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; ATHEROSCLEROSIS; CHEMISTRY; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ATHEROSCLEROSIS; HUMANS; LIPOPROTEINS, LDL; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPIDS; PROTONS;

EID: 34250876293     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.06.058     Document Type: Article

References (27)

1. Hevonoja T., Pentikäinen M.O., Hyvönen M.T., Kovanen P.T., and Ala-Korpela M. Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL. Biochim. Biophys. Acta 1488 (2000) 189-210
2. Öörni K., Pentikäinen M.O., Ala-Korpela M., and Kovanen P.T. Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions. J. Lipid Res. 41 (2000) 1703-1714
3. Williams K.J., and Tabas I. The response-to-retention hypothesis of atherogenesis reinforced. Curr. Opin. Lipidol. 9 (1998) 471-474
4. Sneck M., Kovanen P.T., and Öörni K. Decrease in pH strongly enhances binding of native, proteolyzed, lipolyzed, and oxidized low density lipoprotein particles to human aortic proteoglycans. J. Biol. Chem. 280 (2005) 37449-37454
5. Pentikäinen M.O., Hyvönen M.T., Öörni K., Hevonoja T., Korhonen A., Lehtonen-Smeds E.M., Ala-Korpela M., and Kovanen P.T. Altered phospholipid-apoB-100 interactions and generation of extra membrane material in proteolysis-induced fusion of LDL particles. J. Lipid Res. 42 (2001) 916-922
6. Segrest J.P., Jones M.K., De Loof H., and Dashti N. Structure of apolipoprotein B-100 in low density lipoproteins. J. Lipid Res. 42 (2001) 1346-1367
7. Hamilton J.A., and Morrisett J.D. Nuclear magnetic resonance studies of lipoproteins. Methods Enzymol. 128 (1986) 472-515
8. Ala-Korpela M., Pentikäinen M.O., Korhonen A., Hevonoja T., Lounila J., and Kovanen P.T. Detection of low density lipoprotein particle fusion by proton nuclear magnetic resonance spectroscopy. J. Lipid Res. 39 (1998) 1705-1712
9. Murphy H.C., Ala-Korpela M., White J.J., Raoof A., Bell J.D., Barnard M.L., Burns S.P., and Iles R.A. Evidence for distinct behaviour of phosphatidylcholine and sphingomyelin at the low density lipoprotein surface. Biochem. Biophys. Res. Commun. 234 (1997) 733-737
10. 1H nuclear magnetic resonance spectroscopy: mobility of phosphatidylcholine and sphingomyelin headgroups characterizes the surface layer. Biochemistry 39 (2000) 9763-9770
11. Mahley R.W., Weisgraber K.H., and Innerarity T.L. Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors. Biochim. Biophys. Acta 575 (1979) 81-91
12. Radding C.M., and Steinberg D. Studies on the synthesis and secretion of serum lipoproteins by rat liver slices. J. Clin. Invest. 39 (1960) 1560-1569
13. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
14. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37 (1959) 911-917
15. Hessler J.R., Morel D.W., Lewis L.J., and Chisolm G.M. Lipoprotein oxidation and lipoprotein-induced cytotoxicity. Arteriosclerosis 3 (1983) 215-222
16. 13C enriched metabolites from cell suspensions incubated in deuterated media. Magn. Reson. Med. 36 (1996) 359-365
17. 1H NMR spectroscopy: Constrained total-line-shape fitting. Anal. Chim. Acta 542 (2005) 178-185
18. Mierisova S., and Ala-Korpela M. MR spectroscopy quantitation: a review of frequency domain methods. NMR Biomed. 14 (2001) 247-259
19. 2 and the effect of atorvastatin treatment, Atherosclerosis, in press, doi:10.1016/j.atherosclerosis.2006.10.033.
20. Esterbauer H., Gebicki J., Puhl H., and Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic. Biol. Med. 13 (1992) 341-390
21. 2 in atherosclerosis: biology, epidemiology, and possible therapeutic target. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 923-931
22. 2+-induced oxidation in relation to changes in lipid composition. Biochem. J. 319 (1996) 217-227
23. Liu S.Y., Lu X., Choy S., Dembinski T.C., Hatch G.M., Mymin D., Shen X., Angel A., Choy P.C., and Man R.Y. Alteration of lysophosphatidylcholine content in low density lipoprotein after oxidative modification: relationship to endothelium dependent relaxation. Cardiovasc. Res. 28 (1994) 1476-1481
24. Lodge J.K., Sadler P.J., Kus M.L., and Winyard P.G. Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. Biochim. Biophys. Acta 1256 (1995) 130-140
25. 2 as a biomarker for coronary disease and stroke. Nat. Clin. Pract. Cardiovasc. Med. 2 (2005) 529-535
26. Memon R.A., Staprans I., Noor M., Holleran W.M., Uchida Y., Moser A.H., Feingold K.R., and Grunfeld C. Infection and inflammation induce LDL oxidation in vivo. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 1536-1542
27. Rosenblat M., Oren R., and Aviram M. Lysophosphatidylcholine (LPC) attenuates macrophage-mediated oxidation of LDL. Biochem. Biophys. Res. Commun. 344 (2006) 1271-1277