Potassium channel opener pinacidil induces relaxation of the isolated human radial artery

Journal of Pharmacological Sciences

Volumn 104, Issue 2, 2007, Pages 122-129

  Stojnic, Natasa ^a   Gojkovic Bukarica, Ljiljana ^a   Peric, Miodrag ^b   Grbovic, Leposava ^a   Lesic, Aleksandar ^c   Bumbasirevic, Marko ^c   Heinle, Helmut ^d  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Institute for Cardiovascular Diseases Dedinje   (Serbia)

^c CLINICAL CENTER OF SERBIA   (Serbia)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Human radial artery; K+ channel; Na+ Ca 2+ exchanger; Pinacidil

Indexed keywords

4 AMINOPYRIDINE; CHARYBDOTOXIN; GLIBENCLAMIDE; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; NICKEL; NIFEDIPINE; PHENYLEPHRINE; PINACIDIL; POTASSIUM; POTASSIUM CHANNEL STIMULATING AGENT; TETRYLAMMONIUM;

ADULT; ARTERY DILATATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; ENDOTHELIUM; HUMAN; HUMAN TISSUE; ISOLATED ARTERY; MALE; RADIAL ARTERY; SHIFT TO THE RIGHT; SMOOTH MUSCLE RELAXATION; SODIUM CALCIUM EXCHANGE; STATISTICAL SIGNIFICANCE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 34250836835     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0061434     Document Type: Article

References (32)

1. Lytle BW. Prolonging patency - choosing coronary bypass grafts. N Engl J Med. 2004;351:2262-2264.
2. Downing SW, Edmunds LH Jr. Release of vasoactive substances during cardiopulmonary bypass. Ann Thorac Surg. 1992;54:1236-1243.
3. Stojnic N, Bukarica LG, Peric M, Bumbasirevic M, Lesic A, Lipkovski JM, et al. Analysis of vasoreactivity of isolated human radial artery. J Pharmacol Sci. 2006;100:34-40.
4. Iwaki M, Mizobuchi S, Nakaya Y, Kawano K, Niki T, Mori H. Tetraethylammonium induced coronary spasm in isolated perfused rabbit heart: a hypothesis for the mechanism of coronary spasm. Cardiovasc Res. 1987;21:130-139.
5. He GW, Yang CQ, Starr A. Overview of the nature of vasoconstriction in arterial grafts for coronary operations. Ann Thorac Surg. 1995;59:676-683.
6. Yang Q, He GW. Effect of cardioplegic and organ preservation solutions and their components on coronary endothelium-derived relaxing factors. Ann Thorac Surg. 2005;80:757-767.
7. Sadaba JR, Mathew K, Munsch CM, Beech DJ. Vasorelaxant properties of nicorandil on human radial artery. Eur J Cardiothorac Surg. 2000;17:319-324.
8. Hamilton CA, O'Dowd GO, McIntosh L, Berg G, Butler J, Pathi V, et al. Vasorelaxant properties of isolated human radial arteries: comparison with internal mammary arteries. Atherosclerosis. 2002;160:345-353.
9. Bray KM, Newgreen DT, Small RC, Southerton JS, Taylor SG, Weir SW, et al. Evidence that the mechanism of the inhibitory action of pinacidil in rat and guinea-pig smooth muscle differs from that glyceril trinitrate. Br J Pharmacol. 1987;91:421-429.
10. + channels? Trends Pharmacol Sci. 1993;14:332-337.
11. Gojkovic Bukarica L, Kazic T, Sajic Z, Djukanovic B, Panic G, Peric M, et al. The effects of levcromakalim and pinacidil on the human internal mammary artery. Fundam Clin Pharmacol. 1997;11:550-560.
12. Ghaleh B, Dubois-Rande JL, Hittinger L, Giudicelli JF, Berdeaux A. Comparison of the effect of nicorandil, pinacidil, nicardipine and nitroglycerin on coronary vessels in the conscious dog: role of endothelium. Br J Pharmacol. 1995;114:496-502.
13. Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995;275:681-692.
14. + channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats. Eur J Pharmacol. 1999;365:241-251.
15. Schaffer P, Pelzmann B, Bernhart E, Lang P, Machler H, Rigler B, et al. The sulphonylurea glibenclamide inhibits voltage dependent potassium currents in human atrial and ventricular myocytes. Br J Pharmacol. 1999;128:1175-1180.
16. Satoh K, Yamada H, Taira N. Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries. Naunyn Schmiedebergs Arch Pharmacol. 1991;343:76-82.
17. + channels in human coronary artery vascular smooth muscle cells. Am J Physiol. 1997;273:C161-C171.
18. Gojkovic L, Kazic T. A comparison of the relaxant effects of pinacidil in rabbit renal and mesenteric artery. Gen Pharmacol. 1994;25:1711-1717.
19. Lattore R, The large calcium-activated potassium channel. In: Miller C, editor. Ion channel reconstruction. New York: Plenum Press; 1986. p. 431-467.
20. Alexander SPH, Mathie A, Peters JA. Guide to receptors and channels, 2nd ed. Br J Pharmacol. 2006;147 Suppl 3:S1-S180.
21. Suarez-Kurtz G, Vianna-Jorge R, Pereira BF, Garcia ML, Kaczorowski GJ. Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release. J Pharmacol Exp Ther. 1999;289:1517-1522.
22. + channel in porcine coronary endothelium: relevance to EDHF. Br J Pharmacol. 2002;137:1346-1354.
23. Tamargo J, Caballero R, Gomez R, Valenzuela C, Delpon E. Pharmacology of cardiac potassium channels. Cardiovasc Res. 2004;62:9-33.
24. 2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery. Br J Pharmacol. 2003;138:453-460.
25. Cai B, Hao Q, Greenberg SS, deBoisblanc B, Gillott D, Goharderakhshan R, et al. Differential effects of pinacidil and cromakalim on vascular relaxation and sympathetic neurotransmission. Can J Physiol Pharmacol. 1994;72:801-810.
26. Itoh T, Seki N, Suzuki S, Ito S, Kajikuri J, Kuriyama H. Membrane hyperpolarization inhibits agonist-induced synthesis of inositol 1,4,5-trisphosphate in rabbit mesenteric artery. J Physiol. 1992;451:307-328.
27. 2+ release in coronary artery. Cardiovasc Drugs Ther. 1993;7:565-574.
28. Xiong ZL, Kajioka S, Sakai T, Kitamura K, Kuriyama H. Pinacidil inhibits the ryanodine-sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein. Br J Pharmacol. 1991;102:788-790.
29. 2+ exchanger isoforms by divalent cations and isothiourea derivative. Am J Physiol. 1998;275:C423-C430.
30. Petkov GV, Fusi F, Saponara S, Gagov HS, Sgaragli GP, Boev KK. Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery. Acta Physiol Scand. 2001;173:257-265.
31. Schweda F, Kramer BK, Kurtz A. Differential roles of the sodium-calcium exchanger in renin secretion and renal vascular resistance. Pflugers Arch. 2001;442:693-699.
32. + channel-dependent as well as -independent components of pinacidil-induced vasodilation. J Pharmacol Exp Ther. 1991;256:492-499.