The heterotrimeric G protein Gi3 regulates hepatic autophagy downstream of the insulin receptor

Autophagy

Volumn 3, Issue 4, 2007, Pages 393-395

  Gohla, Antje ^a   Klement, Karinna ^a   Nürnberg, Bernd ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Autophagy; G i3; G proteins on endomembranes; Insulin; Mouse knockout; mTOR; Pertussis toxin sensitive G proteins

Indexed keywords

AMINO ACID; CELL PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHENYLALANINE; PROTEIN TYROSINE KINASE;

ARTICLE; AUTOPHAGY; CELL MEMBRANE; CELL ORGANELLE; ENDOCRINE FUNCTION; ENZYME MEMBRANE BIOREACTOR; HORMONE ACTION; LIVER; NONHUMAN; PATHOLOGY; PHAGOSOME; PHYSIOLOGY; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

EID: 34250834360     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.4256     Document Type: Article

References (30)

1. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15:1101-11.
2. Mortimore GE, Schworer CM. Induction of autophagy by amino acid-deprivation in perfused rat liver. Nature 1977; 270:174-6.
3. Meijer AP, Codogno P. Signalling and autophagy regulation in health, aging and disease. Mol Aspects Med 2006; 27:411-25.
4. Kadowaki M, Venerando R, Miotto G, Mortimore GE. De novo autophagic vacuole formation in hepatocytes permeabilized by Staphylococcus aureus α-toxin. Inhibition by non-hydrolyzable GTP analogs. J Biol Chem 1994; 269:3703-10.
5. i3-protein controls autophagic sequestration in the human colon cancer cell line HT-29. J Biol Chem 1995; 270:13-6.
6. i3 protein controls autophagic sequestration in HT-29 cells. J Biol Chem 1996; 271:28593-600.
7. i-proteins. Biochem J 2004; 380:831-6.
8. Birnbaumer L. Expansion of signal transduction by G proteins: The second 15 years or so: From 3 to 16 α subunits plus βγ dimers. Biochim Biophys Acta 2007; 1768:772-93.
9. i2-deficient mice. Nat Genet 1995; 10:143-50.
10. 1 constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation. Neuron 2004; 41:153-63.
11. i2 activation that controls C5aR and Fc receptor cooperation. J Immunol 2005; 174:3041-50.
12. i proteins. Am J Physiol Cell Physiol 2005; 289:C293-301.
13. i3 in the antiautophagic action of insulin in the liver. Proc Natl Acad Sci USA 2007; 104:3003-8.
14. Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-84.
15. Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol 2005; 17:596-603.
16. Shintani T, Klionsky DJ. Autophagy in health and disease: A double-edged sword. Science 2004; 306:990-5.
17. Nürnberg B, Ahnert-Hilger G. Potential roles of heterotrimeric G proteins of the endomembrane system. FEBS Lett 1996; 389:61-5.
18. Denker SP, McCaffery JM, Palade GE, Insel PA, Farquhar MG. Differential distribution of a subunits and βγ subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. J Cell Biol 1996; 133:1027-40.
19. i families localized at the Golgi membrane. Biochem Biophys Res Commun 1995; 208:135-45.
20. Sallese M, Pulvirenti T, Luini A. The physiology of membrane transport and endomembrane-based signaling. EMBO J 2006; 25:2663-73.
21. i3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells. J Cell Biol 1991; 114:1113-24.
22. Stow JL, de Almeida JB. Distribution and role of heterotrimeric G proteins in the secretory pathway of polarized epithelial cells. J Cell Sci Suppl 1993; 17:33-9.
23. Wilson BS, Komuro M, Farquhar MG. Cellular variations in heterotrimeric G protein localization and expression in rat pituitary. Endocrinology 1994; 134:233-44.
24. i acrivity in diabetes. Nature 1987; 327:229-32.
25. 2. Nature 1996; 379:840-4.
26. i2 in vivo mimics insulin action. J Mol Med 1997; 75:283-9.
27. i2 enhances in vivo activation of and insulin signaling to GLUT4. J Biol Chem 2001; 276:34651-8.
28. Cuervo AM. Autophagy: In sickness and in health. Trends Cell Biol 2004; 14:70-77.
29. Deretic V. Autophagy in innate and adaptive immunity. Trends Immunol 2005; 26:523-8.
30. Levine B. Unraveling the role of autophagy in cancer. Autophagy 2006; 2:65-6.