Hemin, an inducer of heme oxygenase-1, lowers intraocular pressure in rabbits

Journal of Ocular Pharmacology and Therapeutics

Volumn 23, Issue 3, 2007, Pages 232-239

  Privitera, Maria G ^a   Potenza, Marta ^b   Bucolo, Claudio ^a   Leggio, Gian M ^a   Drago, Filippo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE SODIUM PHOSPHATE; CARBON MONOXIDE; CHYMOTRYPSIN A; HEME OXYGENASE 1; HEMIN; PROTOPORPHYRIN ZINC; UNCLASSIFIED DRUG; ZINC PROTOPORPHYRIN IX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MALE; NONHUMAN; PUPIL; RABBIT;

ANALYSIS OF VARIANCE; ANIMALS; BETAMETHASONE; CHYMOTRYPSIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; HEME OXYGENASE-1; HEMIN; INJECTIONS, INTRAVENOUS; INTRAOCULAR PRESSURE; MALE; OCULAR HYPERTENSION; PROTOPORPHYRINS; RABBITS; RANDOM ALLOCATION;

EID: 34250828977     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2006.101     Document Type: Article

References (40)

1. Motterlini, R., Gonzales, A., Foresti, R., et al. Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo. Circ. Res. 83:568-577, 1998.
2. Durante, W., and Schafer, A.I. Carbon monoxide and vascular cell function. Int. J. Mol. Med. 2:255-262, 1998.
3. Clark, J.E., Foresti, R., Sarathchandra, P., et al. Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction. Am. J. Physiol. 278: 643-651, 2000.
4. Maines, M.D., Trakshel, G.M., and Kutty, R.K. Characterization of two constitutive forms of rat liver microsomal heme oxygenase: Only one molecular species of the enzyme is inducible. J. Biol. Chem. 261: 411-419, 1986.
5. Shibahara, S., Muller, R., Taguchi, H., et al. Cloning and expression of cDNA for rat heme oxygenase. Proc. Natl. Acad. Sci. USA 82:7865-7869, 1985.
6. McCoubrey, W.K., Jr., Huang, T.J., and Maines, M.D. Isolation and characterization of a cDNA from the rat brain that encodes hemeprotein heme oxygenase-3. Eur. J. Biochem. 247:725-732, 1997.
7. Martasek, P., Schwartzman, M.L., Goodman, A.I., et al. Hemin and L-arginine regulation of blood pressure in spontaneous hypertensive rats. J. Am. Soc. Nephrol. 2:1078-1084, 1991.
8. Cao, L., and Eldred, W.D. Inhibitors of nitric oxide synthase block carbon monoxide-induced increases in cGMP in retina. Brain Res. 988:78-83, 2003.
9. Cao, L., Blute, T.A., and Eldred, W.D. Localization of heme oxygenase-2 and modulation of cGMP levels by carbon monoxide and/or nitric oxide in the retina. Vis. Neurosci. 17:319-329, 2000.
10. Chang, K.-H, Afzal, A., LiCalzi, S., et al. Nitric oxide (NO) and carbon monoxide (CO) regulate vasodilator-stimulated phosphoprotein (VASP), a key cytoskeletal protein involved in endothelial progenitor cell (EPC) migration. Presented at the 2006 ARVO Meeting, April 30,2006-May 4,2006, Fort Lauderdale, Florida, Abstract 1710.
11. Gaun, S., Ohta, K., Kikuchi, T., et al. Protective role of heme oxygenase-1 on retinal ischemia-reperfusion injury in rats. Presented at the 2002 ARVO Meeting, May 5, 2002-May 10, 2002, Fort Lauderdale, Florida, Abstract 662.
12. Ohta, K., Kikuchi, T., Arai, S., et al. Protective role of heme oxygenase-1 against endotoxin-induced uveitis in rats. Exp. Eye Res. 77:665-673, 2003.
13. Liu, R., Flammer, J., and Haeflinger, I.O. Isoproterenol, forskolin, and cAMP-induced nitric oxide production in pig ciliary processes. Invest. Ophthalmol. Vis. Sci. 40:1833-1837, 1999.
14. Mayer, P., Champion, C., Schlotzer-Schrehardt, U., et al. Localization of nitric oxide synthase isoforms in porcine ocular tissues. Curr. Eye Res. 18:375-380, 1999.
15. Fleischhauer, J.C., Beny, J.L., Flammer, J., et al. NO/cGMP pathway activation and membrane potential depolarization in pig ciliary epithelium. Invest. Ophthalmol. Vis. Sci. 41:1759-1763, 2000.
16. Taniguchi, T., Kawakami, H., Sawada, A., et al. Effects of nitric oxide synthase inhibitor on intraocular pressure and ocular inflammation following laser irradiation in rabbits. Curr. Eye Res. 17: 308-315, 1998.
17. Kiel, J.W. Modulation of choroidal autoregulation in the rabbit. Exp. Eye Res. 69:413-429, 1999.
18. Giuffrida, S., Bucolo, C., and Drago, F. Topical application of a nitric oxide synthase inhibitor reduces intraocular pressure in rabbits with experimental glaucoma. J. Ocul. Pharmacol. Ther. 19:527-534, 2003.
19. Kiel, J.W., Reitsamer, H.A., Walker, J.S., et al. Effects of nitric oxide synthase inhibition on ciliary blood flow, aqueous production, and intraocular pressure. Exp. Eye Res. 73:355-364, 1999.
20. Drago, F., Emmi, I., and Marino, V. Effects of β-blockers association with pilocarpine on rabbit intraocular pressure and heart rate. Pharmacol. Res. 35:299-306, 1997.
21. McFarland, R.A. The effects of exposure to small quantities of carbon monoxide on vision. Ann. N.Y. Acad. Sci. 174:301-312, 1970.
22. Kelley, J.S., and Sophocleus, G.J. Retinal hemorrhages in subacute carbon monoxide poisoning: Exposures in homes with blocked furnace flues. JAMA 239: 1515-1517, 1978.
23. Maines, M.D. Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical application. FASEB J. 2:2557-2568, 1988.
24. Suematsu, M., Wakabayashi, Y., and Ishimura, Y. Gaseous monoxides: A new class of microvascular regulator in the liver. Cardiovasc. Res. 32:679-686, 1996.
25. Maines, M.D. The heme oxygenase system: A regulator of second messenger gases. Ann. Rev. Pharmacol. Toxicol. 37:517-554, 1997.
26. Siaw, R.C.M., Sato, H., and Mann, G.E. Heme oxygenase-carbon monoxide signaling pathway in atherosclerosis: Antiatherogenic actions of bilirubin and carbon dioxide? Cardiovasc. Res. 41:385-394, 1999.
27. Szabo, M.E., Gallyas, E., Bak, I., et al. Heme oxygenase-1-related carbon monoxide and flavonoids in ischemic-reperfused rat retina. Invest. Ophthalmol. Vis. Sci. 45:3727-3732, 2004.
28. Verma, A., Hirsch, D.J., Glatt, C.E., et al. Carbon monoxide: Putative neural messenger. Science 259: 381-384, 1993.
29. Nishimura, R.N., Dwyer, B.E., and Lu, S.-Y. Localization of heme oxygenase in rat retina: Effect of light adaptation. Neurosci. Lett. 205:13-16, 1996.
30. Ma, N., Ding, X., Doi, M., et al. Cellular and subcellular localization of heme oxygenase-2 in monkey retina. J. Neurocytol. 33:407-415, 2004.
31. Otterbein, L.E., Bach, F.H., Alam, J., et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat. Med. 6:422-428, 2000.
32. Lee, T.-S., and Chau, L.-Y. Heme oxygenase-1 mediates the anti-inflammatory effects of interleukin-10 in mice. Nat. Med. 8:240-246, 2002.
33. Hangaishi, M., Ishizaka, N., Aizawa, T., et al. Induction of heme oxygenase-1 act protectively against cardiac ischemia/reperfusion in vivo. Biochem. Biophys. Res. Commun. 279:582-588, 2000.
34. Taille, C., Foresti, R., Lanone, S., et al. Protective role of heme oxygenases against endotoxin-induced diaphragmatic dysfunction in rats. Am. J. Respir. Crit. Care Med. 163:753-761, 2001.
35. Behar-Cohen, F.F., Goureau, O., D'Hermies, F., et al. Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye. Invest. Ophthalmol. Vis. Sci. 37:1711-1715, 1996.
36. Kotikoski, H., Vapaatalo, H., and Oksala, O. Nitric oxide and cyclic GMP enhance aqueous humor outflow facility in rabbits. Curr. Eye Res. 26:119-123, 2003.
37. Larsson, L.I., Maus, T., Brubaker, R.F., et al. Topically applied hydralazine: Effects on systemic cardiovascular parameters, blood-aqueous barrier, and aqueous humor dynamics in normotensive hymans. J. Ocul. Pharmacol. Therapeut. 11:145-156, 1995.
38. Krupin, T., Weiss, A., Becker, B., et al. Increased intraocular pressure following topical azide or nitroprusside. Invest. Ophthalmol. Vis. Sci. 16:1002-1007, 1977.
39. Taniguchi, T., Kawakami, H., Sawada, A., et al. Effects of nitric oxide synthase inhibitor on intraocular pressure and ocular inflammation following laser irradiation in rabbits. Curr. Eye Res. 17:308-315, 1998.
40. Kiss, B., Dallinger, S., Findl, O., et al. Acetazolamide-induced cerebral and ocular vasodilation in humans is independent of nitric oxide. Am. J. Physiol. 276: R1661-R1667, 1999