Expression and significance of the protein and mRNA of metastasis suppressor gene Me491/cd63 and integrin α5 in ovarian cancer tissues

European Journal of Gynaecological Oncology

Volumn 28, Issue 3, 2007, Pages 179-183

  Zhijun, X ^a   Shulan, Z ^a   Zhuo, Z ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Integrin 5; ME491 CD63; Metastasis; Ovarian cancer

Indexed keywords

ALPHA5 INTEGRIN; CD63 ANTIGEN; MESSENGER RNA;

ADULT; ARTICLE; CANCER TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LYMPH NODE METASTASIS; OVARY CANCER; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPPRESSOR GENE; TUMOR DIFFERENTIATION;

ANTIGENS, CD; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRIN ALPHA5; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM STAGING; OVARIAN NEOPLASMS; PLATELET MEMBRANE GLYCOPROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34250818770     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. He B., Liu L., Cook G.A. et al.: "Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion". J. Biol. Chem., 2005, 280, 3346.
2. Zhou B., Liu L., Reddivari M. et al.: "The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility-and invasiveness-inhibitory activity". Cancer Res., 2004, 64, 7455.
3. Farhadieh R.D., Smee R., Ow K. et al.: "Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival". Cancer, Lett., 2004, 213, 91.
4. Schiller J.H., Bittner G.: "Loss of the tumorigenic phenotype with in vitro, but not in vivo, passaging of a novel series of human bronchial epithelial cell lines: possible role of an α5/β1-integrin-fibronectin interaction". Cancer Res., 1995, 55, 6215.
5. Hashida H., Takabayashi A., Tokuhara T. et al.: "Clinical significance of transmembrane 4 superfamily in colon cancer". Br. J. Cancer, 2003, 89, 158.
6. Hemler M.E., Mannion B.A., Berditchevski F.: "Association of TM4SF proteins with integrins : relevance to cancer". Biochim. Biophys. Acta, 1996, 128, 67.
7. Berditchevski F., Zutter M.M., Hemler M.E.: "Characterization of novel complexes on the cell urface between integrins and proteins with 4 transmembrane domains". Mol. Biol. Cell, 1996, 7, 193.
8. Kurose K., Zhou X.P., Araki T. et al.: "Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas". Am. J. Pathol., 2001, 158, 2097.
9. Jackson P., Millar D., Kingsley E. et al.: "Methylation of a CpG island within the promoter region of the KALL metastasis suppressor gene is not responsible for down-regulation of Kail expression in invasive cancers or cancer cell lines". Cancer Lett., 2000, 157, 169.
10. Mashimo T., Bandyopadhyay S., Goodarzi G. et al.: "Activation of the tumor metastasis suppressor gene, Kail, by etoposide is mediated by p53 and c-Jun genes". Biochem. Biophys. Res. Commun., 2000, 274, 370.
11. Duriez C., Falette N., Cortes U. et al.: "Absence of p53-dependent induction of metastatic suppressor Kail gene after DNA damage". Oncogene, 2000, 19, 2461.
12. Jiang B., Zhang Y., Zhou D.: "Common test methods in molecular biology". Beijing: People's Military Surgeon Publishing House, 1996, 128.