Grapefruit seed extract moderates morphologic, functional and biochemical evidence of epidoxorubicin-induced testicular toxicity

Journal of Medical Sciences

Volumn 7, Issue 4, 2007, Pages 650-654

  Saalu, L C ^a   Kpela, T ^a   Shittu, L A J ^a   Ashiru, O A ^a  

^a LAGOS STATE UNIVERSITY   (Nigeria)

Author keywords

Epidoxorubicin; Grapefruit seed extract; Rat; Testicular toxicity

Indexed keywords

ARACHIS OIL; EPIRUBICIN; GRAPEFRUIT SEED EXTRACT; MALONALDEHYDE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BODY WEIGHT; CONTROLLED STUDY; DECAPITATION; EPIDIDYMIS; GRAPEFRUIT; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MORPHOLOGY; NONHUMAN; PLANT SEED; RAT; REPRODUCTIVE TOXICITY; SINGLE DRUG DOSE; SPERMATOGENESIS; SPERMATOZOON MOTILITY; STATISTICAL SIGNIFICANCE; TESTIS; TESTIS FUNCTION; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL;

EID: 34250815057     PISSN: 16824474     EISSN: 18125727     Source Type: Journal    
DOI: 10.3923/jms.2007.650.654     Document Type: Article

References (17)

1. Atessahin, A., I. Karahan, G. Turk, S. Gur, S. Yilmaz and A.O. Ceribasi, 2006. Protective role of lycopene on cisplatin induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod Toxicol., 21: 42-47.
2. Dembinski, A. and T. Konturek, 2004. Extract of Grape fruit seed reduces acute pancreatitis induced by ischaemic/reperfusion in rats. Possible implication of tissue antioxidants. J. Physiol. Pharmacol., 55: 811-821.
3. Endo, F., F. Manabe, H. Takeshima and H. Akaza, 2003. Protecting spermatogonia from apoptosis induced by doxorubicine using the luteinizing hormone- releasing hormone analog leuprorelin. Int. J. Urol., 10: 72-77.
4. Howell, S.J. and S.M. Shalet, 2001. Testicular function following chemotherapy. Human Reprod Update, 7: 363-369.
5. Kalender, Y. and M. Yel, 2005. Doxorubicin hepatotoxicity and hepatic free radicals in rats. The effects of Vitamin E and Catechin. Toxicology, 209: 39-45.
6. Kato, M., S. Makino, H. Kimura and T. Ota, 2001. Sperm motion analysis in rats treated with adriamycin and its applicability to male reproductive toxicity studies. J. Toxicol. Sci., 26: 51-59.
7. Kirsi, T. and J. Timo, 2001. Toxic effects of epidoxorubicin. Cancer Res., 24: 634-644.
8. Mycet, M.J., R.A. Champe and R.A. Harvey, 1997. Pharmacology 2nd Edn., Lippincott-Raven Publishers, pp: 384-385.
9. Ohkawa, H., N. Ohishi and K. Yagi, 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95: 351-358.
10. Prahalaathan, C., E. Selvekuman and P. Varalakshmi, 2005. Lipoic acid ametiolates adriamycin induced testicular mitochondriopathy. Reprod. Tooxicol., 20: 111-116.
11. Quiles, J.L., J.R. Huertas and J. Matain, 2002. Antioxidant nutrients and adriamycin toxicity. Toxicology, 180: 79-95.
12. Saalu, L.C., V.A. Togun, A.O. Oyewopo and Y. Raji, 2006. Artificial cryptorchidism and the moderating effect of melatonin in Sprague-Dawley rats. J. Applied Sci., 6: 2889-2894.
13. Sachs, A., 1997. The Authoritative Guide to Grape Fruit Seed Extract, Stay Healthy Naturally, Liferhythm, Medocino, California, pp: 775-795.
14. Sikka, S.C., 1996. Oxidative stress and role of antioxidants in normal and abnormal sperm function. Front Biol. Sci., 1: 78-86.
15. Sonmez, M., G. Turk and K. Yagi, 2005. The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wister rats. Theriogenology, 63: 2063-2072.
16. Suominen, J.S.J. Linderborg, H. Nikula, H. Hakovirta and M. Parvinen, 2003. The effects of mono-2-ethexyphathalate, adriamycin and N-ethyl-N-Nitrosourea on stage specific apoptosis and DNA synthesis in the mouse spermatogenesis. Toxicol. Lett., 143: 163-173.
17. Teicher, B.A., J.L. Schwartz and S.A. Holden, 1994. In vivo modulation of several anticancer agents by β-carotone. Cancer Chemother. Phamacol., 34: 235-241.