Effect of chronic stress and L-carnitine on rat stomach

Journal of Physiological Sciences

Volumn 57, Issue 3, 2007, Pages 187-192

  Izgüt Uysal, V Nimet ^a   Bülbül, Mehmet ^a   Tan, Ruken ^a   Derin, Narin ^a   Üstünel, Ismail ^a   Aǧar, Aysel ^a   Yargiçoǧlu, Piraye ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Gastric injury; L carnitine; Lipid peroxidation; Restraint stress

Indexed keywords

CARNITINE; CATALASE; PROSTAGLANDIN E2; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; DISEASE MARKER; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME RELEASE; LIPID PEROXIDATION; MALE; MUCUS SECRETION; NONHUMAN; RAT; STOMACH MUCOSA LESION; STOMACH MUCUS;

ANIMALS; CARNITINE; CATALASE; DINOPROSTONE; GASTRIC MUCOSA; GLYCOSAMINOGLYCANS; LIPID PEROXIDATION; MALE; RATS; RATS, WISTAR; RESTRAINT, PHYSICAL; STOMACH; STOMACH ULCER; STRESS; SUPEROXIDE DISMUTASE;

EID: 34250809547     PISSN: 18806546     EISSN: None     Source Type: Journal    
DOI: 10.2170/physiolsci.RP004707     Document Type: Article

References (41)

1. Gidron Y, Russ K, Tissarchondou H, Warner J. The relation between psychological factors and DNA-damage: A critical review. Biol Psychol. 2006;72:291-304.
2. Federici M, Lauro R. Review article: diabetes and atherosclerosis-running on a common road. Aliment Pharcol Ther. 2005; 22 (Suppl 2): 11-5.
3. Kioukia-Fougia N, Antoniou K, Bekrs S, Liapi C, Christofidis I, Papadopoulou-Dafoti Z.The effects of stress exposure on hypothalamic-pituitary- adrenal axis, thymus, thyroid hormones and glucose levels. Prog Neuropharmacol Biol Psychiat. 2002;26:823-30.
4. Iwa M, Nakade Y, Pappas TN, Takahshi T. Electroacupuncture improves restraint stress-induced delay of gastric emptying via central glutaminergic pathways in conscious rats. Neurosci Lett. 2006;399:6-10.
5. Nakade Y, Tsuchida D, Fukuda H, Iwa M, Pappas TN, Takahashi T. Restraint stress augments postprandial gastric contractions but impairs antropyloric coordination in conscious rats. Am J Physiol Regul Integr Comp Physiol. 2006;290:R616-24.
6. Dhuley JN. Investigation on the gastroprotective and antidiarrhoeal properties of Aegle marmelos unripe fruit extract. Hindustan Antibiot Bull. 2003, 2004; 45-46: 41-6.
7. Rai D, Bhatia G, Sen T, Palit G. Anti-stress effects of ginkgo biloba and Panax ginseng: a comparative study. J Pharmacol Sci. 2003;93:458-64.
8. Izgut-Uysal VN, Agac A, Derin N. Effect of carnitine on stress-induced lipid peroxidation in rat gastric mucosa. J. Gastroenterol. 2001;36:231-6.
9. Liu J, Wang X, Shigenaga MK, Yeo HC, Mori A, Ames BN. Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats. FASEB J. 1996; 10 (13): 1532-8.
10. Bagchi D, Carryl OR, Tran MX, Bagchi M, Garg A, Milnes MM, et al. Acute and chronic stress-induced oxidative gastrointestinal mucosal injury in rats and proection by bismuthsalycylate. Mol Cell Biochem. 1999;196:109-16.
11. Das D, Banerjee RK. Effect of stress on the antioxidant enzymes and gastric ulceration. Mol Cell Biochem. 1993; 25; 125 (2): 115-25.
12. Fontella FU, Siqueira IR, Vasconcellos AP, Tabajara AS, Netto CA, Dalmaz C. Repeated restraint stress induces oxidative damage in rat hippocampus. Neurochem Res. 2005; 30 (1): 105-11.
13. Öner G, Senturk UK, Izgut-Uysal N. The role of cadmium in the peroxidative response of kidney to stress. Biol Trace Elem Res. 1995; 48 (1): 111-7.
14. Brzozowski T, Konturek SJ, Phtko-Polonczyk J, Warzecha Z. Gastric adaptation to stress: role of sensory nerves. Scand J Gastroenterol. 1995;30:6-16.
15. Bertelli A, Conte A, Ronca G. L-propionyl carnitine protects erythrocytes and low density lipoproteins against peroxidation. Drugs Exp. Clin. Res. 1994;20:191-7.
16. Di Giacomo C, Latteri F, Fichera C, Sorrenti V, Campisi A, Castorina C, et al. Effect of acetyl-L-carnitine on lipid peroxidation and xanthine oxidase activity in rat skeletal muscle. Neurochem. Res. 1993;18:1157-62.
17. Ferrari R, Ciampalini G, Agnoletti G, Cargnoni A, Ceconi C, Visioli O. Effect of L-carnitine derivatives on heart mitochondrial damage induced by lipid peroxidation. Pharmacol. Res. Commun. 1988;20:125-32.
18. Koudelova J, Mourek J, Drahota Z, Rauchova H. Protective effect of carnitine on lipoperoxide formation in rat brain. Physiol Res. 1994;43:387-9.
19. Izgut-Uysal VN, Agac A, Derin N, Karadogan I. Effects of L-carnitine on neutrophil functions in aged rats. Mech Ageing Dev. 2003;124:341-7.
20. Fritz IB, Arrigoni-Martelli E. Sites of action of carnitine and its derivatives on the cardiovascular system: interactions with membranes. TIPS 1993;14:355-60.
21. Corne S, Morrissey SM, Woods RJ. A method for quantitative estimation of gastric barrier mucus. J. Physiol (Lond). 1974;242:1169-79.
22. Cockrell CS, Ellis EF. Simple single-step high performance liquid chromatographic method for the separation of cyclooxygenase and lipooxygenase enzyme metabolites of arachidonic acid. J Chromatogr. 1984;308:316-21.
23. Stocks J, Dormandy TL. The autooxidation of human red cell lipids induced by hydrogen peroxide. Br. J. Haematol. 1971;20:95-111.
24. Stocks J, Offerman EL, Modell CB, Dormandy TL. The susceptibility to autooxidation of human red cell lipids in health and disease. Br J Haematol. 1972;23:713-24.
25. Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972; 25; 247: 3170-5.
26. Aebi HE. Catalase. In: Bergmeyer HV, Bergmeyer J, Grabl M, editors. Methods of enzymatic analysis. Third ed. Vol: 3. Germany: VCH Verlagsgesellschuft mbH, 1983; p. 273-88.
27. Dokmeci D, Akpolat M, Aydogdu N, Doganay L, Turan FN. L-carnitine inhibits ethanol-induced gastric mucosal injury in rats. Pharmacol Rep. 2005;57:481-8.
28. Liu J, Wang X, Shigenaga MK, Yeo HC, Mori A, Ames BN. Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats. FASEB J. 1996;10:1532-8.
29. Liu J, Mori A. Stress, aging and brain oxidative damage. Neurochem. Res. 1999;24:1479-97.
30. Manjari V, Das UN. Effect of polyunsaturated fatty acids on dexamathasone-induced gastric mucosal damage. Prostag Leukotr Ess. 2000;62:85-96.
31. Tandon R, Khanna HD, Dorababu M, Goel RK. Oxidative stress and antioxidants status in peptic ulcer and gastric carcinoma. Indian J Physiol Pharmacol. 2004;48:115-8.
32. Oh TY, Yeo M, Han SU, Cho YK, Kim YB, Chung MH, et al. Synergism of Helicobacter pylori infection and stress on the augmentation of gastric mucosal damage and its prevention with alpha-tocopherol. Free Radic Biol Med. 2005;1:38: 1447-57.
33. 2 in hippocampal and cerebral cortex slices. Braz J Med Biol Res. 2001, 34: 111-6.
34. Kwiecien S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol. 2002; 53, 1: 39-50.
35. Kwiecien S, Brzozowski T, Konturek PC, Konturek SJ. The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosa lesions. J Physiol Pharmacol. 2002; 53, 4: 761-73.
36. Kwiecien S, Brzozowski T, Konturek PC, Pawlik MW, Pawlik WW, Kwiecien N. The role of reactive oxygen species and capsaicin. Sensitive sensory nerves in the pathomechanisms of gastric ulcers induced by stress. J Physiol Pharmacol. 2003;54:423-7.
37. Ronca G, Ronca F, Yu G, Zucchi R, Bertelli A. Protection of isolated perfused working rat heart from oxidative stress by exogenous L-propionyl carnitine. Drugs Exp Clin Res. 1992; XVIII: 475-80.
38. 2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation. Prostaglandins Other Lipid Mediat. 1999;57:291-303.
39. 2 in rat gastric mucosa. Gastroenterol Jpn. 1981;16:236-41.
40. Takezono Y, Joh T, Oshima T, Suzuki H, Seno K, Yokoyama Y, et al. Role of prostaglandins in maintaining gastric mucus-cell permeability against acid exposure. J Lab Clin Med. 2004;143:52-8.
41. Rao ChV, Ojha SK, Radhakrishnan K, Gavindarajan R, Rastogi S, Mehrotra S, et al. Antiulcer activity of Utleria salicifolia rhizome extract. J Ethnopharmacol. 2004;91:243-9.