Antidiabetic and antioxidant effects of Vitis vinifera L. leaves in streptozotocin-diabetic rats

Turkish Journal of Pharmaceutical Sciences

Volumn 3, Issue 1, 2006, Pages 7-17

  Şendoǧdu, Nilüfer ^a   Aslan, Mustafa ^a   Deliorman Orhan, Didem ^a   Ergun, Fatma ^a   Yeşilada, Erdem ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

Antidiabetic; Antioxidant; GSH; Hypoglycaemia; Lipid peroxidation; MDA; Vitis vinifera

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; ALCOHOL; FLAVANOID; GLUCOSE; GLUCOSE OXIDASE; GLUTATHIONE; STREPTOZOCIN; TANNIN DERIVATIVE; VITIS VINIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG EFFECT; GLUCOSE BLOOD LEVEL; GRAPE; HEART; HYPERGLYCEMIA; KIDNEY PARENCHYMA; LIVER; MALE; NONHUMAN; PLANT LEAF; RAT; SUSTAINED RELEASE PREPARATION;

EID: 34250808242     PISSN: 1304530X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Davis, P.H. Flora of Turkey and East Eagean Islands, Edinburgh University Press, Edinburgh, Vol:2, pp. 521-522, 1997.
2. Bombardelli, E., Morazzonni, P., "Vitis vinifera L." Fitoterapia 66, 291-317, 1995.
3. Hebash, K.A.H., Fadel, H.M. and Soliman, M.M.A., "Volatile components of grape leaves" JIAS 4(1), 26-28, 1991.
4. Felicio, J.D., Santos, R.S. and Goncalez, E., "Chemical constituents from Vitis vinifera (Vitaceae)" Arq. Inst. Biol. 68(1), 47-50, 2001.
5. Baytop, T. Bitkiler İle Tedavi (Geçmişte ve Bugün), 2. Baski, Nobel Tip Kitabevleri, İstanbul, pp. 357-358, 1999.
6. Zimmet, P.Z., McCarty, D.J. and Courten, M.P., "The global epidemiology of non-insulin dependent diabetes mellitus and the metabolic syndrome" J. Diabetes Complicat. 11, 60-68, 1997.
7. Atalay, M. and Laaksonen, D.E., "Diabetes, oxidative stres and physical exercise" J. Sports Sci. & Med. 1, 1-14, 2002.
8. West, I.C., "Radicals and oxidative stress in diabetes" Diabet Med. 17, 171-180, 2000.
9. Gumieniczek, A., Hopkala, H., Wojtowicz, Z. and Nikolajuk, J., "Changes in antioxidant status of heart muscle tissue in experimental diabetes in rabbits" Acta Biochem. Pol. 49(2), 529-535, 2002.
10. Aydin, A., Orhan, H., Sayal, A., Özata, M., Şahin, G. and Işimer, A., "Oxidative stres and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control" Clin. Biochem. 34, 65-70, 2001.
11. Landcake, P., Cornford, C.A., and Pryce, R.J., "Identification of Pterosilbene as a phytoalexin from Vitis vinifera leaves." Phytochemistry 18, 1025-1027, 1979.
12. Aslan, M., Sezik, E., Yeşilada, E., " Antihyperglycaemic effect of Cannabis sativa L. fruits" J. Fac. Pharm. Gazi University-GUEDE 17, 89-93, 2000.
13. Aslan, M., Sezik, E., Yeşilada, E., "Effect of Hibiscus esculentus L. seeds on blood glucose levels in normoglycaemic, glucose-hyperglycaemic and streptozotocin induced diabetic rats" J. Fac. Pharm. Gazi University-GUEDE 20, 1-7 , 2003.
14. Jamall, I.S., Smith, J.C.,"Effects of cadmium on glutathione peroxidase, superoxide dismutase, and lipid peroxidation in the rat heart: a possible mechanism of cadmium cardiotoxicity" Toxicol. Appl. Pharmacol. 80, 33-42, 1985.
15. Ohkawa, H., Ohishi, N., Yagi, K., "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction" Anal. Biochem. 95, 351-358, 1979.
16. Sedlak, J., Lindsay, R.H., "Estimation of total protein-band and nonprotein sulfhydryl group in tissue with Ellman's reagent" Anal. Biochem. 25, 192-205, 1968.
17. Şendoǧdu, N., "Vitis vinifera L. yapraklarinin şeker hastaliǧi üzerine etkilerinin araştirilmasi", Yüksek Lisans Tezi, Gazi Üniversitesi Saǧlik Bilimleri Enstitüsü, Farmakognozi Anabilim Dali, Ankara (2004).
18. Elstner, E.F., Kleber, E., in "Flavonoids in Biology and medicine III: Current issues in flavanoid research", N.P. Das (Ed.), National University of Singapore 227-235, 1990.
19. Perez, R.M., Zavala, G.M.A., Perez, S.G., Perez, C.G., "Antidiabetic effect of compounds isolated from plants", Phytomed. 5, 55-75, 1998.