Lack of clinical usefulness of interleukin-6 in long-term follow-up of acutely decompensated heart failure

Singapore Medical Journal

Volumn 48, Issue 6, 2007, Pages 532-536

  Ruiz Ruiz, Francisco J ^a   Ruiz Laiglesia, F J ^b   Lasierra Diaz, P ^b   Samperiz Legarre, P ^b   Morales Rull, J L ^a   Sanchez Marteles M ^a   Amores, M ^b   Perez Calvo, J I ^b  

^a HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^b UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

Cytokines; Decompensated heart failure; Heart failure prognosis; Interleukin 6

Indexed keywords

INTERLEUKIN 6; BIOLOGICAL MARKER;

ACUTE HEART FAILURE; AGED; ANALYTIC METHOD; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; REGRESSION ANALYSIS; SURVIVAL; SYSTOLIC DYSFUNCTION; BLOOD; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; KAPLAN MEIER METHOD; MORTALITY; PREDICTION AND FORECASTING; RISK; SPAIN;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE, CONGESTIVE; HUMANS; INTERLEUKIN-6; KAPLAN-MEIERS ESTIMATE; MALE; ODDS RATIO; PATIENT READMISSION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SPAIN;

EID: 34250798615     PISSN: 00375675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Stewart S, MacIntyre K, Capewell S, McMurray JJ. Heart failure and the aging population: an increasing burden in the 21st century? Heart 2003; 89:49-53.
2. Mann DL. Mechanisms and models in heart failure: A combinatorial approach. Circulation 1999; 100:999-1008.
3. Braunwald E, Bristow MR. Congestive heart failure: fifty years of progress. Circulation 2000; 102(20 Suppl 4):IV14-23.
4. Mann DL, Young JB. Basic mechanisms in congestive heart failure. Recognizing the role of proinflammatory cytokines. Chest 1994; 105:897-904.
5. Finkel MS, Oddis CV, Jacob TD, et al. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992; 257:387-9.
6. Finkel MS, Hoffman RA, Shen L, et al. Interleukin-6 (IL-6) as a mediator of stunned myocardium. Am J Cardiol 1993; 71:1231-2.
7. Orus J, Roig E, Perez-Villa F, et al. Prognostic value of serum cytokines in patients with congestive heart failure. J Heart Lung Transplant 2000; 19:419-25.
8. Deswal A, Petersen NJ, Feldman AM, et al. Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation 2001; 103:2055-9.
9. Raymond RJ, Dehmer GJ, Theoharides TC, Deliargyris EN. Elevated interleukin-6 levels in patients with asymptomatic left ventricular systolic dysfunction. Am Heart J 2001; 141:435-8.
10. Vasan RS, Levy D. Defining diastolic heart failure: a call for standardized diagnostic criteria. Circulation 2000; 101:2118-21.
11. Comment in: Circulation 2000; 101:2020-1,
12. Circulation 2001; 103: E82.
13. Katz JN, Drazner MH. Assessing prognosis in heart failure: is hepatocyte growth factor the next B-type natriuretic peptide? Am Heart J. 2005; 150:1-3.
14. Comment on: Am Heart J. 2005;150:137-43.
15. Torre-Amione, Kapadia S, Benedict C, et al. Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 1996; 27:1201-6.
16. Vasan RS, Sullivan LM, Roubenoff R, et al. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham heart study. Circulation 2003; 107:1486-91.
17. Comment in: Circulation 2003 25;107:1460-2,
18. Circulation 2003;107:e9020-1.
19. Sato Y, Takatsu Y, Kataoka K, et al. Serial circulating concentrations of C-reactive protein, interleukin (IL)-4, and IL-6 in patients with acute left heart decompensation. Clin Cardiol 1999; 22:811-3.
20. Suzuki H, Sato R, Sato T, et al. Time-course of changes in levels of interleukin 6 in acutely decompensated heart failure. Int J Cardiol 2005; 100:415-20.
21. Comment in: Int J Cardiol 2006;112:112; author reply 113.
22. Harris TB, Ferrucci L, Tracy RP, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 1999; 106:506-12.
23. Bruunsgaard H. Effects of tumor necrosis factor-alpha and interleukin-6 in elderly populations. Eur Cytokine Netw 2002; 13:389-91.
24. Krabbe KS, Pedersen M, Bruunsgaard H. Inflammatory mediators in the elderly. Exp Gerontol. 2004; 39:687-99.
25. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340:448-54. Erratum in: N Engl J Med 1999; 340:1376.
26. Testa M, Yeh M, Lee P, et al. Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary disease or hypertension. J Am Coll Cardiol 1996; 28:964-71.
27. Alonso-Martinez JL, Llorente-Diez B, Echegaray-Agara M, et al. Creactive protein as a predictor of improvement and readmission in heart failure. Eur J Heart Fail 2002; 4:331-6.