The ADRB3 Trp64Arg variant and obesity in African-American breast cancer cases

International Journal of Obesity

Volumn 31, Issue 7, 2007, Pages 1110-1118

  McKean Cowdin, R ^a   Li, X ^a   Bernstein, L ^a   McTiernan, A ^b   Ballard Barbash, R ^c   Gauderman, W J ^a   Gilliland, F ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

African American; Cancer; Magnetic resonance imaging; Visceral fat

Indexed keywords

ADULT; AFRICAN AMERICAN; ALLELE; ARTICLE; BODY MASS; BODY WEIGHT; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER MORTALITY; CANCER RECURRENCE; CANCER RISK; CODON; COHORT ANALYSIS; CONFIDENCE INTERVAL; FEMALE; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MENOPAUSE; MISSENSE MUTATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; OBSERVATIONAL STUDY; PHYSICAL ACTIVITY; PREMENOPAUSE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SUBCUTANEOUS FAT; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WEIGHT GAIN;

ADULT; AFRICAN AMERICANS; BODY MASS INDEX; BREAST NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTRA-ABDOMINAL FAT; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; MUTATION, MISSENSE; OBESITY; PREDICTIVE VALUE OF TESTS; RECEPTORS, ADRENERGIC, BETA-3; SUBCUTANEOUS FAT; WAIST-HIP RATIO;

EID: 34250793330     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803554     Document Type: Article

References (56)

1. American Cancer Society. Detailed Guide: Breast Cancer. What are the Key Statistics for Breast Cancer?. Atlanta, GA, 2005. www.cancer.org.
2. Chlebowski RT, Aiello E, McTiernan A. Weight loss in breast cancer patient management. J Clin Oncol 2002; 20: 1128-1143.
3. Demark-Wahnefried W, Rimer BK, Winer EP. Weight gain in women diagnosed with breast cancer. J Am Diet Assoc 1997; 97: 519-526, 529; quiz 527-528.
4. Daling JR, Malone KE, Doody DR, Johnson LG, Gralow JR, Porter PL. Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma. Cancer 2001; 92: 720-729.
5. Newman SC, Lees AW, Jenkins HJ. The effect of body mass index and oestrogen receptor level on survival of breast cancer patients. Int J Epidemiol 1997; 26: 484-490.
6. Goodwin P, Esplen MJ, Butler K, Winocur J, Pritchard K, Brazel S et al. Multidisciplinary weight management in locoregional breast cancer: results of a phase II study. Breast Cancer Res Treat 1998; 48: 53-64.
7. Weiderpass E, Braaten T, Magnusson C, Kumle M, Vainio H, Lund E et al. A prospective study of body size in different periods of life and risk of premenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 2004; 13: 1121-1127.
8. Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C et al. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 2003; 95: 1218-1226.
9. Bouchard C, Perusse L. Genetics of obesity. Annu Rev Nutr 1993; 13: 337-354.
10. Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 1997; 27: 325-351.
11. Emorine L, Blin N, Strosberg AD. The human beta 3-adrenoceptor: the search for a physiological function. Trends Pharmacol Sci 1994; 15: 3-7.
12. Oizumi T, Daimon M, Saitoh T, Kameda W, Yamaguchi H, Ohnuma H et al. Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample. Diabetes Care 2001; 24: 1579-1583.
13. Widen E, Lehto M, Kanninen T, Walston J, Shuldiner AR, Groop LC. Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. N Engl J Med 1995; 333: 348-351.
14. Mitchell BD, Blangero J, Comuzzie AG, Almasy LA, Shuldiner AR, Silver K et al. A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans. J Clin Invest 1998; 101: 584-587.
15. Clement K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J et al. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 1995; 333: 352-354.
16. McTiernan A, Rajan KB, Tworoger SS, Irwin M, Bernstein L, Baumgartner R et al. Adiposity and sex hormones in post-menopausal breast cancer survivors. J Clin Oncol 2003; 21: 1961-1966.
17. Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD et al. Physical activity levels before and after a diagnosis of breast carcinoma: the health, eating, activity, and lifestyle (HEAL) study. Cancer 2003; 97: 1746-1757.
18. Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K et al. Physical activity levels among breast cancer survivors. Med Sci Sports Exerc 2004; 36: 1484-1491.
19. McTiernan A, Rajan KB, Tworoger SS, Irwin M, Bernstein L, Baumgartner R et al. Adiposity and sex hormones in post-menopausal breast cancer survivors. J Clin Oncol 2003; 21: 1961-1966.
20. Kriska A. Modifiable activity questionnaire. Med Sci Sports Exerc 1997; 29: S73-S78.
21. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000; 32 (Suppl 9): S498-S504.
22. Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 2002; 288: 1728-1732.
23. Livak KJ. Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal 1999; 14: 143-149.
24. Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med 1995; 333: 343-347.
25. Kadowaki H, Yasuda K, Iwamoto K, Otabe S, Shimokawa K, Silver K et al. A mutation in the beta 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochem Biophys Res Commun 1995; 215: 555-560.
26. Nagase T, Aoki A, Yamamoto M, Yasuda H, Kado S, Nishikawa M et al. Lack of association between the Trp64 Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: a longitudinal analysis. J Clin Endocrinol Metab 1997; 82: 1284-1287.
27. Lowe Jr WL, Rotimi CN, Luke A, Guo X, Zhu X, Comuzzie AG et al. The beta 3-adrenergic receptor gene and obesity in a population sample of African Americans. Int J Obes Relat Metab Disord 2001; 25: 54-60.
28. Terra SG, McGorray SP, Wu R, McNamara DM, Cavallari LH, Walker JR et al. Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. Int J Obes Relat Metab Disord 2005; 29: 746-754.
29. McFarlane-Anderson N, Bennett F, Wilks R, Howell S, Newsome C, Cruickshank K et al. The Trp64Arg mutation of the beta3-adrenergic receptor is associated with hyperglycemia and current body mass index in Jamaican women. Metabolism 1998; 47: 617-621.
30. Emorine LJ, Marullo S, Briend-Sutren MM, Patey G, Tate K, Delavier-Klutchko C et al. Molecular characterization of the human beta 3-adrenergic receptor. Science 1989; 245: 1118-1121.
31. Arner P, Hoffstedt J. Adrenoceptor genes in human obesity. J Intern Med 1999; 245: 667-672.
32. Candelore MR, Deng L, Tota LM, Kelly LJ, Cascieri MA, Strader CD. Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant. Endocrinology 1996; 137: 2638-2641.
33. Pietri-Rouxel F, St John Manning B, Gros J, Strosberg AD. The biochemical effect of the naturally occurring Trp64→Arg mutation on human beta3-adrenoceptor activity. Eur J Biochem 1997; 247: 1174-1179.
34. Hoffstedt J, Poirier O, Thorne A, Lonnqvist F, Herrmann SM, Cambien F et al. Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function. Diabetes 1999; 48: 203-205.
35. Heasman KZ, Sutherland HJ, Campbell JA, Elhakim T, Boyd NF. Weight gain during adjuvant chemotherapy for breast cancer. Breast Cancer Res Treat 1985; 5: 195-200.
36. Gagnon J, Mauriege P, Roy S, Sjostrom D, Chagnon YC, Dionne FT et al. The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Quebec Family Study and Swedish Obese Subjects cohorts. J Clin Invest 1996; 98: 2086-2093.
37. Lonnqvist F, Thome A, Nilsell K, Hoffstedt J, Arner P. A pathogenic role of visceral fat beta 3-adrenoceptors in obesity. J Clin Invest 1995; 95: 1109-1116.
38. Hoffstedt J, Shimizu M, Sjostedt S, Lonnqvist F. Determination of beta 3-adrenoceptor mediated lipolysis in human fat cells. Obes Res 1995; 3: 447-457.
39. Katzmarzyk PT, Perusse L, Bouchard C. Genetics of abdominal visceral fat levels. Am J Human Biol 1999; 11: 225-235.
40. Sakane N, Yoshida T, Umekawa T, Kondo M, Sakai Y, Takahashi T. Beta 3-adrenergic-receptor polymorphism: a genetic marker for visceral fat obesity and the insulin resistance syndrome. Diabetologia 1997; 40: 200-204.
41. Pasquali R, Casimirri F, Labate AM, Tortelli O, Pascal G, Anconetani B et al. Body weight, fat distribution and the menopausal status in women. The VMH Collaborative Group. Int J Obes Relat Metab Disord 1994; 18: 614-621.
42. Ley CJ, Lees B, Stevenson JC. Sex- and menopause-associated changes in body-fat distribution. Am J Clin Nutr 1992; 55: 950-954.
43. Aloia JF, McGowan DM, Vaswani AN, Ross P, Cohn SH. Relationship of menopause to skeletal and muscle mass. Am J Clin Nutr 1991; 53: 1378-1383.
44. Huang XE, Hamajima N, Saito T, Matsuo K, Mizutani M, Iwata H et al. Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer. Breast Cancer Res 2001; 3: 264-269.
45. Demark-Wahnefried W, Peterson BL, Winer EP, Marks L, Aziz N, Marcom PK et al. Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol 2001; 19: 2381-2389.
46. Aslani A, Smith RC, Allen BJ, Pavlakis N, Levi JA. Changes in body composition during breast cancer chemotherapy with the CMF-regimen. Breast Cancer Res Treat 1999; 57: 285-290.
47. Demark-Wahnefried W, Winer EP, Rimer BK. Why women gain weight with adjuvant chemotherapy for breast cancer. J Clin Oncol 1993; 11: 1418-1429.
48. Slentz CA, Aiken LB, Houmard JA, Bales CW, Johnson JL, Tanner CJ et al. Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount. J Appl Physiol 2005; 99: 1613-1618.
49. Santeusanio F, Di Loreto C, Lucidi P, Murdolo G, De Cicco A, Parlanti N et al. Diabetes and exercise. J Endocrinol Invest 2003; 26: 937-940.
50. Irwin ML, Yasui Y, Ulrich CM, Bowen D, Rudolph RE, Schwartz RS et al. Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial. JAMA 2003; 289: 323-330.
51. Warren M, Schreiner PJ, Terry JG. The relation between visceral fat measurement and torso level - is one level better than another? The Atherosclerosis Risk in Communities Study 1990-1992. Am J Epidemiol 2006; 163: 352-358.
52. Bernstein L, Henderson BE, Hanisch R, Sullivan-Halley J, Ross RK. Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst 1994; 86: 1403-1408.
53. Gilliland FD, Li YF, Baumgartner K, Crumley D, Samet JM. Physical activity and breast cancer risk in hispanic and non-hispanic white women. Am J Epidemiol 2001; 154: 442-450.
54. International Agency for Research on Cancer. Weight Control and Physical Activity. IARC Handbooks for Cancer Prevention vol. 6 IARC Press: Lyon, France, 2002.
55. Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA. Physical activity and survival after breast cancer diagnosis. JAMA 2005; 293: 2479-2486.
56. Marti A, Corbalan MS, Martinez-Gonzalez MA, Martinez JA. TRP64ARG polymorphism of the beta 3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Diabetes Obes Metab 2002; 4: 428-430.