Methylation status in females with Rett syndrome

Journal of Child Neurology

Volumn 22, Issue 5, 2007, Pages 635-638

  Freilinger, Michael ^a   Kalisch, David ^a   Müehl, Adolf ^a   Haas, Oskar ^b   Moritz, Anne ^b   Bodamer, Olaf ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

Homocysteine; Methionine; Methylation; Rett syndrome

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; CREATINE; CREATININE; CYANOCOBALAMIN; FOLIC ACID; GENOMIC DNA; GUANIDINOACETIC ACID; HOMOCYSTEINE; LAMOTRIGINE; METHIONINE; METHYL CPG BINDING PROTEIN 2; SULTIAME; TOPIRAMATE; VALPROIC ACID;

ADOLESCENT; ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CHILD; CLINICAL ARTICLE; CREATININE URINE LEVEL; DNA METHYLATION; FEMALE; FOLIC ACID BLOOD LEVEL; GENE DELETION; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; RETT SYNDROME; VITAMIN BLOOD LEVEL;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CREATINE; FEMALE; FOLIC ACID; HUMANS; METHIONINE; METHYL-CPG-BINDING PROTEIN 2; METHYLATION; RETT SYNDROME;

EID: 34250782723     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/0883073807302616     Document Type: Article

References (13)

1. Rett A. On a unusual brain atrophy syndrome in hyperammonemia in childhood. Wien Med Wochenschr. 1966; 116: 723-726.
2. Hagberg B., Hanefeld F., Percy A., Skjeldal O. An update on clinically applicable diagnostic criteria in Rett syndrome: Comments to Rett syndrome. Eur J Paediatr Neurol. 2002; 6: 293-297.
3. Amir RE, Van den Veyver IB, Wan M., Tran CQ, Francke U., Zoghbi HY Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet. 1999; 23: 185-188.
4. Percy AK, Lane JB Rett syndrome: Clinical and molecular update. Curr Opin Pediatr. 2004; 16: 670-677.
5. Finkelstein JD The metabolism of homocysteine: Pathways and regulation. Eur J Pediatr. 1998; 157 (suppl 2): S40-S44.
6. Van den Veyver IB Genetic effects of methylation diets. Annu Rev Nutr. 2002; 22: 255-282.
7. Kriaucionis S., Bird A. DNA methylation and Rett syndrome. Hum Mol Genet. 2003; 15: 221-227.
8. Mattson MP, Shea TB Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 2003; 26: 137-146.
9. Ramaekers VT, Hansen SI, Holm J., et al. Reduced folate transport to the CNS in female Rett patients. Neurology. 2003; 61: 506-515.
10. Ormazabal A., Artuch R., Vilaseca MA, Aracil A., Pineda M. Cerebrospinal fluid concentrations of folate, biogenic amines and pterins in Rett syndrome: Treatment with folinic acid. Neuropediatrics. 2005; 36: 380-385.
11. James SJ, Cutler P., Melnyk S., et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004; 80: 1611-1717.
12. Wolff GL, Kodell RL, Moore SR, Cooney CA Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J. 1998; 12: 949-957.
13. Percy AK, Lane JB Rett syndrome: Model of neurodevelopmental disorders. J Child Neurol. 2005; 20: 718-722.