Separation and quantification of two diastereomers of a Drug Candidate in rat plasma by ultra-high pressure liquid chromatography/mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 854, Issue 1-2, 2007, Pages 26-34

  Wang, Haiping ^a   Edom, Richard W ^a   Kumar, Sanjeev ^a   Vincent, Stella ^a   Shen, Zhongzhou ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Diastereomers; Quantitation; UHPLC MS MS

Indexed keywords

DRUG PRODUCTS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

DIASTEREOMERS; EPIMERIZATION; SPRAGUE-DAWLEY RATS;

BIOMEDICAL ENGINEERING;

DRUG;

ACCURACY; ARTICLE; BLOOD LEVEL; CHIRALITY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG DETERMINATION; EPIMER; EPIMERIZATION; EX VIVO STUDY; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PRODUCTIVITY; QUANTITATIVE ANALYSIS; RAT; REDUCTION; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 34250776995     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.03.040     Document Type: Article

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