Acyclovir delivery matrices based on poly (ethylene glycol)/chitosan semi-interpenetrating networks

Journal of Pharmaceutical Sciences

Volumn 96, Issue 6, 2007, Pages 1653-1657

  Diez Sales, O ^a   Dolz, M ^a   Hernandez, M J ^a   Casanovas, A ^a   Herraez, M ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Acyclovir release; Chitosan; Cross linking; Oscillatory rheometry; Viscoelasticity

Indexed keywords

ACICLOVIR; CHITOSAN; GLYOXAL; MACROGOL;

ARTICLE; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG RELEASE; HYDROGEL; HYDROPHILICITY; NONHUMAN; VISCOELASTICITY;

EID: 34250756017     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20825     Document Type: Article

References (16)

1. Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R. 2004. Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur J Pharm Biopharm 57:19-34.
2. Felt O, Furrer P, Mayer JM, Plazonnet B, Buri P, Gurny R. 1999. Topical use of chitosan in ophtalmology: Tolerance assessment and evaluation of precorneal retention. Int J Pharm 180:185-193.
3. He P, Davis SS, Illum L. 1998. In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int J Pharm 166:75-88.
4. Li J, Xu Z. 2002. Physical characterization of chitosan-based hydrogel delivery system. J Pharm Sci 91:1669-1677.
5. Ueno H, Mori T, Fujinaga T. 2001. Topical formulations and wound healing applications of chitosan. Adv Drug Deliv Rev 52:105-115.
6. Liu XF, Guan YL, Yang DZ, Li Z, Yao KD. 2001. Antibacterial action of chitosan and carboxymethylated chitosan. J Appl Polym Sci 79:1324-1335.
7. Patel VR, Amiji MM, 1996. Preparation and characterization of freeze-dried chitosan-poly(ethylene oxide) hydrogels for site-specific antibiotic delivery in the stomach. Pharm Res 13:588-593.
8. Khalid MN, Ho L, Agnely JL, Grossiord JL, Couarraze G. 1999. Swelling properties and mechanical characterization of a semi-interpenetrating chitosan/polyethylene oxide network. Comparison with chitosan reference gel. STP Pharm Sci 9:359-364.
9. Lee SJ, Kim SS, Lee YM. 2000. Interpenetrating polymer network hydrogels based on poly(ethylene glycol) macromer and chitosan. Carbohydr Polym 41:197-205.
10. Capitani D, De angelis AA, Crescenzi V, Masci G, Segre AL. 2001. N.M.R. study, of a novel chitosan-based hydrogel. Carbohydr Polym 45:245-252.
11. Higuchi T. 1962. Analysis of data on the medicament release from ointments. J Pharm Sci 51:802-804.
12. Lapasin R, Pricl S. 1995. Rheology of industrial polysaccharides: Theory and applications. London: Chapman and Hall.
13. Brack HP, Timizi WM, Risen A. 1997. A spectroscopic and viscosimetric study of the metal ion-induced gelation of the biopolymer chitosan. Polymer 38:2351-2362.
14. Clark AH, Ross-Murphy SB. 1987. Structural and mechanical properties of biopolymer gels. Adv Polymer Sci 83:57-192.
15. Diez-Sales O, Garrigues TM, Herraez JV, Belda R, Martín-Villodre A, Herraez M. 2005. In vitro percutaneous penetration of acyclovir from solvent systems and Carbopol 971-P hydrogels: Influence of propylene glycol. J Pharm Sci 94:1039-1047.
16. Chang SH, Parrot SL. 1991. Relationship of dissolution rate in anionic polymeric solutions to viscosity. Drug Dev Ind Pharm 17:201-213.