Chronic treatment with carvedilol improves Ca2+-dependent ATP consumption in triton X-skinned fiber preparations of human myocardium

Journal of Pharmacology and Experimental Therapeutics

Volumn 322, Issue 1, 2007, Pages 222-227

  Brixius, K ^a,b   Lu, R ^b,d   Boelck, B ^b   Grafweg, S ^b   Hoyer, F ^b   Pott, C ^e   Mehlhorn, U ^b   Bloch, W ^a   Schwinger, Robert H G ^b,c  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c Hospital of Weiden   (Germany)

^d SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^e UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ION; CARVEDILOL; METOPROLOL; MYOSIN ADENOSINE TRIPHOSPHATASE; OCTOXINOL; TROPONIN I;

ADULT; ARTICLE; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; ENZYME ACTIVITY; EXPLANT; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE TENSION; HEART TRANSPLANTATION; HUMAN; HUMAN TISSUE; LONG TERM CARE; MALE; MUSCLE FIBRIL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SKINNED MUSCLE FIBER;

ADRENERGIC BETA-ANTAGONISTS; CALCIUM; CARBAZOLES; HEART; HEART FAILURE, CONGESTIVE; HUMANS; METOPROLOL; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOFIBRILS; MYOSINS; OCTOXYNOL; PHOSPHORYLATION; PROPANOLAMINES; TROPONIN I;

EID: 34250741434     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.116798     Document Type: Article

References (31)

1. Arumanayagam M, Chan S, Tong S, and Sanderson JE (2001) Antioxidant properties of carvedilol and metoprolol in heart failure: a double-blind randomized controlled trial. J Cardiovasc Pharmacol 37:48-54.
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. 2+-sensitivity of myofibrillar tension in heart failure and its functional implication. Basic Res Cardiol 97 (Suppl 1):I111-I117.
4. Brixius K and Schwinger RH (2000) Modulation of cross-bridge interaction by 2,3-butanedione monoxime in human ventricular myocardium. Naunyn Schmiedebergs Arch Pharmacol 361:440-444.
5. 2+ sensitivity. Eur J Pharmacol 422:175-180.
6. De Sousa E, Veksler V, Minajeva A, Kaasik A, Mateo P, Mayoux E, Hoerter J, Bigard X, Serrurier B, and Ventura-Clapier R (1999) Subcellular creatine kinase alterations. Implications in heart failure. Circ Res 85:68-76.
7. Domanski MJ, Krause-Steinrauf H, Massie BM, Deedwania P, Follmann D, Kovar D, Murray D, Oren R, Rosenberg Y, Young J, et al. (2003) A comparative analysis of the results from 4 trials of beta-blocker therapy for heart failure: BEST, CIBIS-II, MERIT-HF, and COPERNICUS. J Card Fail 9:354-363.
8. Fabiato A and Fabiato F (1979) Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol (Paris) 75:463-505.
9. Flesch M, Maack C, Cremers B, Baumer AT, Sudkamp M, and Bohm M (1999) Effect of beta-blockers on free radical-induced cardiac contractile dysfunction. Circulation 100:346-353.
10. Gilbert EM, Abraham WT, Olsen S, Hattler B, White M, Mealy P, Larrabee P, and Bristow MR (1996) Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart. Circulation 94:2817-2825.
11. Guth K and Wojciechowski R (1986) Perfusion cuvette for the simultaneous measurement of mechanical, optical and energetic parameters of skinned muscle fibres. Pflugers Arch 407:552-557.
12. 2+ and force regulation. Basic Res Cardiol 87 (Suppl 1):143-159.
13. Hearse DJ (1979) Oxygen deprivation and early myocardial contractile failure: a reassessment of the possible role of adenosine triphosphate. Am J Cardiol 44:1115-1121.
14. Hill AV (1910) A new mathematical treatment of changes of ionic concentration in muscle and nerve under the action of electric currents, with a theory as to their mode of excitation. J Physiol 40:190-224.
15. Jane-Lise S, Corda S, Chassagne C, and Rappaport L (2000) The extracellular matrix and the cytoskeleton in heart hypertrophy and failure. Heart Fail Rev 5:239-250.
16. 2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition. FASEB J 13:313-324.
17. Konhilas JP, Irving TC, and de Tombe PP (2002) Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of interfilament spacing. Circ Res 90:59-65.
18. Lowes BD, Gilbert EM, Abraham WT, Minobe WA, Larrabee P, Ferguson D, Wolfel EE, Lindenfeld J, Tsvetkova T, Robertson AD, et al. (2002) Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents. N Engl J Med 346:1357-1365.
19. Maack C, Cremers B, Flesch M, Hoper A, Sudkamp M, and Bohm M (2000) Different intrinsic activities of bucindolol, carvedilol and metoprolol in human failing myocardium. Br J Pharmacol 130:1131-1139.
20. Metra M, Giubbini R, Nodari S, Boldi E, Modena MG, and Dei Cas L (2000) Differential effects of beta-blockers in patients with heart failure: a prospective, randomized, double-blind comparison of the long-term effects of metoprolol versus carvedilol. Circulation 102:546-551.
21. Nakamura K, Kusano K, Nakamura Y, Kakishita M, Ohta K, Nagase S, Yamamoto M, Miyaji K, Saito H, Morita H, Emori T, Matsubara H, Toyokuni S, Ohe T (2002) Carvedilol decreases elevated oxidative stress in human failing myocardium Circulation 105:2867-2871.
22. Narolska NA, van Loon RB, Boontje NM, Zaremba R, Penas SE, Russell J, Spiegelenberg SR, Huybregts MA, Visser FC, de Jong JW, et al. (2005) Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue. Cardiovasc Res 65:221-229.
23. Omerovic E, Bollano E, Soussi B, and Waagstein F (2003) Selective beta1-blockade attenuates post-infarct remodelling without improvement in myocardial energy metabolism and function in rats with heart failure. Eur J Heart Fail 5:725-732.
24. Poole-Wilson PA, Swedberg K, Cleland JG, Di Lenarda A, Hanrath P, Komajda M, Lubsen J, Lutiger B, Metra M, Remme WJ, et al. (2003) Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 362:7-13.
25. Reiken S, Wehrens XH, Vest JA, Barbone A, Klotz S, Mancini D, Burkhoff D, and Marks AR (2003) Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation 107:2459-2466.
26. Sanderson JE, Chan SK, Yip G, Yeung LY, Chan KW, Raymond K, and Woo KS (1999) Beta-blockade in heart failure: a comparison of carvedilol with metoprolol. J Am Coll Cardiol 34:1522-1528.
27. Schwinger RH, Bohm M, Koch A, Schmidt U, Morano I, Eissner HJ, Uberfuhr P, Reichart B, and Erdmann E (1994) The failing human heart is unable to use the Frank-Starling mechanism. Circ Res 74:959-969.
28. Swank RT and Munkres KD (1971) Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate. Anal Biochem 39:462-477.
29. 2+-sensitivity of force is enhanced in failing human hearts. Cardiovasc Res 57:505-514.
30. 2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins. Cardiovasc Res 57:37-47.
31. Wolff MR, Buck SH, Stoker SW, Greaser ML, and Mentzer RM (1996) Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation. J Clin Invest 98:167-176.