Ascertainment through family history of disease often decreases the power of family-based association studies

Behavior Genetics

Volumn 37, Issue 4, 2007, Pages 631-636

  Ferreira, Manuel A R ^a   Sham, Pak ^b,c   Daly, Mark J ^a,d   Purcell, Shaun ^a,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Association; Complex disease; Family history; Power; Study design; TDT

Indexed keywords

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FAMILY STUDY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HUMAN; MULTIFACTORIAL INHERITANCE; PARENT; PROGENY; RELATIVE; SAMPLE SIZE; SIBLING;

ADULT; CHILD; DISEASE; FEMALE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MEDICAL HISTORY TAKING; MODELS, GENETIC; NUCLEAR FAMILY; PEDIGREE; PREVALENCE;

EID: 34250732224     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10519-007-9149-0     Document Type: Article

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