Development and validation of a stability-indicating reversed-phase high performance liquid chromatography method for assay of betamethylepoxide and estimation of its related compounds

Journal of Chromatography A

Volumn 1157, Issue 1-2, 2007, Pages 207-216

  Xiao, Kang Ping ^a   Chien, Dwight ^a   Markovich, Robert ^a   Rustum, Abu M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Betamethylepoxide; Method development; Reversed phase HPLC; Stability indicating; Steroid intermediate; Validation

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS (API); BETAMETHYLEPOXIDE; EPIMERS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RPHPLC); STEROID;

ACETONITRILE; BIOASSAY; DISTILLATION COLUMNS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHANOL; WATER ANALYSIS;

DRUG PRODUCTS;

ACETONITRILE; ALPHAMETHYLEPOXIDE; BETAMETHYLEPOXIDE; CARBON; EPOXIDE; METHANOL; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; ASSAY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DEGRADATION KINETICS; DRUG IMPURITY; DRUG QUALITY; DRUG STABILITY; EPIMER; METHODOLOGY; PRIORITY JOURNAL; QUALITY CONTROL; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SYNTHESIS; VALIDATION PROCESS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPOXY COMPOUNDS; POLYCYCLIC COMPOUNDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

APIS;

EID: 34250694230     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.05.008     Document Type: Article

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