No evidence for a clear link between active intestinal inflammation and autism based on analyses of faecal calprotectin and rectal nitric oxide

Acta Paediatrica, International Journal of Paediatrics

Volumn 96, Issue 7, 2007, Pages 1076-1079

  Fernell, Elisabeth ^a   Fagerberg, Ulrika L ^a   Hellström, Per M ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Autism; Calprotectin; Intestinal inflammation; Nitric oxide

Indexed keywords

BIOLOGICAL MARKER; CALPROTECTIN; NITRIC OXIDE;

ADOLESCENT; ARTICLE; AUTISM; BACTERIAL INFECTION; CHILD; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE; CONSTIPATION; CONTROLLED STUDY; DISEASE MARKER; ENTERITIS; EVIDENCE BASED MEDICINE; FECES ANALYSIS; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RECTUM; UPREGULATION;

ADOLESCENT; AUTISTIC DISORDER; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; FECES; FEMALE; GASTROENTERITIS; HUMANS; LEUKOCYTE L1 ANTIGEN COMPLEX; MALE; NITRIC OXIDE; RECTUM; SWEDEN;

EID: 34250687797     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2007.00298.x     Document Type: Article

References (26)

1. Gillberg C, Coleman M. The biology of the autistic syndromes. 3rd ed. London : Mac Keith Press. Cambridge University Press, 2000 : 118 261.
2. Medical Research Council review of autism research: epidemiology and causes. London : MRC, 2001 : 21 64.
3. Shinnar S, Rapin I, Arnold S, Tuchman RF, Shulman L, Ballaban-Gil K, et al. 2001 Language regression in childhood. Pediatr Neurol 2001 24 : 183 89.
4. Wilson S, Djukic A, Shinnar S, Dharmani C, Rapin I. Clinical characteristics of language regression in children. Dev Med Child Neurol 2003 45 : 508 14.
5. Filipek PA, Accardo PJ, Ashwal S, Baranek GT, Cook EH Jr., Dawson G, et al. Practice parameter: screening and diagnosis of autism: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology 2000 55 : 468 79.
6. Wakefield AJ, Puleston JM, Montgomery SM, Anthony A, O'Leary JJ, Murch SH. Review article: the concept of entero-colonic encephalopathy, autism and opioid receptor ligands. Aliment Pharmacol Ther 2002 16 : 663 74.
7. Ashwood P, Anthony A, Torrente F, Wakefield AJ. Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10. J Clin Immunol 2004 24 : 664 73.
8. Furlano RI, Anthony A, Day R, Brown A, McGarvey L, Thomson MA, et al. Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. J Pediatr 2001 138 : 366 72.
9. Shattock P, Kennedy A, Rowell F, Berney TP. Role of neuropeptides in autism and their relationships with classical neurotransmitters. Brain Dysfunction 1991 3 : 328 45.
10. Bushara KO. Neurologic presentation of celiac disease. Gastroenterology 2005 128 : 92 7.
11. Horvath K, Papadimitriou JC, Rabsztyn A, Drachenberg C, Tildon JT. Gastrointestinal abnormalities in children with autistic disorder. J Pediatr 1999 135 : 559 63.
12. Kuddo T, Nelson KB. How common are gastrointestinal disorders in children with autism? Curr Opin Pediatr 2003 15 : 339 43.
13. Erickson CA, Stigler KA, Corkins MR, Posey DJ, Fitzgerald JF, McDougle CJ. Gastrointestinal factors in autistic disorder: a critical review. J Autism Dev Disord 2005 35 : 713 27.
14. Fombonne E, Chakrabarti S. 2001 No evidence for a new variant of measles-mumps-rubella-induced autism. Pediatrics 2001 108 : E58.
15. Taylor B, Miller E, Lingam R, Andrews N, Simmons A, Stowe J. Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. BMJ 2002 324 : 393 96.
16. Ljung T, Beijer E, Herulf M, Weitzberg E, Lundberg JO, Finkel Y, et al. Increased rectal nitric oxide in children with active inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2002 34 : 302 06.
17. Lundberg JO, Hellstrom PM, Fagerhol MK, Weitzberg E, Roseth AG. Technology insight: calprotectin, lactoferrin and nitric oxide as novel markers of inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol 2005 2 : 96 102.
18. American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders 1994. 4th ed. Washington, DC : American Psychiatric Association.
19. Herulf M, Ljung T, Hellström PM, Weitzberg E, Lundberg JO. Increased luminal nitric oxide in inflammatory bowel disease as shown with a novel minimally invasive method. Scand J Gastroenterol 1998 33 : 164 69.
20. Fagerberg UL, Lööf L, Merzoug RD, Hansson LO, Finkel Y. Fecal calprotectin levels in healthy children studied with an improved assay. J Pediatr Gastroenterol Nutr 2003 37 : 468 72.
21. Reinders CI, Hellstrom PM, Bjork J, Weitzberg E, Lundberg JO. Effect of intravenous L-NMMA on nitric oxide production in collagenous colitis. Scand J Gastroenterol 2004 39 : 32 6.
22. Bremner A, Roked S, Robinson R, Phillips I, Beattie M. Faecal calprotectin in children with chronic gastrointestinal symptoms. Acta Paediatr 2005 94 : 1855 8.
23. Anthony A, Bjarnason I, Sigthorsson G, Montgomery SM, Murch SH, Thompson M, et al. Faecal calprotectin levels correlate with acute inflammation in autistic enterocolitis. Gut 2000 46 (Suppl 2 A3.
24. Fagerberg UL, Lööf L, Myrdal U, Hansson LO, Finkel Y. Colorectal inflammation is well predicted by fecal calprotectin in children with gastrointestinal symptoms. J Pediatr Gastroenterol Nutr 2005 40 : 450 55.
25. Jyonouchi H, Geng L, Ruby A, Reddy C, Zimmerman-Bier B. Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. J Pediatr 2005 146 : 605 10.
26. Ashwood P, Wakefield AJ. Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms. J Neuroimmunol 2006 173 : 126 34.