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Volumn 61, Issue SUPPL. 154, 2007, Pages 29-37

Antihyperglycaemic therapy in elderly patients with type 2 diabetes: Potential role of incretin mimetics and DPP-4 inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; CHLORPROPAMIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1; INCRETIN; INSULIN; METFORMIN; NATEGLINIDE; PLACEBO; REPAGLINIDE; SITAGLIPTIN; SULFONYLUREA; VILDAGLIPTIN; ANTIDIABETIC AGENT;

EID: 34250677349     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2007.01437.x     Document Type: Review
Times cited : (39)

References (70)
  • 1
    • 33845472699 scopus 로고    scopus 로고
    • The burden and treatment of diabetes in elderly individuals in the U.S
    • Selvin E, Coresh J, Brancati FL. The burden and treatment of diabetes in elderly individuals in the U.S. Diabetes Care 2006 29 : 2415 9.
    • (2006) Diabetes Care , vol.29 , pp. 2415-9
    • Selvin, E.1    Coresh, J.2    Brancati, F.L.3
  • 2
    • 0033738860 scopus 로고    scopus 로고
    • Beta cell function declines with age in glucose tolerant Caucasians
    • Chiu KC, Lee NP, Cohan P, Chuang LM. Beta cell function declines with age in glucose tolerant Caucasians. Clin Endocrinol (Oxf) 2000 53 : 569 75.
    • (2000) Clin Endocrinol (Oxf) , vol.53 , pp. 569-75
    • Chiu, K.C.1    Lee, N.P.2    Cohan, P.3    Chuang, L.M.4
  • 4
    • 0036315001 scopus 로고    scopus 로고
    • Relationships among age, proinsulin conversion, and β-cell function in nondiabetic humans
    • Fritsche A, Madaus A, Stefan N et al. Relationships among age, proinsulin conversion, and β-cell function in nondiabetic humans. Diabetes 2002 51 (Suppl. 1 S234 9.
    • (2002) Diabetes , vol.51 , Issue.1
    • Fritsche, A.1    Madaus, A.2    Stefan, N.3
  • 5
    • 33748512579 scopus 로고    scopus 로고
    • Diabetes in the elderly
    • Meneilly GS. Diabetes in the elderly. Med Clin North Am 2006 90 : 909 23.
    • (2006) Med Clin North Am , vol.90 , pp. 909-23
    • Meneilly, G.S.1
  • 6
    • 0032951411 scopus 로고    scopus 로고
    • Metabolic alterations in middle-aged and elderly obese patients with type 2 diabetes
    • Meneilly GS, Elliott T. Metabolic alterations in middle-aged and elderly obese patients with type 2 diabetes. Diabetes Care 1999 22 : 112 8.
    • (1999) Diabetes Care , vol.22 , pp. 112-8
    • Meneilly, G.S.1    Elliott, T.2
  • 7
    • 19944378459 scopus 로고    scopus 로고
    • Metabolic alterations in middle-aged and elderly lean patients with type 2 diabetes
    • Meneilly GS, Elahi D. Metabolic alterations in middle-aged and elderly lean patients with type 2 diabetes. Diabetes Care 2005 28 : 1498 9.
    • (2005) Diabetes Care , vol.28 , pp. 1498-9
    • Meneilly, G.S.1    Elahi, D.2
  • 8
    • 0028009378 scopus 로고
    • Counterregulatory hormone responses to hypoglycemia in the elderly patient with diabetes
    • Meneilly GS, Cheung E, Tuokko H. Counterregulatory hormone responses to hypoglycemia in the elderly patient with diabetes. Diabetes 1994 43 : 403 10.
    • (1994) Diabetes , vol.43 , pp. 403-10
    • Meneilly, G.S.1    Cheung, E.2    Tuokko, H.3
  • 9
    • 0031024007 scopus 로고    scopus 로고
    • Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men
    • Matyka K, Evans M, Lomas J et al. Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men. Diabetes Care 1997 20 : 135 41.
    • (1997) Diabetes Care , vol.20 , pp. 135-41
    • Matyka, K.1    Evans, M.2    Lomas, J.3
  • 10
    • 1442299811 scopus 로고    scopus 로고
    • Heart failure prevalence, incidence, and mortality in the elderly with diabetes
    • Bertoni AG, Hundley WG, Massing MW et al. Heart failure prevalence, incidence, and mortality in the elderly with diabetes. Diabetes Care 2004 27 : 699 703.
    • (2004) Diabetes Care , vol.27 , pp. 699-703
    • Bertoni, A.G.1    Hundley, W.G.2    Massing, M.W.3
  • 11
    • 2342598455 scopus 로고    scopus 로고
    • The epidemiology of lower-extremity disease in veterans with diabetes
    • Mayfield JA, Reiber GE, Maynard C et al. The epidemiology of lower-extremity disease in veterans with diabetes. Diabetes Care 2004 27 : B39 44.
    • (2004) Diabetes Care , vol.27
    • Mayfield, J.A.1    Reiber, G.E.2    Maynard, C.3
  • 12
    • 32044465512 scopus 로고    scopus 로고
    • US Centers for Disease Control and Prevention. Department of Health and Human Services, Centers for Disease Control and Prevention, Available from:
    • US Centers for Disease Control and Prevention. Diabetes Public Health Resource: Data & Trends. Department of Health and Human Services, Centers for Disease Control and Prevention, 2004. Available from: http://www.cdc.gov/ diabetes/statistics/index.htm.
    • (2004) Diabetes Public Health Resource: Data & Trends.
  • 13
    • 0042023727 scopus 로고    scopus 로고
    • Racial differences in diabetic nephropathy, cardiovascular disease, and mortality in a national population of veterans
    • Young BA, Maynard C, Boyko EJ. Racial differences in diabetic nephropathy, cardiovascular disease, and mortality in a national population of veterans. Diabetes Care 2003 26 : 2392 9.
    • (2003) Diabetes Care , vol.26 , pp. 2392-9
    • Young, B.A.1    Maynard, C.2    Boyko, E.J.3
  • 14
    • 0842278037 scopus 로고    scopus 로고
    • Hospital outcome of acute myocardial infarction in patients with and without diabetes mellitus
    • Otter W, Kleybrink S, Doering W et al. Hospital outcome of acute myocardial infarction in patients with and without diabetes mellitus. Diabet Med 2004 21 : 183 7.
    • (2004) Diabet Med , vol.21 , pp. 183-7
    • Otter, W.1    Kleybrink, S.2    Doering, W.3
  • 15
    • 11144356305 scopus 로고    scopus 로고
    • The prevalence of diabetic retinopathy among adults in the United States
    • The Eye Diseases Prevalence Research Group.
    • The Eye Diseases Prevalence Research Group. The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol 2004 122 : 552 63.
    • (2004) Arch Ophthalmol , vol.122 , pp. 552-63
  • 16
    • 0027155903 scopus 로고
    • The effect of improved glycemic control on cognitive functions in the elderly patient with diabetes
    • Meneilly GS, Cheung E, Tessier D et al. The effect of improved glycemic control on cognitive functions in the elderly patient with diabetes. J Gerontol 1993 48 : M117 21.
    • (1993) J Gerontol , vol.48
    • Meneilly, G.S.1    Cheung, E.2    Tessier, D.3
  • 17
    • 3042589342 scopus 로고    scopus 로고
    • Changes in cognitive function by glucose tolerance status in older adults: A 4-year prospective study of the Rancho Bernardo study cohort
    • Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K. Changes in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort. Arch Intern Med 2004 164 : 1327 33.
    • (2004) Arch Intern Med , vol.164 , pp. 1327-33
    • Kanaya, A.M.1    Barrett-Connor, E.2    Gildengorin, G.3    Yaffe, K.4
  • 19
    • 0030852089 scopus 로고    scopus 로고
    • Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas
    • Shorr RI, Ray WA, Daugherty JR, Griffin MR. Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas. Arch Intern Med 1997 157 : 1681 6.
    • (1997) Arch Intern Med , vol.157 , pp. 1681-6
    • Shorr, R.I.1    Ray, W.A.2    Daugherty, J.R.3    Griffin, M.R.4
  • 20
    • 2342624692 scopus 로고    scopus 로고
    • Diabetes-related utilization and costs for inpatient and outpatient services in the Veterans Administration
    • Maciejewski ML, Maynard C. Diabetes-related utilization and costs for inpatient and outpatient services in the Veterans Administration. Diabetes Care 2004 27 : B69 73.
    • (2004) Diabetes Care , vol.27
    • MacIejewski, M.L.1    Maynard, C.2
  • 21
    • 0033522149 scopus 로고    scopus 로고
    • Effects of calcium channel blockade in older patients with diabetes and systolic hypertension
    • for the Systolic Hypertension in Europe Trial Investigators.
    • Tuomilehto J, Rastenyte D, Birkenhager WH et al. for the Systolic Hypertension in Europe Trial Investigators. Effects of calcium channel blockade in older patients with diabetes and systolic hypertension. N Engl J Med 1999 340 : 677 84.
    • (1999) N Engl J Med , vol.340 , pp. 677-84
    • Tuomilehto, J.1    Rastenyte, D.2    Birkenhager, W.H.3
  • 22
    • 0034638139 scopus 로고    scopus 로고
    • High blood pressure and diabetes mellitus: Are all antihypertensive drugs created equal
    • Grossman E, Messerli FH, Goldbourt U. High blood pressure and diabetes mellitus: are all antihypertensive drugs created equal Arch Intern Med 2000 160 : 2447 52.
    • (2000) Arch Intern Med , vol.160 , pp. 2447-52
    • Grossman, E.1    Messerli, F.H.2    Goldbourt, U.3
  • 23
    • 0034700790 scopus 로고    scopus 로고
    • Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: Results of the HOPE study and MICRO-HOPE substudy
    • Heart Outcomes Prevention Evaluation Study Investigators.
    • Heart Outcomes Prevention Evaluation Study Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 2000 355 : 253 9.
    • (2000) Lancet , vol.355 , pp. 253-9
  • 24
    • 0037840242 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 5963 people with diabetes: A randomised placebo-controlled trial
    • and the Heart Protection Study Collaborative Group.
    • Collins R, Armitage J, Parish S et al. and the Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003 361 : 2005 16.
    • (2003) Lancet , vol.361 , pp. 2005-16
    • Collins, R.1    Armitage, J.2    Parish, S.3
  • 25
    • 4344683381 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial
    • for the CARDS investigators.
    • Colhoun HM, Betteridge DJ, Durrington PN et al. for the CARDS investigators. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 2004 364 : 685 96.
    • (2004) Lancet , vol.364 , pp. 685-96
    • Colhoun, H.M.1    Betteridge, D.J.2    Durrington, P.N.3
  • 27
    • 0037968349 scopus 로고    scopus 로고
    • Guidelines for improving the care of the older person with diabetes mellitus
    • for the California Healthcare Foundation/American Geriatrics Society Panel on Improving Care for Elders with Diabetes.
    • Brown AF, Mangione CM, Saliba D, Sarkisian CA, for the California Healthcare Foundation/American Geriatrics Society Panel on Improving Care for Elders with Diabetes. Guidelines for improving the care of the older person with diabetes mellitus. J Am Geriatr Soc 2003 51 (5 Suppl. guidelines S265 80.
    • (2003) J Am Geriatr Soc , vol.51 , Issue.5
    • Brown, A.F.1    Mangione, C.M.2    Saliba, D.3    Sarkisian, C.A.4
  • 28
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group.
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998 352 : 837 53.
    • (1998) Lancet , vol.352 , pp. 837-53
  • 29
    • 0029015145 scopus 로고
    • Long-term instability of fasting plasma glucose predicts mortality in elderly NIDDM patients: The Verona Diabetes Study
    • Muggeo M, Verlato G, Bonara E et al. Long-term instability of fasting plasma glucose predicts mortality in elderly NIDDM patients: the Verona Diabetes Study. Diabetologia 1995 38 : 672 9.
    • (1995) Diabetologia , vol.38 , pp. 672-9
    • Muggeo, M.1    Verlato, G.2    Bonara, E.3
  • 30
    • 0028826119 scopus 로고
    • Long-term glycemic control relates to mortality in type II diabetes
    • Andersson DK, Svardsudd K. Long-term glycemic control relates to mortality in type II diabetes. Diabetes Care 1995 18 : 1534 43.
    • (1995) Diabetes Care , vol.18 , pp. 1534-43
    • Andersson, D.K.1    Svardsudd, K.2
  • 31
    • 0028069788 scopus 로고
    • NIDDM and its metabolic control predict coronary heart disease in elderly subjects
    • Kuusisto J, Mykkanen L, Pyorala K, Laakso M. NIDDM and its metabolic control predict coronary heart disease in elderly subjects. Diabetes 1994 43 : 960 7.
    • (1994) Diabetes , vol.43 , pp. 960-7
    • Kuusisto, J.1    Mykkanen, L.2    Pyorala, K.3    Laakso, M.4
  • 32
    • 0027360102 scopus 로고
    • Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus
    • Gradman TJ, Laws A, Thompson LW, Reaven GM. Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus. J Am Geriatr Soc 1993 41 : 1305 12.
    • (1993) J Am Geriatr Soc , vol.41 , pp. 1305-12
    • Gradman, T.J.1    Laws, A.2    Thompson, L.W.3    Reaven, G.M.4
  • 33
    • 3042823834 scopus 로고    scopus 로고
    • Hypoglycaemia in elderly patients with diabetes mellitus: Causes and strategies for prevention
    • Chelliah A, Burge MR. Hypoglycaemia in elderly patients with diabetes mellitus: causes and strategies for prevention. Drugs Aging 2004 21 : 511 30.
    • (2004) Drugs Aging , vol.21 , pp. 511-30
    • Chelliah, A.1    Burge, M.R.2
  • 34
    • 32144448938 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2006
    • American Diabetes Association.
    • American Diabetes Association. Standards of medical care in diabetes - 2006. Diabetes Care 2006 29 (Suppl. 1 S4 42.
    • (2006) Diabetes Care , vol.29 , Issue.1
  • 35
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes
    • Inzucchi SE. Oral antihyperglycemic therapy for type 2 diabetes. JAMA 2002 287 : 360 72.
    • (2002) JAMA , vol.287 , pp. 360-72
    • Inzucchi, S.E.1
  • 36
    • 13644263258 scopus 로고    scopus 로고
    • Oral antidiabetic agents: Current role in type 2 diabetes mellitus
    • Krentz AJ, Bailey CJ. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 2005 65 : 385 411.
    • (2005) Drugs , vol.65 , pp. 385-411
    • Krentz, A.J.1    Bailey, C.J.2
  • 37
    • 28444452977 scopus 로고    scopus 로고
    • Contraindications can damage your health - Is metformin a case in point
    • Holstein A, Stumvoll M. Contraindications can damage your health - is metformin a case in point Diabetologia. 2005 48 : 2454 9.
    • (2005) Diabetologia. , vol.48 , pp. 2454-9
    • Holstein, A.1    Stumvoll, M.2
  • 38
    • 33746588255 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB et al. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2006 29 : 1963 72.
    • (2006) Diabetes Care , vol.29 , pp. 1963-72
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 39
    • 2142769878 scopus 로고    scopus 로고
    • Treatment of patients over 64 years of age with type 2 diabetes: Experience from nateglinide pooled database retrospective analysis
    • Del Prato S, Heine RJ, Keilson L et al. Treatment of patients over 64 years of age with type 2 diabetes: experience from nateglinide pooled database retrospective analysis. Diabetes Care 2003 26 : 2075 80.
    • (2003) Diabetes Care , vol.26 , pp. 2075-80
    • Del Prato, S.1    Heine, R.J.2    Keilson, L.3
  • 40
    • 0035847591 scopus 로고    scopus 로고
    • Glucose tolerance and cardiovascular mortality: Comparison of fasting and 2-hour diagnostic criteria
    • The DECODE Study Group, for the European Diabetes Epidemiology Group.
    • The DECODE Study Group, for the European Diabetes Epidemiology Group. Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. Arch Intern Med 2001 161 : 397 405.
    • (2001) Arch Intern Med , vol.161 , pp. 397-405
  • 41
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial in macroVascular Events): A randomised controlled trial
    • for the PROactive investigators.
    • Dormandy JA, Charbonnel B, Eckland DJA et al. for the PROactive investigators. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005 366 : 1279 89.
    • (2005) Lancet , vol.366 , pp. 1279-89
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.A.3
  • 42
    • 26244444319 scopus 로고    scopus 로고
    • The PROactive study: Some answers, many questions
    • Yki-Järvinen H. The PROactive study: some answers, many questions. Lancet 2005 366 : 1241 2.
    • (2005) Lancet , vol.366 , pp. 1241-2
    • Yki-Järvinen, H.1
  • 43
    • 0141446228 scopus 로고    scopus 로고
    • Enhancing incretin action for the treatment of type 2 diabetes
    • Drucker DJ. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 2003 26 : 2929 40.
    • (2003) Diabetes Care , vol.26 , pp. 2929-40
    • Drucker, D.J.1
  • 44
    • 4544232468 scopus 로고    scopus 로고
    • Inhibitors of dipeptidyl peptidase IV: A novel approach for the prevention and treatment of type 2 diabetes
    • Deacon CF, Ahrén B, Holst JJ. Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of type 2 diabetes Expert Opin Investig Drugs 2004 13 : 1091 102.
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 1091-102
    • Deacon, C.F.1    Ahrén, B.2    Holst, J.J.3
  • 45
    • 12244268666 scopus 로고    scopus 로고
    • On the physiology of GIP and GLP-1
    • Holst JJ. On the physiology of GIP and GLP-1. Horm Metab Res 2004 36 : 747 54.
    • (2004) Horm Metab Res , vol.36 , pp. 747-54
    • Holst, J.J.1
  • 46
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006 368 : 1696 705.
    • (2006) Lancet , vol.368 , pp. 1696-705
    • Drucker, D.J.1    Nauck, M.A.2
  • 47
    • 33645707285 scopus 로고    scopus 로고
    • Vildagliptin: An inhibitor of dipeptidyl peptidase-4 with antidiabetic properties
    • Ahrén B. Vildagliptin: an inhibitor of dipeptidyl peptidase-4 with antidiabetic properties. Expert Opin Investig Drugs 2006 15 : 431 42.
    • (2006) Expert Opin Investig Drugs , vol.15 , pp. 431-42
    • Ahrén, B.1
  • 48
    • 33749834648 scopus 로고    scopus 로고
    • DPP-4 inhibitors and their potential role in the management of type 2 diabetes
    • Barnett A. DPP-4 inhibitors and their potential role in the management of type 2 diabetes. Int J Clin Pract 2006 60 : 1454 70.
    • (2006) Int J Clin Pract , vol.60 , pp. 1454-70
    • Barnett, A.1
  • 49
    • 0141669196 scopus 로고    scopus 로고
    • Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes
    • Meneilly GS, Greig N, Tildesley H et al. Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes. Diabetes Care 2003 26 : 2835 41.
    • (2003) Diabetes Care , vol.26 , pp. 2835-41
    • Meneilly, G.S.1    Greig, N.2    Tildesley, H.3
  • 50
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck MA, Heimesaat MM, Behle K et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab 2002 87 : 1239 46.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1239-46
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3
  • 51
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004 27 : 2628 35.
    • (2004) Diabetes Care , vol.27 , pp. 2628-35
    • Buse, J.B.1    Henry, R.R.2    Han, J.3
  • 52
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J et al. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005 28 : 1092 100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-100
    • Defronzo, R.A.1    Ratner, R.E.2    Han, J.3
  • 53
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005 28 : 1083 91.
    • (2005) Diabetes Care , vol.28 , pp. 1083-91
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3
  • 54
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L, Klein EJ, Han J et al. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab 2006 8 : 436 47.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 436-47
    • Blonde, L.1    Klein, E.J.2    Han, J.3
  • 56
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: A randomized trial
    • for the GWAA Study Group.
    • Heine RJ, Van Gaal LF, Johns D et al. for the GWAA Study Group. Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med 2005 143 : 559 69.
    • (2005) Ann Intern Med , vol.143 , pp. 559-69
    • Heine, R.J.1    Van Gaal, L.F.2    Johns, D.3
  • 57
    • 33750973254 scopus 로고    scopus 로고
    • Safety and effects of a once-weekly, long-acting release formulation of exenatide over 15 weeks in patients with type 2 diabetes
    • Abstract 487-P).
    • Kim D, Macconell L, Zhuang D et al. Safety and effects of a once-weekly, long-acting release formulation of exenatide over 15 weeks in patients with type 2 diabetes. Diabetes 2006 55 (Suppl. 1 116 (Abstract 487-P).
    • (2006) Diabetes , vol.55 , Issue.1 , pp. 116
    • Kim, D.1    MacConell, L.2    Zhuang, D.3
  • 58
    • 33750288460 scopus 로고    scopus 로고
    • Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes
    • and the N2211-1499 Study Group.
    • Nauck MA, Hompesch M, Filipczak R et al. and the N2211-1499 Study Group. Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes. Exp Clin Endocrinol Diabetes 2006 114 : 417 23.
    • (2006) Exp Clin Endocrinol Diabetes , vol.114 , pp. 417-23
    • Nauck, M.A.1    Hompesch, M.2    Filipczak, R.3
  • 59
    • 33845980289 scopus 로고    scopus 로고
    • Liraglutide significantly improves glycemic control, and lowers body weight without risk of either major or minor hypoglycemic episodes in subjects with type 2 diabetes
    • Abstract 115-OR).
    • Vilsboll T, Zdravkovic M, Le-Thi T et al. Liraglutide significantly improves glycemic control, and lowers body weight without risk of either major or minor hypoglycemic episodes in subjects with type 2 diabetes. Diabetes 2006 55 (Suppl. 1 A27 8 (Abstract 115-OR).
    • (2006) Diabetes , vol.55 , Issue.1
    • Vilsboll, T.1    Zdravkovic, M.2    Le-Thi, T.3
  • 60
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • for the Sitagliptin Study 021 Group.
    • Aschner P, Kipnes MS, Lunceford JK et al. for the Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 2006 29 : 2632 7.
    • (2006) Diabetes Care , vol.29 , pp. 2632-7
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3
  • 61
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • for the Sitagliptin Study 020 Group.
    • Charbonnel B, Karasik A, Liu J et al. for the Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 2006 29 : 2638 43.
    • (2006) Diabetes Care , vol.29 , pp. 2638-43
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3
  • 62
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • and Sitagliptin Study 019 Group.
    • Rosenstock J, Brazg R, Andryuk PJ et al. and Sitagliptin Study 019 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2006 28 : 1556 68.
    • (2006) Clin Ther , vol.28 , pp. 1556-68
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3
  • 64
    • 33748316958 scopus 로고    scopus 로고
    • Sustained reduction in HbA1c during one-year treatment with vildagliptin in patients with type 2 diabetes (T2DM)
    • Abstract 120-OR).
    • Dejager S, Lebeaut A, Couturier A, Schweizer A. Sustained reduction in HbA1c during one-year treatment with vildagliptin in patients with type 2 diabetes (T2DM). Diabetes 2006 55 (Suppl. 1 A29 (Abstract 120-OR).
    • (2006) Diabetes , vol.55 , Issue.1
    • Dejager, S.1    Lebeaut, A.2    Couturier, A.3    Schweizer, A.4
  • 66
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E, Camisasca RP, Collober C et al. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 2007 30 : 890 5.
    • (2007) Diabetes Care , vol.30 , pp. 890-5
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3
  • 67
    • 34250641853 scopus 로고    scopus 로고
    • Effect of vildagliptin monotherapy on body weight in drug-naïve patients with type 2 diabetes (T2DM)
    • Cape Town, South Africa, 3-7 December, (Abstract 826).
    • Foley JE, Dejager S, Chang I, Schweizer A. Effect of vildagliptin monotherapy on body weight in drug-naïve patients with type 2 diabetes (T2DM). Presented at the 19th World Diabetes Congress, Cape Town, South Africa, 3-7 December, 2006 (Abstract 826).
    • (2006) Presented at the 19th World Diabetes Congress
    • Foley, J.E.1    Dejager, S.2    Chang, I.3    Schweizer, A.4
  • 68
    • 33748318306 scopus 로고    scopus 로고
    • The influence of hepatic impairment on the pharmacokinetics of vildagliptin
    • Abstract 2024-PO).
    • He YL, Sabo R, Wang Y et al. The influence of hepatic impairment on the pharmacokinetics of vildagliptin. Diabetes 2006 55 (Suppl. 1 A469 (Abstract 2024-PO).
    • (2006) Diabetes , vol.55 , Issue.1
    • He, Y.L.1    Sabo, R.2    Wang, Y.3
  • 69
    • 33751102318 scopus 로고    scopus 로고
    • Influence of age, gender and BMI on the pharmacokinetics and pharmacodynamics of vildagliptin
    • Abstract PIII-19).
    • He YL, Sabo R, Wang Y. Influence of age, gender and BMI on the pharmacokinetics and pharmacodynamics of vildagliptin. Clin Pharmacol Ther 2006 79 : P63 (Abstract PIII-19).
    • (2006) Clin Pharmacol Ther , vol.79
    • He, Y.L.1    Sabo, R.2    Wang, Y.3
  • 70
    • 34250672719 scopus 로고    scopus 로고
    • Efficacy and tolerability of the DPP-4 inhibitor vildagliptin in drug-naïve patients with type 2 diabetes aged 65 and older
    • Abstract P805).
    • Baron M, Dejager S, Chang I et al. Efficacy and tolerability of the DPP-4 inhibitor vildagliptin in drug-naïve patients with type 2 diabetes aged 65 and older. Diabet Med 2006 23 (Suppl. 4 295 (Abstract P805).
    • (2006) Diabet Med , vol.23 , Issue.4 , pp. 295
    • Baron, M.1    Dejager, S.2    Chang, I.3


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