Primary pulmonary and mediastinal synovial sarcoma: A clinicopathologic study of 60 cases and comparison with five prior series

Modern Pathology

Volumn 20, Issue 7, 2007, Pages 760-769

  Hartel, Paul H ^a   Fanburg Smith, Julie C ^a   Frazier, Aletta A ^a,b   Galvin, Jeffrey R ^a,b   Lichy, Jack H ^a   Shilo, Konstantin ^a   Franks, Teri J ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Mediastinum; Pleura; Pulmonary; Synovial sarcoma

Indexed keywords

CALRETININ; CD56 ANTIGEN; CD99 ANTIGEN; CYTOKERATIN; CYTOKERATIN 5; CYTOKERATIN 6; CYTOKERATIN 7; EPITHELIAL MEMBRANE ANTIGEN; PANCYTOKERATIN; PROTEIN BCL 2; PROTEIN S 100; SMOOTH MUSCLE ACTIN; UNCLASSIFIED DRUG;

ADENOMATOID TUMOR; ADULT; AGE DISTRIBUTION; ANTIGEN EXPRESSION; ARTICLE; CALCIFICATION; CANCER DIAGNOSIS; CANCER MORTALITY; CELL DENSITY; CELL STRUCTURE; CHROMOSOME 18; CHROMOSOME TRANSLOCATION; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HEMANGIOPERICYTOMA; HISTOLOGY; HUMAN; HUMAN TISSUE; HYALINE DEGENERATION; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS CELL; LUNG SARCOMA; MALE; MAST CELL; MEDIASTINUM TUMOR; MYXOSARCOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHABDOID TUMOR; ROSETTE FORMATION; SEX DIFFERENCE; SYNOVIAL SARCOMA; THORAX RADIOGRAPHY; TUMOR VASCULARIZATION; X CHROMOSOME;

ADULT; ANTIGENS, CD; ANTIGENS, CD56; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CELL ADHESION MOLECULES; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, X; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LUNG NEOPLASMS; MALE; MEDIASTINAL NEOPLASMS; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS C-BCL-2; S100 PROTEINS; SARCOMA, SYNOVIAL; SURVIVAL RATE; TRANSLOCATION, GENETIC;

EID: 34250671522     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800795     Document Type: Article

References (30)

1. Weiss SW, Goldblum JR (eds). Enzinger and Weiss's Soft Tissue Tumors, 4th edn. Mosby: St Louis, MO, 2001, pp 1502-1504.
2. Travis WD, Brambilla E, Muller-Hermelink HK, et al. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Lung, Pleura, Thymus, and Heart. IARC Press: Lyon, France, 2004, p 344.
3. Zeren H, Moran CA, Suster S, et al. Primary pulmonary sarcomas with features of monophasic synovial sarcoma: a clinicopathological, immunohistochemical, and ultrastructural study of 25 cases. Hum Pathol 1995;26:474-480.
4. Begueret H, Galateau-Salle F, Guillou L, et al. Primary intrathoracic synovial sarcoma: a clinicopathologic study of 40 t(x;18)-positive cases from the French Sarcoma Group and the Mesopath Group. Am J Surg Pathol 2005;29:339-346.
5. Essary LR, Vargas SO, Fletcher CD. Primary pleuropulmonary synovial sarcoma: reappraisal of a recently described anatomic subset. Cancer 2002;94:459-469.
6. Okamoto S, Hisaoka M, Daa T, et al. Primary pulmonary synovial sarcoma: a clinicopathologic, immunohistochemical, and molecular study of 11 cases. Hum Pathol 2004;35:850-856.
7. Suster S, Moran CA. Primary synovial sarcomas of the mediastinum: a clinicopathologic, immunohistochemical, and ultrastructural study of 15 cases. Am J Surg Pathol 2005;29:569-578.
8. Fletcher CD, Unni KK, Mertens FE. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Soft Tissue and Bone. IARC Press: Lyon, France, 2002, p 427.
9. Bijwaard KE, Fetsch JF, Przygodzki R, et al. Detection of SYT-SSX fusion transcripts in archival synovial sarcomas by real-time reverse transcriptase-polymerase chain reaction. J Mol Diagn 2002;4:59-64.
10. Miettinen ME. Diagnostic Soft Tissue Pathology. Churchill Livingstone: New York, 2003, pp 463-468.
11. Nicholson AG, Rigby M, Lincoln C, et al. Synovial sarcoma of the heart. Histopathology 1997;30:349-352.
12. Frazier AA, Franks TJ, Pugatch RD, et al. From the archives of the AFIP: pleuropulmonary synovial sarcoma. Radiographics 2006;26:923-940.
13. Duran-Mendicuti A, Costello P, Vargas SO. Primary synovial sarcoma of the chest: radiographic and clinicopathologic correlation. J Thorac Imaging 2003;18:87-93.
14. Nicholson AG, Goldstraw P, Fisher C. Synovial sarcoma of the pleura and its differentiation from other primary pleural tumours: a clinicopathological and immunohistochemical review of three cases. Histopathology 1998;33:508-513.
15. Zaring RA, Roepke JE. Pathologic quiz case. Pulmonary mass in a patient presenting with a hemothorax. Diagnosis: primary pulmonary biphasic synovial sarcoma. Arch Pathol Lab Med 1999;123:1287-1289.
16. Gaertner E, Zeren EH, Fleming MV, et al. Biphasic synovial sarcomas arising in the pleural cavity. A clinicopathologic study of five cases. Am J Surg Pathol 1996;20:36-45.
17. Fujimoto K, Hashimoto S, Abe T, et al. Synovial sarcoma arising from the chest wall: MR imaging findings. Radiat Med 1997;15:411-414.
18. Murphey MD, Jelinek JS, Kransdorf MJ, et al. Imaging of synovial sarcoma (abstract). Radiology 1998;209(P):421.
19. Smith TA, Machen SK, Fisher C, et al. Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from malignant peripheral nerve sheath tumor. Am J Clin Pathol 1999;112:641-648.
20. Kleihues P, Cavenee WK. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Nervous System. IARC Press: Lyon, France, 2000, pp 172-174.
21. Machen SK, Fisher C, Gautam RS, et al. Utility of cytokeratin subsets for distinguishing poorly differentiated synovial sarcoma from peripheral primitive neuroectodermal tumour. Histopathology 1998;33:501-507.
22. Hasegawa T, Yamamoto S, Yokoyama R, et al. Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer 2002;95:843-851.
23. Kawai A, Woodruff J, Healey JH, et al. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med 1998;338:153-160.
24. Ladanyi M, Antonescu CR, Leung DH, et al. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res 2002;62:135-140.
25. Nilsson G, Skytting B, Xie Y, et al. The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome. Cancer Res 1999;59:3180-3184.
26. Panagopoulos I, Mertens F, Isaksson M, et al. Clinical impact of molecular and cytogenetic findings in synovial sarcoma. Genes Chromosomes Cancer 2001;31:362-372.
27. Guillou L, Benhattar J, Bonichon F, et al. Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. J Clin Oncol 2004;22:4040-4050.
28. De Alava E, Kawai A, Healey JH, et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J Clin Oncol 1998;16:1248-1255.
29. Kelly KM, Womer RB, Sorensen PH, et al. Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma. J Clin Oncol 1997;15:1831-1836.
30. Melo JV. The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. Blood 1996;88:2375-2384.