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0030694323
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Ellman has demonstrated the advantageous use of (R)- or (S)-tert-butanesulfinamide for aliphatic α-chiral amine synthesis, see: a) G. Liu, D. A. Cogan, J. A. Ellman, J. Am. Chem. Soc. 1997, 119, 9913-9914;
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For further examples of enantioselective carbanion addition to aliphatic aldimines, see: a
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84985624865
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For further examples of diastereoselective carbanion addition to chiral imines, see: a
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For further examples of diastereoselective carbanion addition to chiral imines, see: a) D. Enders, H. Schubert, C. Nübling, Angew. Chem. Int. Ed. Engl. 1986, 25, 1109-1110;
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34250686999
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[2a,2b,5a].
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[2a,2b,5a].
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33
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35
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34250644244
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[2c].
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[2c].
-
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36
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0004228992
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R. J. K. Taylor Ed, Oxford University Press, Oxford
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R. J. K. Taylor (Ed.), Organocopper Reagents, Oxford University Press, Oxford, 1994.
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Organocopper Reagents
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38
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34250644860
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[17]
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[17]
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39
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34250646512
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In all instances the major amine diastereomer, S,S-2, could be isolated in analytically pure form by using flash chromatography or by recrystallization of the HCl or HBr salt. An exception to this general rule was noted for amine 2f, which could not be further enriched
-
In all instances the major amine diastereomer, (S,S)-2, could be isolated in analytically pure form by using flash chromatography or by recrystallization of the HCl or HBr salt. An exception to this general rule was noted for amine 2f, which could not be further enriched.
-
-
-
-
40
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27644565224
-
-
[11c], and by extrapolation for compounds 2a, 2b, 2d, 2f, and 2g.
-
[11c], and by extrapolation for compounds 2a, 2b, 2d, 2f, and 2g.
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-
-
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41
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34250637814
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A previous investigation with the corresponding preformed imine resulted in the same de, even though the compounds were added in the reverse order, see ref.[11b
-
[11b]
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