A CMOS-based microelectrode array for interaction with neuronal cultures

Journal of Neuroscience Methods

Volumn 164, Issue 1, 2007, Pages 93-106

  Hafizovic, S ^a   Heer, F ^a   Ugniwenko, T ^b   Frey, U ^a   Blau, A ^b   Ziegler, C ^b   Hierlemann, A ^a  

^a ETH ZURICH   (Switzerland)

^b Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

Author keywords

CMOS; Event detection; Extracellular recording; Liquid state machine; Microelectrode array; Support vector machine

Indexed keywords

ANALOG COMPUTER; ANALOG DIGITAL CONVERTER; ARTICLE; CELL STIMULATION; COMPUTER INTERFACE; COMPUTER PROGRAM; DIGITAL COMPUTER; ELECTROSTIMULATION; EVENT RELATED POTENTIAL; HEART MUSCLE CELL; MEMBRANE CURRENT; MICROELECTRODE; MOLECULAR INTERACTION; NERVE CELL CULTURE; PRIORITY JOURNAL; SIGNAL DETECTION; SUPPORT VECTOR MACHINE; VIDEORECORDING;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; CELL CULTURE TECHNIQUES; CELLS, CULTURED; ELECTRONICS, MEDICAL; ELECTROPHYSIOLOGY; MICROELECTRODES; NERVE NET; NEURONS; NEUROPHYSIOLOGY; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SIGNAL PROCESSING, COMPUTER-ASSISTED; SOFTWARE;

EID: 34250642313     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2007.04.006     Document Type: Article

References (45)

1. Ashenden P.J. The designer's guide to VHDL. 2nd ed. (2002), Morgan Kaufmann
2. Baumann W., Schreiber E., Krause G., Podssun A., Homma S., Schrott R., et al. Cell monitoring system with multiparametric CMOS sensorchips. μTAS 2 (2004) 554-556
3. Berdondini L., der Wal P.V., Guenat O., de Rooij N., Koudelka-Hep M., Seitz P., et al. High-density electrode array for imaging in vitro electrophysiological activity. Biosens Bioelectron 21 (2005) 167-174
4. Bonifazi P., and Fromherz P. Silicon chip for electronic communication between nerve cells by non-invasive interfacing and analog-digital processing. Adv Mater 14 17 (2002) 1190-1193
5. Buitenweg J., Rutten W., and Marani E. Extracellular stimulation window explained by a geometry-based model of the Neuron-electrode contact. IEEE Transact Biomed Eng 49 (2002) 1591-1599
6. Buitenweg J., Rutten W., Marani E., Polman S., and Ursum J. Extracellular detection of active membrane currents in the neuron-electrode interface. J Neurosci Meth 115 (2002) 211-221
7. CESYS GmbH, 2005. CESYS USB2 board combining a Xilinx Spartan II, XC2S200 with a Cypress FX-2 chip set. Herzogenaurach, Germany.
8. Claverol-Tinture E., and Pine J. Extracellular potentials in low-density dissociated neuronal cultures. J Neurosci Meth 117 1 (2002) 13-21
9. Epotek, 2007. Epotek, Billerica, MA, USA. http://www.epotek.com
10. Eversmann B., Jenkner M., Hofmann F., Paulus C., Brederlow R., Holzapfl B., et al. A 128 × 128 CMOS biosensor array for extracellular recording of neural activity. IEEE J Solid-State Circuits 38 (2003) 2306-2317
11. Gross G.W., Rieske E., Kreutzberg G.W., and Meyer A. A new fixed-array multi-microelectrode system designed for long-term monitoring of extracellular single unit neuronal activity in vitro. Neurosci Lett 6 (1977) 101-105
12. Gross G., Rhoades B., Reust D., and Schwalm F. Stimulation of monolayer networks in culture through thin-film indium-tin oxide recording electrodes. J Neurosci Meth 50 (1993) 131-143
13. Hafizovic, S, 2005. Ce USB kit. http://sourceforge.net/projects/ce-usb-kit.
14. Heer F., Franks W., Blau A., Taschini S., Ziegler C., Hierlemann A., et al. CMOS microelectrode array for the monitoring of electrogenic cells. Biosens Bioelectron 20 (2004) 358-366
15. Heer F., Hafizovic S., Franks W., Blau A., Ziegler C., and Hierlemann A. CMOS microelectrode array for bidirectional interaction with neuronal networks. IEEE J Solid-State Circuits 41 (2006) 1620-1629
16. Hodgkin A., and Huxley A. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117 (1952) 500-544
17. James C., Spence A., Dowell-Mesfin N., Hussain R., Smith K., Craighead H., et al. Extracellular recordings from patterned neuronal networks using planar microelectrode arrays. IEEE Transact Biomed Eng 51 (2004) 1640-1648
18. Jimbo Y., and Kawana A. Electrical-stimulation and recording from cultured neurons using a planar electrode array. Bioelectrochem Bioenerg 29 (1992) 193-204
19. Jimbo Y., Kasai N., Torimitsu K., Tateno T., and Robinson H. A system for MEA-based multisite stimulation. IEEE Transact Biomed Eng 50 (2003) 241-248
20. Kandel E., Schwartz J., and Jessell T. Principles of neural science (2000), McGraw-Hill Companies
21. Kovacs G. Electronic sensors with living cellular components. Proc IEEE 91 (2003) 915-929
22. Lewicki M.S. A review of methods for spike sorting: the detection and classification of neural action potentials. Comput Neural Syst (1998) 53-78
23. Maass W., Natschlager T., and Markram H. Real-time computing without stable states: a new framework for neural computation based on perturbations. Neural Comput 14 30 (2002) 2531-2560
24. Maass W., Natschläeger T., and Markram H. A model for real-time computation in generic neural microcircuits. Adv Neural Inform Process Syst 15 (2003) 229-236
25. Maher M., Pine J., Wright J., and Tai Y.-C. The neurochip: a new multielectrode device for stimulating and recording from cultured neurons. J Neurosci Meth 87 (1999) 45-56
26. Marom S., and Shahaf G. Development, learning and memory in large random networks of cortical neurons: lessons beyond anatomy. Quart Rev Biophys 35 (2002) 63-87
27. McIntyre C.C., and Grill W.M. Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. J Neurophysiol 88 4 (2002) 1592-1604
28. MCS, 2006. Multi Channel Systems GmbH, Reutlingen, Germany. http://www.multichannelsystems.com.
29. Mentor Graphics Corp., 2004. Modelsim se plus 6.0a. Wilsonville, Oregon, USA.
30. Morin F., Takamura Y., and Tamiya E. Investigating neuronal activity with planar microelectrode arrays: achievements and new perspectives. Biosci Bioeng 100 2 (2005) 131-143
31. Nilson R., Björkegren J., and Tegnér J. A flexible implementation for support vector machines. Math J 10 1 (2006)
32. Potter S.M. Distributed processing in cultured neuronal networks. Prog Brain Res 130 (2001) 49-62
33. Potter S.M., and DeMarse T.B. A new approach to neural cell culture for long-term studies. J Neurosci Meth 110 (2001) 17-24
34. Stett A., Egert U., Guenther E., Hofmann F., Meyer T., Nisch W., et al. Biological application of microelectrode arrays in drug discovery and basic research. Anal Bioanal Chem V377 (2003 (October)) 486-495
35. Synplicity, I, 2005. Synplify 8.1. California, USA.
36. Taketani M., and Baudry M. Advances in network electrophysiology (2006), Springer, New York
37. Taschini S., Emmenegger M., Baltes H., and Korvink J.G. Smart enumeration in C++: virtual construction, message dispatching and tables. Software-Pract Exper 29 (1999) 67-76
38. Trolltech, Inc., 2007. Qt 4.2. Oslo, Norway.
39. USB Implementers Forum, 2005. USB specification. http://www.usb.org/developers/docs.
40. Wagenaar D., and Potter S. A versatile all-channel stimulator for electrode arrays, with real-time control. J Neural Eng 1 1 (2004) 39-45
41. Wagenaar D., Pine J., and Potter S. Effective parameters for stimulation of dissociated cultures using multi-electrode arrays. J Neurosci Meth 138 1-2 (2004 (September)) 27-37
42. Wagenaar D., Pine J., and Potter S. Searching for plasticity in dissociated cortical cultures on multi-electrode arrays. J Neg Results BioMed 5 1 (2006) 16
43. Wolfram Research, I., 2005. Mathematica 5.2. Champaign, USA.
44. XFAB, 2007. 0.6 μim process, triple-metal, double-polysilicon CMOS process. Dresden, Germany.
45. Xilinx, 2005. Xilinx ISE 7.1. San Jose, Califonia, USA.