New engineered particles from spray dryers: Research needs in spray drying

Drying Technology

Volumn 25, Issue 6, 2007, Pages 971-983

  Langrish, T A G ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Agglomeration; Computational fluid dynamics; Product development; Reaction engineering; Spray dryer; Stickiness; Wall deposition

Indexed keywords

AGGLOMERATION; COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; FLOW PATTERNS; PARTICLES (PARTICULATE MATTER); PYROLYSIS; SPRAY DRYING;

DRYING KINETICS; REACTION ENGINEERING;

DRYERS (EQUIPMENT);

AGGLOMERATION; COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; DRYERS (EQUIPMENT); FLOW PATTERNS; PARTICLES (PARTICULATE MATTER); PYROLYSIS; SPRAY DRYING;

EID: 34250632776     PISSN: 07373937     EISSN: 15322300     Source Type: Journal    
DOI: 10.1080/07373930701396766     Document Type: Review

References (71)

1. Bahu, R.E. (1992) Drying '92, Proceedings of the 8th International Drying Symposium (IDS '92), pp. 74-91. Amsterdam, Elsevier
2. Oakley, D.E. (1994) Scale-up of spray dryers with the aid of computational fluid dynamics. Drying Technology, 12:1, pp. 217-233.
3. Keey, R.B. and Pham, Q.T. (1976) Behaviour of spray dryers with nozzle atomizers. Chemical Engineering, 311, pp. 516-521.
4. Place, G., Ridgway, K. and Danckwerts, P.V. (1959) Investigation of air-flow in a spray-drier by tracer and model techniques. Transactions of the Institution of Chemical Engineers, 37:5, pp. 268-276.
5. Paris, J.R., Ross, P.N., Dastur, S.P. and Morris, R.L. (1971) Modelling of the air flow pattern in a countercurrent spray-drying tower. Industrial Engineering Chemistry Process Design and Developopment, 10:2, pp. 157-164.
6. Reay, D. (1988) Proceedings of the 6th International Drying Symposium (IDS '88), Versailles, France
7. Crowe, C.T. (1980) Advances in Drying, 1, pp. 63-99. Hemisphere, New York
8. Bradshaw, P., Launder, B.E. and Lumley, J.L. (1996) Collaborative testing of turbulence models. Journal of Fluids Engineering, Transactions of the American Society of Mechanical Engineers, 118:2, pp. 243-247.
9. Oakley, D.E., Bahu, R.E. and Reay, D. (1988) Proceedings of the 6th International Drying Symposium (IDS '88), pp. OP373-OP378. Versailles, France
10. Oakley, D.E. and Bahu, R.E. (1991) Drying '91, pp. 303-313. Elsevier, Amsterdam
11. Livesley, D.M., Oakley, D.E., Gillespie, R.F., Elhaus, B., Ranpuria, C.K., Taylor, T., Wood, W. and Yeoman, M.L. (1992) Drying '92, Proceedings of the 8th International Drying Symposium (IDS '92), pp. 407-416. Amsterdam, Elsevier
12. Huang, L., Kumar, K. and Mujumdar, A.S. (2003) A parametric study of the gas flow patterns and drying performance of co-current spray dryer: Results of a computational fluid dynamics study. Drying Technology, 21:7, pp. 957-978.
13. Bayly, A., Jukes, P., Groombridge, M. and McNally, C. (2004) Drying 2004, Proceedings of the 14th International Drying Symposium (IDS 2004), pp. 775-781. Sao Paulo, Brazil
14. Harvie, D.J.E., Langrish, T.A.G. and Fletcher, D.F. (2002) A computational fluid dynamics study of a tall-form spray dryer. Transactions of the Institution of Chemical Engineers, 80, pp. 163-175.
15. Langrish, T.A.G., Oakley, D.E., Keey, R.B., Bahu, R.E. and Hutchinson, C.A. (1993) Time-dependent flow patterns in spray dryers. Transactions of the Institution of Chemical Engineers, 71, pp. 355-360.
16. Guo, B., Langrish, T.A.G. and Fletcher, D.F. (2001) An assessment of turbulence models applied to the simulation of a two-dimensional jet. Applied Mathematical Modelling, 25:8, pp. 635-653.
17. Guo, B., Langrish, T.A.G. and Fletcher, D.F. (2001) Numerical simulation of unsteady turbulent flow in axisymmetric sudden expansions. American Society of Mechanical Engineers (ASME) Journal of Fluids Engineering, 123:3, pp. 574-587.
18. Guo, B., Langrish, T.A.G. and Fletcher, D.F. (2001) Simulation of turbulent swirl flow in an axisymmetric sudden expansion. American Institute of Aeronautics and Astronautics Journal, 39, pp. 96-102.
19. LeBarbier, C., Kockel, T.K., Fletcher, D.F. and Langrish, T.A.G. (2001) Experimental measurement and numerical simulation of the effect sof swirl on flow stability in spray dryers. Transactions of the Institution of Chemical Engineers, 79, pp. 260-268.
20. Dellenback, P.S., Metzger, D.E. and Neitzel, G.P. (1988) Measurement in turbulent swirling flow through an abrupt axisymmetric expansion. American Institute of Aeronautics and Astronautics Journal, 26:6, pp. 669-681.
21. Goldberg, J.E. (1987) Prediction of Spray Dryer Performance, University of Oxford, Oxford, England
22. Langrish, T.A.G., Keey, R.B. and Hutchinson, C.A. (1992) Flow visualization in a spray dryer fitted with a vaned-wheel atomizer. Transactions of the Institution of Chemical Engineers, 70, pp. 385-394.
23. Oakley, D.E. and Keey, R.B. (1996) Drying '96, Proceedings of the 10th International Drying Symposium (IDS '96), pp. 513-520. Kraków, Poland
24. Huang, L.X., Passos, M.L., Kumar, K. and Mujumdar, A.S. (2005) A three-dimensional simulation of a spray dryer fitted with a rotary atomizer. Drying Technology, 23:9, pp. 1859-1873.
25. Huang, L.X., Kumar, K. and Mujumdar, A.S. (2006) A comparative study of a spray dryer with rotary disc atomizer and pressure nozzle using computational fluid dynamic simulations. Chemical Engineering and Processing, 45:6, pp. 460-471.
26. Huang, L.X. and Mujumdar, A.S. (2006) Numerical study of two-stage horizontal spray dryers using computational fluid dynamics. Drying Technology, 24:6, pp. 727-733.
27. Langrish, T.A.G. and Fletcher, D.F. (2003) Prospects for the modelling and design of spray dryers in the 21st century. Drying Technology, 21:2, pp. 197-215.
28. Fletcher, D.F., Guo, B., Harvie, D., Langrish, T.A.G., Nijdam, J.J. and Williams, J. (2006) What is important in the simulation of spray dryer performance and how do current CFD models perform?. Applied Mathematical Modelling, 30:11, pp. 1281-1292.
29. Nijdam, J.J., Guo, B., Fletcher, D.F. and Langrish, T.A.G. (2004) Challenges of simulating droplet coalescence within a spray. Drying Technology, 22:6, pp. 1463-1488.
30. Nijdam, J.J., Guo, B., Fletcher, D.F. and Langrish, T.A.G. (2006) Validation of the Lagrangian approach for predicting turbulent dispersion and evaporation of droplets within a spray. Drying Technology, 24:11, pp. 1373-1379.
31. Nijdam, J.J., Guo, B., Fletcher, D.F. and Langrish, T.A.G. (2006) Lagrangian and Eulerian models for simulating turbulent dispersion and agglomeration of droplets within a spray. Applied Mathematical Modelling, 30:11, pp. 1196-1211.
32. Verdurmen, R.E.M., Menn, P., Ritzert, J., Blei, S., Nhumajo, G.C.S., Sorensen, T.S., Gunsing, M., Straatsma, J., Vershueren, M., Sibeijn, M., Schulte, G., Fritsching, U., Bauckhage, K., Tropea, C., Sommerfeld, M., Watkins, A.P., Yule, A.J. and Schonfeldt, H. (2004) Simulation of agglomeration in spray drying installations: The EDECAD project. Drying echnology, 22:6, pp. 1403-1461.
33. Verdurmen, R.E.M., van Houwelingen, G., Gunsing, M., Verschueren, M. and Straatsma, J. (2006) Agglomeration in spray drying installations (the EDECAD project): Stickiness measurements and simulation results. Drying Technology, 24:6, pp. 721-726.
34. Masuda, H. and Matsusaka, S. (1997) Powder Technology Handbook, pp. 143-154. Marcel Dekker, New York
35. (1990) Prevention of Fires and Explosions in Dryers-A User Guide, Institution of Chemical Engineers, Warwickshire, England
36. Kieviet, F.G. (1997) Modeling Quality in Spray Drying, p. 72. Eindhoven, The Netherlands
37. Chen, X.D., Lake, R. and Jebson, S. (1993) Study of milk powder deposition on a large industrial dryer. Trans. I. Chem. E., 71, pp. 180-186.
38. Masters, K. (1996) Proceedings of the 10th International Drying Symposium (IDS '96), Drying '96, pp. 52-60. Lodz Technical University, Krakow, Poland
39. Bhandari, B.R., Datta, N. and Howes, T. (1997) Problems associated with spray drying of sugar-rich foods. Drying Technology, 15:2, pp. 671-684.
40. Papadakis, S.E. and Bahu, R.E. (1992) The sticky issues of drying. Drying Technology, 10:4, pp. 817-837.
41. Ozmen, L. and Langrish, T.A.G. (2002) Comparison of glass transition temperature and stick-point temperature for skim milk powder. Drying Technology, 20:6, pp. 1177-1192.
42. Ozmen, L. and Langrish, T.A.G. (2003) An experimental investigation of the wall deposition of milk powder in a pilot-scale spray dryer. Drying Technology, 21:7, pp. 1253-1272.
43. Murti, R.A., Paterson, A.H.J., Pearce, D. and Bronlund, J.E. (2006) Proceedings of the 6th International Drying Symposium (IDS '88), Auckland, New Zealand
44. Langrish, T.A.G., Chan, W.C. and Kota, K. (2007) Comparison of maltodextrin and skim milk deposition rates in a pilot-scale spray dryer. Powder Technology
45. Kim, E., Chen, X.D. and Pearce, D. (2003) On the mechanisms of surface formation and the surface compositions of industrial milk powders. Drying Technology, 21:2, pp. 265-278.
46. Nijdam, J.J. and Langrish, T.A.G. (2006) The effect of surface composition on the functional properties of milk powders. Journal of Food Engineering, 77:4, pp. 919-925.
47. Adhikari, B., Howes, T., Shrestha, A.K. and Bhandari, B.R. (2006) Effect of surface tension and viscosity on the surface stickiness of carbohydrate and protein solutions. Journal of Food Engineering, 79:4, pp. 1136-1143.
48. Ozmen, L. and Langrish, T.A.G. (2005) An experimental investigation into wall deposition of milk powder in spray dryers. Developments in Chemical Engineering and Minerals Processing, 13:12, pp. 91-108.
49. Kerkhof, P.J.A.M. (1994) The role of theoretical and mathematical modelling in scale-up. Drying Technology, 12:1, pp. 1-46.
50. Coumans, W.J., Kerkhof, P.J.A.M. and Bruin, S. (1994) Theoretical and practical aspects of aroma retention in spray drying and freeze drying. Drying Technology, 12:1, pp. 99-149.
51. Rulkens, W.H. and Thijssen, H.A.C. (1969) Numerical solution of diffusion equations with strongly variable diffusion coefficients. Calculation of flavour loss in drying food liquids. Transactions of the Institution of Chemical Engineers, 47:9, pp. T292-T298.
52. Langrish, T.A.G. and Kockel, T.K. (2001) The implementation of a characteristic drying curve for milk powder using a computational fluid dynamics simulation. Chemical Engineering Journal, 84:1, pp. 69-74.
53. Langrish, T.A.G., Marquez, N. and Kota, K. (2006) An investigation and quantitative assessment of particle shape in milk powders from a laboratory-scale dryer. Drying Technology, 24:12, pp. 1619-1630.
54. White, G.W. and Cakebread, S.H. (1966) The glassy state in certain sugar containing food products. Journal of Food Technology, 1:1, pp. 73-82.
55. Williams, M.L., Landel, R.F. and Ferry, J.D. (1955) The temperature dependence of relaxation mechanisms in amorphous polymers and other glass-forming liquids. Journal of the American Chemical Society, 77:14, pp. 3701-3707.
56. Roberts, C.J. and Debenedetti, P. (2002) Engineering pharmaceutical stability with amorphous solids. AIChE Journal, 48:6, pp. 1140-1144.
57. Palzer, S. (2005) The effect of glass transition on the desired and undesired agglomeration of amorphous food powders. Chemical Engineering Science, 60:14, pp. 3959-3968.
58. Chan, H.-K. and Chew, N.Y.K. (2003) Novel alternative methods for delivery of drugs for the treatment of asthma. Advanced Drug Delivery Review, 55:7, pp. 793-805.
59. Chidavaenzi, O.C., Buckton, G. and Koosha, F. (2001) The effect of co-spray drying with polyethylene glycol 4000 on the crystallinity and physical form of lactose. International Journal of Pharmaceutics, 216:1, pp. 43-49.
60. Price, R. and Young, P.M. (2004) Visualisation of the crystallisation of lactose from the amorphous state. Journal of Pharmaceutical Sciences, 93:1, pp. 155-164.
61. Lloyd, R., Chen, X.D. and Hargreaves, J.B. (1996) Glass transition and caking of spray-dried lactose. International Journal of Food Science and Technology, 31:4, pp. 305-311.
62. Vidgren, M.T., Vidgren, P.A. and Paronen, T.P. (1987) Comparison of physical and inhalation properties of spray-dried and mechanically micronized disodium cromoglycate. International Journal of Phamacy, 35:1, pp. 139-144.
63. Chawla, A., Taylor, K.M.G., Taylor, J.M. and Johnson, M.C.R. (1994) Production of spray dried salbutamol sulfate for use in dry powder aerosol fomulation. International Journal of Phamacy, 108:3, pp. 233-240.
64. Chickering III, D.E., Keegan, M.J., Randall, G., Bernstein, H. and Straub, J. Spray Drying Method
65. Mcleod, J.S. and Paterson, A.H.J. (2005) A preliminary study into the role of sliding contact in the adhesion of alpha lactose monohydrate to a conveying line wall. Proceedings of Chemeca 2005
66. Willart, J.F., De Gusseme, A., Hemon, S., Odou, G., Danede, F. and Descamps, M. (2001) Direct crystal to glass transformation of trehalose induced by ball milling. Solid State Communications, 119:8, pp. 501-505.
67. Bhandari, B.R. and Howes, T. (1999) Implication of glass transition for the drying and stability of dried foods. Journal of Food Engineering, 40:1, pp. 71-79.
68. Wang, S. (2006)The University of Sydney
69. Briggner, L.-E., Bystrom, K., Jakupovic, E., Trofast, E. and Trofast, J. Paramaceutical Formulation
70. Kussendrager, K.D. and Ellison, M.J.H. Carrier Material for Dry Powder Inhalation
71. Ward, G. and Dwivedi, S. Physically Stabilized Dry Powder Formulation