Estrogen replacement in menopausal women: Recent and current prospective studies, the WHI and the KEEPS

Gender Medicine

Volumn 3, Issue 4, 2006, Pages 254-269

  Harman, S Mitchell ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED ESTROGEN; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; ESTRADIOL; ESTROGEN; ESTROGEN DERIVATIVE; GESTAGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEDROXYPROGESTERONE ACETATE; PLACEBO; PROGESTERONE; PROGESTERONE DERIVATIVE; SIMVASTATIN;

AGE; ALZHEIMER DISEASE; ANGIOCARDIOGRAPHY; ARTICLE; BREAST CANCER; CANCER RISK; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CEREBROVASCULAR ACCIDENT; CHOLELITHIASIS; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CORONARY ARTERY DISEASE; DIET THERAPY; DRUG ABSORPTION; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; DRUG TRANSPORT; EARLY INTERVENTION; ENDOMETRIUM CANCER; ESTROGEN DEFICIENCY; ESTROGEN THERAPY; EXERCISE; FEMALE; FOLLOW UP; GALLBLADDER DISEASE; GALLSTONE; HEART PROTECTION; HOT FLUSH; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; LOW DRUG DOSE; MENOPAUSAL SYNDROME; MONOTHERAPY; MORTALITY; NONHUMAN; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; POSTMENOPAUSE; PRACTICE GUIDELINE; PRESCRIPTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; RISK FACTOR; RISK REDUCTION; THROMBOEMBOLISM; TRANSLUMINAL CORONARY ANGIOPLASTY; VAGINA ATROPHY; VASCULAR DISEASE; VENOUS THROMBOEMBOLISM;

AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARDIOVASCULAR DISEASES; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HOT FLASHES; HUMANS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PROGESTINS; PROSPECTIVE STUDIES; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIALS; RISK ASSESSMENT; WOMEN'S HEALTH;

EID: 34250355937     PISSN: 15508579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1550-8579(06)80214-7     Document Type: Article

References (41)

1. Available at: [eh][ir]http://www.cdc.gov/nchs/datawh/statab/unpubd/mortabs/gmwkhi.htm. National Center for Health Statistics. Mortality tables. GMWKHI: Deaths from each cause, by 5-year age groups. Hispanic origin, race for nonHispanic population, and sex: United States (1999) 2002-2003
2. Available at: [eh][ir]http://seer.cancer. gov/csr/1975 2000/. National Cancer Institute. Surveillance epidemiology and end results. SEER cancer statistics review (1975-2000)
3. Eberhardt M.S., Ingram D.D., Makuc D.M., et al. Health, United States, 2001: With Urban and Rural Chartbook (2001), National Center for Health Statistics, Hyattsville, Md 189
4. Eberhardt M.S., Ingram D.D., Makuc D.M., et al. Health, United States, 2001: With Urban and Rural Chartbook (2001), National Center for Health Statistics, Hyattsville, Md 192
5. In: Ries L.A., Eisner M.P., Kosary C.L., et al. (Eds). SEER Cancer Statistics Review, 1973-1998 (2001), National Cancer Institute, Bethesda, Md
6. Hodis H.N., Mack W.J., and Lobo R. Postmenopausal hormone replacement therapy as antiatherosclerotic therapy. Curr Atheroscler Rep 4 (2002) 52-58
7. Darling G.M., Johns J.A., McCloud P.I., and Davis S.R. Estrogen and progestin compared with simvastatin for hypercholesterolemia in postmenopausal women. N Engl J Med 337 (1997) 595-601
8. Wakatsuki A., Okatani Y., Ikenoue N., and Fukaya T. Effect of medroxyprogesterone acetate on endotheliumdependent vasodilation in postmenopausal women receiving estrogen. Circulation 104 (2001) 1773-1778
9. Stampfer M.J., Willett W.C., Colditz G.A., et al. A prospective study of postmenopausal estrogen therapy and coronary heart disease. N Engl J Med 313 (1985) 1044-1049
10. Wilson P.W., Garrison R.J., and Castelli W.P. Postmenopausal estrogen use, cigarette smoking, and cardiovascular morbidity in women over 50. The Framingham Study. N Engl J Med 313 (1985) 1038-1043
11. Bush T.L., Barrett-Connor E., Cowan L.D., et al. Cardiovascular mortality and noncontraceptive use of estrogen in women: Results from the Lipid Research Clinics Program Follow-up Study. Circulation 75 (1987) 1102-1109
12. Petitti D.B., Perlman J.A., and Sidney S. Noncontraceptive estrogens and mortality: Long-term followup of women in the Walnut Creek Study. Obstet Gynecol 70 (1987) 289-293
13. Boysen G., Nyboe J., Appleyard M., et al. Stroke incidence and risk factors for stroke in Copenhagen, Denmark. Stroke 19 (1988) 1345-1353
14. Criqui M.H., Suarez L., Barrett-Connor E., et al. Postmenopausal estrogen use and mortality. Results from a prospective study in a defined, homogeneous community. Am J Epidemiol 128 (1988) 606-614
15. Henderson B.E., Paganini-Hill A., and R.RK.E.r.t.a.p.f.a.m.i.[p.c.a.i.A.j.O.Gynecol.1988;159:1574]. Am j Obstet Gynecol 159 (1988) 312-317
16. van der Giezen A.M., Schopman-Geurts van Kessel J.G., Schouten E.G., et al. Systolic blood pressure and cardiovascular mortality among 13,740 Dutch women. Prev Med 19 (1990) 456-465
17. Wolf P.H., Madans J.H., Finucane F.F., et al. Reduction of cardiovascular disease-related mortality among postmenopausal women who use hormones: Evidence from a national cohort. Am J Obstet Gynecol 164 (1991) 489-494
18. Falkeborn M., Persson I., Adami H.O., et al. The risk of acute myocardial infarction after oestrogen and oestrogen-progestogen replacement. Br J Obstet Gynaecol 99 (1992) 821-828
19. Psaty B.M., Heckbert S.R., Atkins D., et al. The risk of myocardial infarction associated with the combined use of estrogens and progestins in post menopausal women. Arch Intern Med 154 (1994) 1333-1339
20. Folsom A.R., Mink P.J., Sellers T.A., et al. Hormonal replacement therapy and morbidity and mortality in a prospective study of postmenopausal women. Am J Public Health 85 (1995) 1128-1132
21. Grodstein F., Stampfer M.J., Manson J.E., et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease [published correction appears in N Engl I Med. 1996;335:1406]. N Engl J Med 335 (1996) 453-461
22. Colditz G.A., Hankinson S.E., Hunter D.J., et al. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med. 332 (1995) 1589-1593
23. Schairer C., Lubin J., Troisi R., et al. Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk [published correc tion appears in LAMA. 2000;284:2597]. JAMA 283 (2000) 485-491
24. Rossouw J.E., Anderson G.L., Prentice R.L., et al., for the Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estro gen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 (2002) 321-333
25. Silverstein M.D., Heit J.A., Mohr D.N., et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism: A 25-year population-based study. Arch Intern Med 158 (1998) 585-593
26. Grodstein F., Manson J.E., Colditz G.A., et al. A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med 133 (2000) 933-941
27. Grodstein F., Stampfer M.J., Colditz G.A., et al. Postmenopausal hormone therapy and mortality. N Engl J Med 336 (1997) 1769-1775
28. Hulley S., Grady D., Bush T., et al., for the Heart and Estrogen/progestin Replacement Study (HERS) Research Group. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 280 (1998) 605-613
29. Available at: [eh][ir]http://www. fda.gov/oc/factsheets/WHI.html. US Food and Drug Administration, and FDA Fact Sheet. FDA approves new labeling and provides new advice to postmenopausal women who use or who are considering using estrogen and estrogen with progestin (January 8, 2003)
30. Scarabin P.Y., Oger E., Plu-Bureau G., and EStrogen and THromboEmbolism Risk Study Group. Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk. Lancet 362 (2003) 428-432
31. Pai J.K., Pischon T., Ma J., et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 351 (2004) 2599-2610
32. Hu P., Greendale G.A., Palla S.L., et al. The effects of hormone therapy on the markers of inflammation and endothelial function and plasma matrix metalloproteinase-9 level in postmenopausal women: The postmenopausal estrogen progestin intervention (PEPI) trial. Atherosclerosis 185 (2006) 347-352
33. Anderson G.L., Limacher M., Assaf A.R., et al., Women's Health Initiative Steering Committee. Effects of conjugated equine estrogen in post menopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial. JAMA 291 (2004) 1701-1712
34. Mendelsohn M.E., and Karas R.H. Molecular and cellular basis of cardiovascular gender differences. Science 308 (2005) 1583-1587
35. Raggi P., Callister T.Q., Cooil B., et al. Identification of patients at increased risk of first unheralded acute myocardial infarction by electron-beam computed tomography. Circulation 101 (2000) 850-855
36. Clarkson T.B., Anthony M.S., and Jerome C.P. Lack of effect of raloxifene on coronary artery atherosclerosis of postmenopausal monkeys. J Clin Endocrinol Metab 83 (1998) 721-726
37. Adams M.R., Register T.C., Golden D.L., et al. Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coro nary artery atherosclerosis. Arterioscler Thromb Vasc Biol 17 (1997) 217-221
38. Williams J.K., Anthony M.S., Honore E.K., et al. Regression of atherosclerosis in female monkeys. Arterioscler Thromb Vasc Biol 15 (1995) 827-836
39. Manson J.E., Hsia J., Johnson K.C., et al., Women's Health Initiative Investigators. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 349 (2003) 523-534
40. [published correction appears in Arch Intern Med. 2006;166: 759]. Hsia J., Langer R.D., Manson J.E., et al., Women's Health Initiative Investigators. Conjugated equine estrogens and coronary heart dis ease: The Women's Health Initiative. Arch Intern Med 166 (2006) 357-365
41. Kronos Longevity Research Institute. The Kronos Early Estrogen Prevention Study (KEEPS). Available at: http://www.keepsstudy.org/.