Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 29, Issue 3, 2007, Pages 191-194

  Stepanović Petrović, Radica M ^a,d   Tomic M A ^a   Vuckovic S M ^b   Ugresic N D ^b   Prostran, M S ^b   Boskovic B ^c  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c UNIVERSITY OF DEFENCE   (Serbia)

^d School of Pharmacy   (Yugoslavia)

Author keywords

Carbamazepine; Inflammatory hyperalgesia; Naloxone; Opioid receptors; Oxcarbazepine

Indexed keywords

CARBAMAZEPINE; NALOXONE; OPIATE RECEPTOR; OXCARBAZEPINE;

ANALYSIS OF VARIANCE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; NONHUMAN; RAT;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTICONVULSANTS; CARBAMAZEPINE; CONCANAVALIN A; HYPERALGESIA; MALE; NALOXONE; NARCOTIC ANTAGONISTS; PAIN; RATS; RATS, WISTAR; RECEPTORS, OPIOID;

EID: 34250353535     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2007.29.3.1075352     Document Type: Article

References (15)

1. Rang, H.P., Dale, M.M., Ritter, J.M., Moore, P.K. Antiepileptic drugs. In: Pharmacology, 5th ed. Churchill Livingston: Edinburgh 2003, 550-61.
2. Beydoun, A., Kutluay, E. Oxcarbazepine. Expert Opin Pharmacother 2002, 3: 59-71.
3. Tomić, M.A., Vučković, S.M., Stepanović- Petrović, R.M., Ugrešić, N., Prostran, M.S., Bošković, B. The anti-hyperalgesic effects of carbamazepine and oxcarbazepine are attenuated by treatment with adenosine receptor antagonists. Pain 2004, 111: 253-60.
4. 1 receptors. Pharmazie 2006, 61: 566-68.
5. Vučković, S.M., Tomić, M.A., Stepanović- Petrović, R.M., Ugrešić, N., Prostran, M.S., Bošković, B. Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat. A new target for carbamazepine? J Pharmacol Sci 2006, 100: 310-14.
6. Vučković, S.M., Tomić, M.A., Stepanović- Petrović, R.M., Ugrešić, N., Prostran, M.S., Bošković, B. The effects of alpha(2)-adrenoceptor agents on anti-hyperalgesic effects of carbamaze- pine and oxcarbazepine in a rat model of inflammatory pain. Pain 2006; 125: 10-9.
7. Porter, R.J., Meldrum, B.S. Antiseizure drugs. In: Basic & Clinical Pharmacology, 9th ed. Katzung (Ed.). Lange Medical Books/McGraw-Hill: New York 2004, 379-400.
8. Ambrosio, A.F., Soares-da-Silva, P., Carvalho, CM., Carvalho, A.P. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem Res 2002, 27: 121-30.
9. Foong, F.W., Satoh, M. Neurotransmitter-blocking agents influence antinociceptive effects of carbamazepine, baclofen, pentazocine and morphine on bradykinin-induced trigeminal pain. Neuropharmacology 1984, 23: 633-6.
10. Mashimoto, S., Ushijima, I., Suetsugi, M., Akimoto, T., Watanabe, K., Yamada, M. Stress-dependent antinociceptive effects of carbamazepine: a study in stressed and nonstressed rats. Prog Neuropsychopharmacol Biol Psychiatry 1998, 22: 159-68.
11. Sawynok, J. Topical and peripherally acting analgesics. Pharmacol Rev 2003, 55: 1-20.
12. Parsons, C.G., Herz, A. Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress. J Pharmacol Exp Ther 1990, 255: 795-802.
13. Wang, P.F., Zhang, Y.Q., Qiu, Z.B., Zhao, Z.Q. Antinociceptive effects of meptazinol and its isomers on carrageenan-induced thermal hyperalgesia in rats. Sheng Li Xue Bao 2004, 56: 295-300.
14. Le Bars D., Gozariu M., Cadden S.W. Animal models of nociception. Pharmacol Rev 2001, 53: 597-652.
15. Kiguchi, S., Imamura, T., Ichikawa, K., Kojima, M., Shibata, N. Antinociceptive effect of oxcarbazepine (KIN-493/OCBZ) in diabetic animals and its pharmacological properties. Pharmacologist 2002, 44: A54.