Oxidative stress alters the integrity of cell-free mRNA fragments associated with placenta-derived syncytiotrophoblast microparticles

Fetal Diagnosis and Therapy

Volumn 22, Issue 4, 2007, Pages 313-317

  Rusterholz, Corinne ^a   Holzgreve, Wolfgang ^a   Hahn, Sinuhe ^a  

^a UNIVERSITY WOMEN S HOSPITAL   (Switzerland)

Author keywords

Cell free fetal RNA; Oxidative stress; Placenta derived syncytiotrophoblast microparticles

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; HUMAN CELL CULTURE; HUMAN TISSUE; IN VITRO STUDY; OXIDATIVE STRESS; PARTICLE SIZE; PLACENTA; PREECLAMPSIA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNCYTIOTROPHOBLAST;

BIOLOGICAL MARKERS; CELL HYPOXIA; FEMALE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS; RNA STABILITY; RNA, MESSENGER; TROPHOBLASTS;

EID: 34250332277     PISSN: 10153837     EISSN: None     Source Type: Journal    
DOI: 10.1159/000100798     Document Type: Article

References (22)

1. Poon LL, Leung TN, Lau TK, Lo YM: Presence of fetal RNA in maternal plasma. Clin Chem 2000;46:1832-1834.
2. Oudejans CB, Go AT, Visser A, Mulders MA, Westerman BA, Blankenstein MA, van Vugt JM: Detection of chromosome 21-encoded mRNA of placental origin in maternal plasma. Clin Chem 2003;49:1445-1449.
3. Ng EK, Tsui NB, Lau TK, Leung TN, Chiu RW, Panesar NS, Lit LC, Chan KW, Lo YM: mRNA of placental origin is readily detectable in maternal plasma. Proc Natl Acad Sci USA 2003;100:4748-4753.
4. Wong BC, Chiu RW, Tsui NB, Chan KC, Chan LW, Lau TK, Leung TN, Lo YM: Circulating placental RNA in maternal plasma is associated with a preponderance of 5′ mRNA fragments: implications for noninvasive prenatal diagnosis and monitoring. Clin Chem 2005;51:1786-1795.
5. Huppertz B, Kingdom JC: Apoptosis in the trophoblast - role of apoptosis in placental morphogenesis. J Soc Gynecol Investig 2004;11:353-362.
6. Johansen M, Redman CW, Wilkins T, Sargent IL: Trophoblast deportation in human pregnancy - its relevance for pre-eclampsia. Placenta 1999;20:531-539.
7. Knight M, Redman CW, Linton EA, Sargent IL: Shedding of syncytiotrophoblast microvilli into the maternal circulation in preeclamptic pregnancies. Br J Obstet Gynaecol 1998;105:632-640.
8. Smarason AK, Sargent IL, Starkey PM, Redman CW: The effect of placental syncytiotrophoblast microvillous membranes from normal and pre-eclamptic women on the growth of endothelial cells in vitro. Br J Obstet Gynaecol 1993;100:943-949.
9. Gupta AK, Rusterholz C, Huppertz B, Malek A, Schneider H, Holzgreve W, Hahn S: A comparative study of the effect of three different syncytiotrophoblast micro-particle preparations on endothelial cells. Placenta 2005;26:59-66.
10. Gupta AK, Holzgreve W, Huppertz B, Malek A, Schneider H, Hahn S: Detection of fetal DNA and RNA in placenta-derived syncytiotrophoblast microparticles generated in vitro. Clin Chem 2004;50:2187-2190.
11. Burton GJ, Jauniaux E: Placental oxidative stress: from miscarriage to preeclampsia. J Soc Gynecol Investig 2004;11:342-352.
12. Rusterholz C, Gupta AK, Huppertz B, Holzgreve W, Hahn S: Soluble factors released by placental villous tissue: interleukin-1 is a potential mediator of endothelial dysfunction. Am J Obstet Gynecol 2005;192:618-624.
13. Huppertz B, Kingdom J, Caniggia I, Desoye G, Black S, Korr H, Kaufmann P: Hypoxia favours necrotic vs. apoptotic shedding of placental syncytiotrophoblast into the maternal circulation. Placenta 2003;24:181-190.
14. Hung TH, Skepper JN, Charnock-Jones DS, Burton GJ: Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res 2002;90:1274-1281.
15. Zhong XY, Holzgreve W, Hoesli I, Hahn S: Circulatory corticotropin- releasing hormone mRNA concentrations are increased in women with preterm delivery but not in those who respond to tocolytic treatment. Clin Chem 2005;51:635-636.
16. Ng EK, Leung TN, Tsui NB, Lau TK, Panesar NS, Chiu RW, Lo YM: The concentration of circulating corticotropin-releasing hormone mRNA in maternal plasma is increased in preeclampsia. Clin Chem 2003;49:727-731.
17. Zhong XY, Gebhardt S, Hillermann R, Tofa KC, Holzgreve W, Hahn S: Parallel assessment of circulatory fetal DNA and corticotropin-releasing hormone mRNA in early-and late-onset preeclampsia. Clin Chem 2005;51:1730-1733.
18. Ng EK, El Sheikhah A, Chiu RW, Chan KC, Hogg M, Bindra R, Leung TN, Lau TK, Nicolaides KH, Lo YM: Evaluation of human chorionic gonadotropin beta-subunit mRNA concentrations in maternal serum in aneuploid pregnancies: a feasibility study. Clin Chem 2004;50:1055-1057.
19. Wang Y, Walsh SW: Placental mitochondria as a source of oxidative stress in pre-eclampsia. Placenta 1998;19:581-586.
20. Hahn S, Holzgreve W: Fetal cells and cell-free fetal DNA in maternal blood: new insights into pre-eclampsia. Hum Reprod Update 2002;8:501-508.
21. Redman CW, Sargent IL: Placental debris, oxidative stress and pre-eclampsia. Placenta 2000;21:597-602.
22. Ng EK, Tsui NB, Lam NY, Chiu RW, Yu SC, Wong SC, Lo ES, Rainer TH, Johnson PJ, Lo YM: Presence of filterable and nonfilterable mRNA in the plasma of cancer patients and healthy individuals. Clin Chem 2002;48:1212-1217.