Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?

Cancer Epidemiology Biomarkers and Prevention

Volumn 16, Issue 5, 2007, Pages 892-894

  Daley, Denise ^a,d,e   Morgan, Wendi ^a   Lewis, Susan ^a   Willis, Joseph ^a   Elston, Robert C ^a,b   Markowitz, Sanford D ^a,b,c   Wiesner, Georgia L ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1; TUMOR MARKER; PROTEIN SERINE THREONINE KINASE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CANCER RISK; CHROMOSOME 9Q; COLORECTAL TUMOR; CONTROLLED STUDY; FAMILIAL CANCER; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; PRIORITY JOURNAL; CHROMOSOME 9; FAMILY; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MALE; REGRESSION ANALYSIS;

ALLELES; CHROMOSOMES, HUMAN, PAIR 9; COLORECTAL NEOPLASMS; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REGRESSION ANALYSIS;

EID: 34250330252     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-06-0965     Document Type: Article

References (15)

1. Pasche B, Luo Y, Rao PH, et al. Type I transforming growth factor β receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. Cancer Res 1998;58:2727-32.
2. Pasche B, Kolachana P, Nafa K, et al. TβR-I (6A) is a candidate tumor susceptibility allele. Cancer Res 1999;59:5678-82.
3. Kaklamani VG, Hou N, Bian Y, et al. TGFBR1*6A and cancer risk: a meta-analysis of seven case-control studies. J Clin Oncol 2003;21:3236-43.
4. Pasche B, Kaklamani V, Hou N, et al. TGFBR1*6A and cancer: a meta-analysis of 12 case-control studies. J Clin Oncol 2004;22:756-8.
5. Bian Y, Caldes T, Wijnen J, et al. TGFBR1*6A may contribute to hereditary colorectal cancer. J Clin Oncol 2005;23:3074-8.
6. Wiesner GL, Daley D, Lewis S, et al. A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci U S A 2003;100:12961-5.
7. Skoglund J, Djureinovic T, Zhou XL, et al. Linkage analysis in a large Swedish family supports the presence of a susceptibility locus for adenoma and colorectal cancer on chromosome 9q22.32-31.1. J Med Genet 2006;43:e7.
8. Kemp ZE, Carvajal-Carmona LG, Barclay E, et al. Evidence of linkage to chromosome 9q22.33 in colorectal cancer kindreds from the United Kingdom. Cancer Res 2006;66:5003-6.
9. Haseman JK, Elston RC. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 1972;2:3-19.
10. Cardon LR. A sib-pair regression model of linkage disequilibrium for quantitative traits. Hum Hered 2000;50:350-8.
11. Fulker DW, Cherny SS, Sham PC, Hewitt JK. Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 1999;64:259-67.
12. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-16.
13. Spielman RS, Ewens WJ. A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am J Hum Genet 1998;62:450-8.
14. Li H, Fan J. A general test of association for complex diseases with variable age of onset. Genet Epidemiol 2000;19 Suppl 1:S43-9.
15. Blackwelder WC, Elston RC. A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol 1985;2:85-97.