메뉴 건너뛰기




Volumn 8, Issue 6, 2007, Pages 396-398

A randomized phase II study of sorafenib/gemcitabine or sorafenih/erlotinib for advanced non-small-cell lung cancer in elderly patients or patients with a performance status of 2: Treatment rationale and protocol dynamics

Author keywords

Chemotherapy; Epidermal growth factor receptor; Vascular endothelial growth factor receptor

Indexed keywords

BIOLOGICAL MARKER; ERLOTINIB; GEMCITABINE; SORAFENIB;

EID: 34250324694     PISSN: 15257304     EISSN: None     Source Type: Journal    
DOI: 10.3816/CLC.2007.n.023     Document Type: Article
Times cited : (26)

References (17)
  • 2
    • 1342268525 scopus 로고    scopus 로고
    • American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: Update 2003
    • Pfister DG, Johnson DH, Azzoli CG, et al. American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol 2004; 22:330-353.
    • (2004) J Clin Oncol , vol.22 , pp. 330-353
    • Pfister, D.G.1    Johnson, D.H.2    Azzoli, C.G.3
  • 3
    • 11144357752 scopus 로고    scopus 로고
    • Treatment of advanced non small cell lung cancer patients with ECOG performance status 2: Results of an European Experts Panel
    • Gridelli C, Ardizzoni A, Le Chevalier T, et al. Treatment of advanced non small cell lung cancer patients with ECOG performance status 2: results of an European Experts Panel. Ann Oncol 2004; 15:419-426.
    • (2004) Ann Oncol , vol.15 , pp. 419-426
    • Gridelli, C.1    Ardizzoni, A.2    Le Chevalier, T.3
  • 5
    • 0037420202 scopus 로고    scopus 로고
    • Chemotherapy for elderly parients with advanced non-small-cell lung cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial
    • Gridelli C, Perrone F, Gallo C, et al. Chemotherapy for elderly parients with advanced non-small-cell lung cancer: the Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J Natl Cancer Inst 2003; 95:362-372.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 362-372
    • Gridelli, C.1    Perrone, F.2    Gallo, C.3
  • 6
    • 0038662715 scopus 로고    scopus 로고
    • Participation of patients 65 years of age or older in cancer clinical trials
    • Lewis JH, Kilgore ML, Goldman DP, et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol 2003; 21:1383-1389.
    • (2003) J Clin Oncol , vol.21 , pp. 1383-1389
    • Lewis, J.H.1    Kilgore, M.L.2    Goldman, D.P.3
  • 7
    • 0033619959 scopus 로고    scopus 로고
    • Underrepresentation of patients 65 years of age or older in cancer-treatment trials
    • Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999; 341:2061-2067.
    • (1999) N Engl J Med , vol.341 , pp. 2061-2067
    • Hutchins, L.F.1    Unger, J.M.2    Crowley, J.J.3
  • 8
    • 0006453669 scopus 로고    scopus 로고
    • Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer
    • Elderly Lung Cancer Vinorelbine Italian Study (ELVIS) group
    • Elderly Lung Cancer Vinorelbine Italian Study (ELVIS) group. Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 1999; 91:66-72.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 66-72
  • 9
    • 21144436938 scopus 로고    scopus 로고
    • Treatment of advanced non small cell lung cancer in the elderly: Results of an international expert panel
    • Gridelli C, Aapro M, Ardizzoni A, et al. Treatment of advanced non small cell lung cancer in the elderly: results of an international expert panel. J Clin Oncol 2005; 23:3125-3137.
    • (2005) J Clin Oncol , vol.23 , pp. 3125-3137
    • Gridelli, C.1    Aapro, M.2    Ardizzoni, A.3
  • 10
    • 33947504732 scopus 로고    scopus 로고
    • Phase II clinical trial of chemotherapy-naive patients > 70 years of age treated with erlotinib for advanced non-small-cell lung cancer
    • Jackman DM, Yeap BY, Lindeman NI, et al. Phase II clinical trial of chemotherapy-naive patients > 70 years of age treated with erlotinib for advanced non-small-cell lung cancer. J Clin Oncol 2007; 25:760-766.
    • (2007) J Clin Oncol , vol.25 , pp. 760-766
    • Jackman, D.M.1    Yeap, B.Y.2    Lindeman, N.I.3
  • 11
    • 85030513531 scopus 로고    scopus 로고
    • Jackman DM, Yeap B, Lucca J, et al. Phase II trial of erlotinib in elderly patients (age > 70) with previously untreated advanced non-small cell lung cancer (NSCLC): an analysis quality of life and symptom response. J Clin Oncol 2006; 24(18 suppl):406s (Absrracr #7168).
    • Jackman DM, Yeap B, Lucca J, et al. Phase II trial of erlotinib in elderly patients (age > 70) with previously untreated advanced non-small cell lung cancer (NSCLC): an analysis quality of life and symptom response. J Clin Oncol 2006; 24(18 suppl):406s (Absrracr #7168).
  • 12
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004; 64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 13
    • 33845371047 scopus 로고    scopus 로고
    • Sorafenib is efficacious and tolerated in combination with cytotoxic or cytostatic agents in preclinical models of human non-small cell lung carcinoma
    • Carter CA, Chen C, Brink C, et al. Sorafenib is efficacious and tolerated in combination with cytotoxic or cytostatic agents in preclinical models of human non-small cell lung carcinoma. Cancer Chemother Pharmacol 2007; 59:183-195.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 183-195
    • Carter, C.A.1    Chen, C.2    Brink, C.3
  • 14
    • 33748913369 scopus 로고    scopus 로고
    • Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma
    • 18 suppl):673s Abstract #7002
    • Gatzemeier U, Blumenschein G, Fosella F. Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma. J Clin Oncol 2006; 24(18 suppl):673s (Abstract #7002).
    • (2006) J Clin Oncol , pp. 24
    • Gatzemeier, U.1    Blumenschein, G.2    Fosella, F.3
  • 15
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear cell renal-cell carcinoma. N Engl J Med 2007; 356:125-134.
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 16
    • 33847025077 scopus 로고    scopus 로고
    • Dual inhibition of the MAPK pathway by combination targeted therapy: A phase I trial of sorafenib (SOR) and erlotinib (ERL) in advanced solid tumors
    • 167
    • Duran I, Hotte S, Hirte H, et al. Dual inhibition of the MAPK pathway by combination targeted therapy: a phase I trial of sorafenib (SOR) and erlotinib (ERL) in advanced solid tumors. Eur J Cancer 2006; 4(suppl ???):167.
    • (2006) Eur J Cancer , vol.4 , Issue.SUPPL.
    • Duran, I.1    Hotte, S.2    Hirte, H.3
  • 17
    • 31544460436 scopus 로고    scopus 로고
    • Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer
    • Siu LL, Awada A, Takimoto CH, et al. Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin Cancer Res 2006; 12:144-151.
    • (2006) Clin Cancer Res , vol.12 , pp. 144-151
    • Siu, L.L.1    Awada, A.2    Takimoto, C.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.