Acute fatal acetaminophen overdose without liver necrosis

Journal of Forensic Sciences

Volumn 52, Issue 4, 2007, Pages 992-994

  Singer, Peter P ^a   Jones, Graham R ^a   Bannach, Bernard G ^a   Denmark, Lloyd ^b,c  

^a Office of the Chief Medical Examiner   (Canada)

^b Office of the Chief Medical Examiner   (Canada)

^c AUCKLAND CITY HOSPITAL   (New Zealand)

Author keywords

Acetaminophen; Cardiac; Centrilobular; Forensic science; Liver; Necrosis; Overdose; Paracetamol

Indexed keywords

NITROGEN; OLANZAPINE; PARACETAMOL;

ADULT; ANATOMY; ARTICLE; AUTOPSY; CASE REPORT; DRUG BLOOD LEVEL; DRUG FATALITY; DRUG LIVER LEVEL; DRUG MEGADOSE; DRUG SCREENING; DRUG TISSUE LEVEL; ELECTRON CAPTURE DETECTION; FEMALE; FEMORAL ARTERY FLOW; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; LIVER NECROSIS; MALE; MASS SPECTROMETRY; NITROGEN DETECTOR; PRIORITY JOURNAL; STOMACH; SUICIDE; ULTRAVIOLET RADIATION; VITREOUS BODY;

ACETAMINOPHEN; ADOLESCENT; ADULT; ANALGESICS, NON-NARCOTIC; FATAL OUTCOME; FEMALE; FORENSIC TOXICOLOGY; HUMANS; MALE; OVERDOSE; SUICIDE;

EID: 34250314028     PISSN: 00221198     EISSN: 15564029     Source Type: Journal    
DOI: 10.1111/j.1556-4029.2007.00482.x     Document Type: Article

References (27)

1. Roberts LJ II., Morrow JD. Analgesic-antipyretic and antiinflammatory agents and drugs. In: Hardman JG, Limbird LE, Gilman AG, editors. The pharmacological basis of therapeutics. New York: McGraw-Hill, 2001 703.
2. Prescott LF, Sansur M, Levin W, Conney AH. The comparative metabolism of phenacetin and N-acetyl-p-aminophenol in man, with particular reference to effects on the kidney. Clin Pharm Ther 1968 9: 605 14.
3. Jones GR, Pounder DJ. Site dependence of drug concentrations in postmortem blood - a case study. J Anal Tox 1987 11: 186 90.
4. Pounder DJ, Fuke C, Cox DE, Smith D, Kuroda N. Postmortem diffusion of drugs from gastric residue: an experimental study. Am J Forensic Med Pathol 1996 17 (1 1 7.
5. Corcoran GB, Mitchell JR, Vaishnav YN, Horning EC. Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine. Mol Pharmacol 1980 18 (3 536 42.
6. Dahlin DC, Nelson SD. Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen. J Med Chem 1982 25 (8 885 6.
7. Raucy JL, Lasker JM, Lieber CS, Black M. Acetaminophen activation by human liver cytochromes. P450IIE1 and P450IA2. Arch Biochem Biophys 1989 271 (2 270 83.
8. Thummel KE, Lee CA, Kunze KL, Nelson SD, Slattery JT. Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4. Biochem Pharmacol 1993 45 (8 1563 9.
9. Patten CJ, Thomas PE, Guy RL, Lee M, Gonzalez FJ, Guengerich FP, et al. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem Res Toxicol 1993 6 (4 511 8.
10. Streeter AJ, Dahlin DC, Nelson SD, Baillie TA. The covalent binding of acetaminophen to protein. Evidence for cysteine residues as major sites of arylation in vitro. Chem Biol Interact 1984 48 (3 349 66.
11. Hoffmann KJ, Streeter AJ, Axworthy DB, Baillie TA. Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins. Mol Pharmacol 1985 27 (5 566 73.
12. Hoffmann KJ, Axworthy DB, Baillie TA. Mechanistic studies on the metabolic activation of acetaminophen in vivo. Chem Res Toxicol 1990 3 (3 204 11.
13. Dietze EC, Schafer A, Omichinski JG, Nelson SD. Inactivation of glyceraldehyde-3-phosphate dehydrogenase by a reactive metabolite of acetaminophen and mass spectral characterization of an arylated active site peptide. Chem Res Toxicol 1997 10 (10 1097 103.
14. Forrest JA, Adriaenssens P, Finlayson ND, Prescott LF. Paracetamol metabolism in chronic liver disease. Eur J Clin Pharmacol 1979 5 (6 427 31.
15. Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet 1982 7 (2 93 107.
16. Baselt RC. Disposition of toxic drugs and chemicals in man. Foster City, CA: Biomedical Publications, 2004.
17. Newton JF, Bailie MB, Hook JB. Acetaminophen nephrotoxicity in the rat. Renal metabolic activation in vitro. Toxicol Appl Pharmacol 1983 70 (3 433 44.
18. Nicholls AW, Caddick S, Wilson ID, Farrant RD, Lindon JC, Nicholson JK. High resolution NMR spectroscopic studies on the metabolism and futile deacetylation of 4-hydroxyacetanilide (paracetamol) in the rat. Biochem Pharmacol 1995 49 (8 1155 64.
19. Mugford CA, Tarloff JB. The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats. Toxicol Lett 1997 93 (1 15 22.
20. Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994 270 (1 414 23.
21. Schiodt FV, Rochling FA, Casey DL, Lee WM. Acetaminophen toxicity in an urban county hospital. N Engl J Med 1997 337 (16 1112 7.
22. Armour A, Slater SD. Paracetamol cardiotoxicity. Postgrad Med J 1993 69 (807 52 4.
23. Sanerkin NG. Acute myocardial necrosis in paracetamol poisoning. Br Med J 1971 3 (772 478.
24. Will EJ, Tomkins AM. Acute myocardial necrosis in paracetamol poisoning. Br Med J 1971 4 (784 430 1.
25. Wakeel RA, Davies HT, Williams JD. Toxic myocarditis in paracetamol poisoning. Br Med J (Clin Res Ed) 1987 295 (6606 1097.
26. Flanagan RJ, Mant TG. Coma and metabolic acidosis early in severe acute paracetamol poisoning. Hum Toxicol 1986 5 (3 179 82.
27. Weston MJ, Talbot IC, Horoworth PJ, Mant AK, Capildeo R, Williams R. Frequency of arrhythmias and other cardiac abnormalities in fulminant hepatic failure. Br Heart J 1976 38 (11 1179 88.