Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: A pharmacophoric hybrid approach

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 13, 2007, Pages 3712-3715

  Yogeeswari, Perumal ^a   Sriram, Dharmarajan ^a   Sahitya, Puppala ^a   Ragavendran, Jegadeesan Vaigunda ^a   Ranganadh, Velagaleti ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

2,6 Dimethylphenyl; Ameltolide; Anticonvulsant; GABA; Pharmacophore

Indexed keywords

4 [2 (2,6 DIMETHYLAMINOPHENYLAMINO) 2 OXOETHYLAMINO] N (2,6 DIMETHYLPHENYL)BUTANAMIDE; 4 [2 (2,6 DIMETHYLPHENYLAMINO) 2 OXOETHYLAMINO]BUTANOIC ACID; 4 AMINOBUTYRIC ACID DERIVATIVE; AMELTOLIDE; AMIDE; ANTICONVULSIVE AGENT; ETHOSUXIMIDE; PHENOBARBITAL; PHENYTOIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; LIPOPHILICITY; MOUSE; NEUROTOXICITY; NONHUMAN; PHARMACOPHORE; SEIZURE;

ANIMALS; ANTICONVULSANTS; BLOOD-BRAIN BARRIER; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ETHANOL; GAMMA-AMINOBUTYRIC ACID; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MOTOR ACTIVITY; NEURONS; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 34250176233     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.032     Document Type: Article

References (15)

1. Gasior M., Carter R.B., Goldberg S.R., and Witkin J.M. J. Pharmacol. Exp. Ther. 282 (1997) 543
2. Coatsworth, J. J. NINDS monograph No. 12, 73-15, HEW publication U.S. Government Printing Office, 1971.
3. Sivilotti L., and Nistri A. Prog. Neurobiol. 36 (1991) 35
4. Meldrum B.S. Int. Rev. Neurobiol. 17 (1975) 1
5. Loscher W. In: Bartholini G., Bossi L., Lloyd K.G., and Morselli P.L. (Eds). Epilepsy and GABA Receptor Agonists: Basic and Therapeutic Research (L.E.R.S. Monograph Series) (1985), Raven Press, New York 109-119
6. Toth E., Lajhta A., Sarhan S., and Seiler N. Neurochem. Res. 8 (1983) 291
7. Yogeeswari P., Ragavendran J.V., and Sriram D. Recent Patents on CNS Drug Discov. 1 (2006) 113
8. Ragavendran J.V., Sriram D., Patel S.K., Reddy I.V., Bharathwajan N., Stables J., and Yogeeswari P. Eur. J. Med. Chem. 42 (2006) 146
9. Vamecq J., Bac P., Herrenknecht C., Maurois P., Delcourt P., and Stables J.P. J. Med. Chem. 43 (2000) 1311
10. A domestic microwave oven with the following specifications had been used: Make LG; single irradiation type Input 220 V-50 Hz, 980 W, 4.7 A; Frequency 2450 MHz.
11. Porter R.J., Cereghino J.J., Gladding G.D., Hessie B.J., Kupferberg H.J., Scoville B., and White B. Cleveland Clin. Quart. 51 (1984) 293
12. Krall R.L., Penry J.K., White B.G., Kupferbeng H.J., and Swinyard E.A. Epilepsia 19 (1978) 409
13. Belelli D., Bolger M.B., and Gee K.W. Eur. J. Pharmacol. 166 (1989) 325
14. 3: C, 63.62; H, 7.63; N, 10.60. Found: C, 63.66; H, 7.69, N, 10.62.
15. 2: C, 71.90; H, 7.95; N, 11.43. Found: C, 71.86; H, 7.91, N, 11.54.