Leprosy-specific B-cells within cellular infiltrates in active leprosy lesions

Human Pathology

Volumn 38, Issue 7, 2007, Pages 1065-1073

  Iyer, Anand M ^a   Mohanty, Keshar K ^b   van Egmond, Danielle ^a   Katoch, Kiran ^b   Faber, William R ^a   Das, Pranab K ^a   Sengupta, Utpal ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b NATIONAL JALMA INSTITUTE FOR LEPROSY AND OTHER MYCOBACTERIAL DISEASES   (India)

Author keywords

B cells; Cytokines; Leprosy lesions

Indexed keywords

ARTICLE; B LYMPHOCYTE; BORDERLINE LEPROSY; CELL DIFFERENTIATION; CELL INFILTRATION; CELL MATURATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEPROMATOUS LEPROSY; LEPROSY; MYCOBACTERIUM LEPRAE; PAUCIBACILLARY LEPROSY; PLASMA CELL; TUBERCULOID LEPROSY;

ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; ANTIGENS, CD; B-LYMPHOCYTES; CYTOKINES; HISTOCYTOCHEMISTRY; HUMANS; LEPROSY; MACROPHAGES; MYCOBACTERIUM LEPRAE; SKIN; T-LYMPHOCYTES; TISSUE CULTURE TECHNIQUES;

EID: 34250172417     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2006.12.017     Document Type: Article

References (37)

1. Ridley D.S., and Jopling W.H. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis 34 (1966) 255-273
2. Browne S.G. Self-healing leprosy: report on 2749 patients. Lepr Rev 45 (1974) 104-111
3. Godal T., Myrvang B., Froland S.S., Shao J., and Melaku G. Evidence that the mechanism of immunological tolerance ("central failure") is operative in the lack of host resistance in lepromatous leprosy. Scand J Immunol 1 (1972) 311-321
4. Smith P.G. The serodiagnosis of leprosy. Lepr Rev 63 (1992) 97-100
5. Moet F.J., Meima A., Oskam L., and Richardus J.H. Risk factors for the development of clinical leprosy among contacts, and their relevance for targeted interventions. Lepr Rev 75 (2004) 310-326
6. Bjorvatn B., Barnetson R.S., Kronvall G., Zubler R.H., and Lambert P.H. Immune complexes and complement hypercatabolism in patients with leprosy. Clin Exp Immunol 26 (1976) 388-396
7. Abulafia J., and Vignale R.A. Leprosy: accessory immune system as effector of infectious, metabolic, and immunologic reactions. Int J Dermatol 40 (2001) 673-687
8. Sehgal V.N., Aggarwal A., Srivastava G., Sharma N., and Sharma S. Evolution of histoid leprosy (de novo) in lepromatous (multibacillary) leprosy. Int J Dermatol 44 (2005) 576-578
9. Desikan K.V., Mukherjee A., Ramu G., and Tiwari V.D. Sequential histological study of lepromin reaction. Int J Lepr Other Mycobact Dis 51 (1983) 473-480
10. Burgess P.J., Fine P.E., Ponnighaus J.M., and Draper C. Serological tests in leprosy. The sensitivity, specificity and predictive value of ELISA tests based on phenolic glycolipid antigens, and the implications for their use in epidemiological studies. Epidemiol Infect 101 (1988) 159-171
11. Lai A., Fat R.F.M., Chan Pin Jin J., van Furth R., and Harboe M. In vitro synthesis of anti-mycobacterial antibodies in biopsies from skin lesions of leprosy patients. Infect Immun 27 (1980) 297-301
12. Lai A., Fat R.F.M., Harboe M., Chan Pin Jin J.C., Diesselhoff-den Dulk M.M., and van Furth R. In vitro synthesis of antimycobacterial antibodies with different specificities in various tissues of leprosy patients. Int J Lepr Other Mycobact Dis 56 (1988) 552-558
13. Parkash O., Beuria M., Girdhar B.K., Katoch K., and Sengupta U. Efforts in diagnosing early leprosy using serological techniques. J Biosci 22 (1997) 111-116
14. Pistoor F.H., Rambukkana A., Kroezen M., et al. Novel predictive assay for contact allergens using human skin explant cultures. Am J Pathol 149 (1996) 337-343
15. Moschella S.L. An update on the diagnosis and treatment of leprosy. J Am Acad Dermatol 51 (2004) 417-426
16. Smelt A.H., Liew F.Y., and Rees R.J. Lymphocyte response of leprosy patients to human-derived and purified armadillo-derived Mycobacterium leprae, BCG and PPD. Clin Exp Immunol 34 (1978) 164-169
17. Verhagen C.E., Wierenga E.A., Buffing A.A., Chand M.A., Faber W.R., and Das P.K. Reversal reaction in borderline leprosy is associated with a polarized shift to type 1-like Mycobacterium leprae T cell reactivity in lesional skin: a follow-up study. J Immunol 159 (1997) 4474-4483
18. Bos J.D., de Boer O.J., Tibosch E., Das P.K., and Pals S.T. Skin-homing T lymphocytes: detection of cutaneous lymphocyte-associated antigen (CLA) by HECA-452 in normal human skin. Arch Dermatol Res 285 (1993) 179-183
19. Verhagen C.E., van der Pouw Kraan T.C., Buffing A.A., et al. Type 1- and type 2-like lesional skin-derived Mycobacterium leprae-responsive T cell clones are characterized by coexpression of IFN-gamma/TNF-alpha and IL-4/IL-5/IL-13, respectively. J Immunol 160 (1998) 2380-2387
20. Sehgal V.N., Gupta R.P., Karmakar S., Logani K.B., and Jain S. In situ characterization of lymphocytic immunophenotypes and interleukin-2 receptors in cutaneous tuberculosis and leprosy-a comparative evaluation. Clin Exp Dermatol 19 (1994) 312-316
21. Nilsen R., Mshana R.N., Negesse Y., Menigistu G., and Kana B. Immunohistochemical studies of leprous neuritis. Lepr Rev 57 Suppl 2 (1986) 177-187
22. Ahmed A.A., Nordlind K., Schultzberg M., and Liden S. Interleukin-1 alpha- and beta-, interleukin-6- and tumour necrosis factor-alpha-like immunoreactivities in chronic granulomatous skin conditions. Acta Derm Venereol 74 (1994) 435-440
23. Perosa F., Favoino E., Caragnano M.A., Prete M., and Dammacco F. CD20: a target antigen for immunotherapy of autoimmune diseases. Autoimmun Rev 4 (2005) 526-531
24. Chu P.G., and Arber D.A. CD79: a review. Appl Immunohistochem Mol Morphol 9 (2001) 97-106
25. O'Connell F.P., Pinkus J.L., and Pinkus G.S. CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms. Am J Clin Pathol 121 (2004) 254-263
26. Sinha S., Sengupta U., Ramu G., and Ivanyi J. Serological survey of leprosy and control subjects by a monoclonal antibody-based immunoassay. Int J Lepr Other Mycobact Dis 53 (1985) 33-38
27. Picker L.J., Michie S.A., Rott L.S., and Butcher E.C. A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. Am J Pathol 136 (1990) 1053-1068
28. Aarden L.A., and van Kooten C. The action of interleukin 6 on lymphoid populations. Ciba Found Symp 167 (1992) 68-74 [discussion 74-69]
29. Njoo D., Hu R.V.P., Tank B., et al. Detection of shared antigenic determinants between Mycobacterium leprae heat shock protein 65 and human heat shock protein 60. Hansenol Int 28 (2003) 31-43
30. Rambukkana A., Das P.K., Krieg S., et al. Mycobacterial 65,000 MW heat-shock protein shares a carboxy-terminal epitope with human epidermal cytokeratin 1/2. Immunology 77 (1992) 267-276
31. Lanzavecchia A. Mechanisms of antigen uptake for presentation. Curr Opin Immunol 8 (1996) 348-354
32. Regnault A., Lankar D., Lacabanne V., et al. Fc gamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med 189 (1999) 371-380
33. Tyagi P., Patil S.A., Girdhar B.K., Katoch K., and Sengupta U. Suppressive effect of circulating immune complexes from leprosy patients on the lymphocyte proliferation induced by M. leprae antigens in healthy responders. Int J Lepr Other Mycobact Dis 60 (1992) 562-569
34. Manca F., Fenoglio D., Li Pira G., Kunkl A., and Celada F. Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies. J Exp Med 173 (1991) 37-48
35. Morsy T.A., Essa M.H., Mangoud A.M., and Aboul Anin A.M. Evaluation of T cells, B cells and Ig in tissues of human cutaneous leishmaniasis. J Egypt Soc Parasitol 19 (1989) 57-66
36. Mahmoud F., Abul H., al Saleh Q., et al. Elevated B-lymphocyte levels in lesional tissue of non-arthritic psoriasis. J Dermatol 26 (1999) 428-433
37. Bosio C.M., Gardner D., and Elkins K.L. Infection of B cell-deficient mice with CDC 1551, a clinical isolate of Mycobacterium tuberculosis: delay in dissemination and development of lung pathology. J Immunol 164 (2000) 6417-6425