Phosphonic acid analogs of GABA through reductive dealkylation of phosphonic diesters with lithium trialkylborohydrides

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 13, 2007, Pages 3745-3748

  Chowdhury, Sarwat ^a   Muni, Niraj J ^a,b   Greenwood, Nicholas P ^a   Pepperberg, David R ^a,b   Standaert, Robert F ^c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b University of Illinois at Chicago   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

Dealkylation; GABA antagonists; GABAC receptors; Lithium trialkylborohydrides; Phosphonate esters

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID DERIVATIVE; ESTER DERIVATIVE; LITHIUM DERIVATIVE; NEUROTRANSMITTER; PHOSPHONIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEALKYLATION; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; IC 50; INHIBITION KINETICS; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; REDUCTION; XENOPUS LAEVIS;

ANIMALS; BOROHYDRIDES; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ESTERS; GAMMA-AMINOBUTYRIC ACID; INHIBITORY CONCENTRATION 50; LITHIUM; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; NEUROTRANSMITTER AGENTS; OOCYTES; PHOSPHONIC ACIDS; XENOPUS LAEVIS;

XENOPUS LAEVIS;

EID: 34250164283     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.026     Document Type: Article

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