A 14-mer peptide from HSP70 protein is the critical epitope which enhances NK activity against tumor cells in vivo

Immunological Investigations

Volumn 36, Issue 3, 2007, Pages 233-246

  Zhang, Honghai ^a   Liu, Rui ^a   Huang, Weida ^a,b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Hsp70; NK cell stimulatory; Tumor growth suppression

Indexed keywords

HEAT SHOCK PROTEIN 70; PEPTIDE; THREONYLARGINYLASPARTYLASPARAGINYLASPARAGINYLLEUCYLLEUCYLGLYCYL ARGINYLPHENYLALANYLGLUTAMINYLLEUCYLSERYLGLYCINE; THREONYLLYSYLASPARTYLASPARAGINYLASPARAGINYLLEUCYLLEUCYLGLYCYL ARGINYLPHENYLALANYLGLUTAMINYLLEUCYLSERYLGLYCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; IMMUNE RESPONSE; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TUMOR CELL; TUMOR IMMUNITY;

ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES; HSP70 HEAT-SHOCK PROTEINS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; PEPTIDES; T-LYMPHOCYTES;

EID: 34250163181     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.1080/08820130600992073     Document Type: Article

References (31)

1. Asea, A., Kraeft, S. K., Kurt-Jones, E. A., Stevenson, M. A., Chen, L. B., Finberg, R.W., Koo, G. C., Calderwood, S. K. (2000). HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nature Med. 6(4):435-442.
2. Asea, A., Rehli, M., Kabingu, E., Boch, J. A., Bare, O., Auron, P. E., Stevenson, M. A., Calderwood, S. K. (2002). Novel signal transduction pathway utilized by extracellular HSP70 - Role of Toll-like receptor (TLR) 2 AND TLR4. J. Biol. Chem. 77(17):15028-15034.
3. Basu, S., Binder, R. J., Ramalingam, T., Srivastava, P. K. (2001). CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity 14(3):303-313.
4. Becker, T., Hartl, F. U., Wieland, F. (2002). CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J. Cell Biol. 158(7):1277-1285.
5. Binder, R. J., Harris, M. L., Menoret, A., Srivastava, P. K. (2000). Saturation, competition, and specificity in interaction of heat shock proteins (hsp) gp96, hsp90, and hsp70 with CD11b(+) cells. J. Immunol. 165(5):2582-2587.
6. Blachere, N. E., Li, Z. H., Chandawarkar, R. Y., Suto, R., Jaikaria, N. S., Basu, S., Udono, H., Srivastava, P. K. (1997). Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J. Exper. Med. 186(8):1315-1322.
7. Casey, D. G., Lysaght, J., James, T., Bateman, A., Melcher, A. A., Todryk, S. M. (2003). Heat shock protein derived from a non-autologous tumour can be used as an antitumour vaccine. Immunology 110(1):105-111.
8. Chen, X. H., Tao, Q., Yu, H., Zhang, L. H., Cao, X. T. (2002). Tumor cell membrane-bound heat shock protein 70 elicits antitumor immunity. Immunol. Lett. 84(2):81-87.
9. Denagel, D. C., Pierce, S. K. (1992). A case for chaperones in antigen processing. Immunol. Today 13(3):86-89.
10. Ferrarini, M., Heltai, S., Zocchi, M. R., Rugarli, C. (1992). Unusual expression and localization of heat-shock proteins in human tumor-cells. Intl. J. Cancer 51(4):613-619.
11. Gastpar, R., Gross, C., Rossbacher, L., Ellwart, J., Riegger, J., Multhoff, G. (2004). The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells. J. Immunol. 172(2):972-980.
12. Gross, C., Koelch, W., DeMaio, A., Arispe, N., Multhoff, G. (2003). Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. J. Biol. Chem. 278(42):41173-41181.
13. Hartl, F. U. (1996). Molecular chaperones in cellular protein folding. Nature 381:571-580.
14. Karre, K., Ljunggren, H. G., Piontek, G., Kiessling, R. (2005). Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy (Reprinted from Nature 319:675-678 (1986)). J. Immunol. 174(11):6566-6569.
15. Lindquist, S., Craig, E. A. (1988). The heat shock proteins. Annu. Rev. Genet. 22:631-677.
16. Ma, J. H., Sui, Y. F., Ye, J., Huang, Y. Y., Li, Z. S., Chen, G. S., Qu, P., Song, H. P., Zhang, X. M. (2005). Heat shock protein 70/MAGE-3 fusion protein vaccine can enhance cellular and humoral immune responses to MAGE-3 in vivo. Cancer Immunol. Immunother. 54(9):907-914.
17. Menoret, A. (2004). Purification of recombinant and endogenous HSP70s. Methods 32(1):7-12.
18. Miller, J. S. (2002). Biology of natural killer cells in cancer and infection. Cancer Investig. 20(3):405-419.
19. Morimoto, R. I. (1993). Cells in stress - Transcriptional activation of heat-shock genes. Science 259(5100):1409-1410.
20. Multhoff, G. (2002). Activation of natural killer cells by heat shock protein 70. Intl. J. Hyperthermia 18(6):576-585.
21. Multhoff, G., Botzler, C., Jennen, L., Schmidt, J., Ellwart, J., Issels, R. (1997). Heat shock protein 72 on tumor cells - A recognition structure for natural killer cells. J. Immunol. 158(9):4341-4350.
22. Multhoff, G., Botzler, C., Wiesnet, M., Eissner, G., Issels, R. (1995). Cd3(-) Large Granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-Kd heat-shock protein on human sarcoma-cells. Blood 86(4):1374-1382.
23. Multhoff, G., Botzler, C., Wiesnet, M., Muller, E., Meier, T., Wilmanns, W., Issels, R. D. (1995). A stress-inducible 72-Kda heat-shock protein (Hsp72) is expressed on the surface of human tumor-cells, but not on normal-cells. Intl. J. Cancer 61(2):272-279.
24. Multhoff, G., Mizzen, L., Winchester, C. C., Milner, C. M, Wenk, S., Eissner, G., Kampinga, H. H., Laumbacher, B., Johnson, J. (1999) Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Exper. Hematol. 27(11):1627-1636.
25. Multhoff, G., Pfister, K., Gehrmann, M., Hantschel, M., Gross, C., Hafner, M., Hiddemann, W. (2001). A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity. Cell Stress Chaperones 6(4):337-344.
26. Seaman, W. E. (2000) Natural killer cells and natural killer T cells. Arthritis Rheum. 43(6):1204-1217.
27. Suto, R., Srivastava, P. K. (1995). A mechanism for the specific immunogenicity of heat-shock protein-chaperoned peptides. Science 269(5230):1585-1588.
28. Suzue, K., Zhou, X. Z., Eisen, H. N., Young, R. A. (1997). Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway. Proc. Natl. Acad. Sci. USA 94(24):13146-13151.
29. Tarkkanen, J., Kosunen, T. U., Saksela, E. (1993). Contact of lymphocytes with Helicobacter-pylori augments natural-killer-cell activity and induces production of gamma-interferon. Infect. Immun. 61(7):3012-3016.
30. Udono, H., Srivastava, P. K. (1994). Comparison of tumor-specific immunogenicities of stress-induced proteins Gp96, Hsp90, And Hsp70. J. Immunol. 152(11):5398-5403.
31. Wang, Y. F., Kelly, C. G., Karttunen, J. T., Whittall, T., Lehner, P. J., Duncan, L., MacAry, P., Younson, J. S., Singh, M., Oehlmann, W., Cheng, G. H., Bergmeier, L., Lehner, T. (2001). CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines. Immunity 15(6):971-983.