Hyperammonemic coma - Barking up the wrong tree

Journal of General Internal Medicine

Volumn 22, Issue 4, 2007, Pages 549-552

  Rimar, Doron ^a,b   Kruzel Davila, Eti ^a   Dori, Guy ^a   Baron, Elzbieta ^a   Bitterman, Haim ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b CARMEL MEDICAL CENTER   (Israel)

Author keywords

Autoimmune hepatitis; Autoimmune polyglandular syndrome type 2; Hepatic encephalopathy; Hyperammonemia; Myxedema coma; Urea cycle

Indexed keywords

HYDROCORTISONE; LACTULOSE; LEVOTHYROXINE; NEOMYCIN;

AGED; ANAMNESIS; ARTICLE; BLOOD ANALYSIS; CASE REPORT; CLINICAL FEATURE; COMA; COMPUTER ASSISTED TOMOGRAPHY; ELECTROENCEPHALOGRAPHY; FEMALE; GLASGOW COMA SCALE; HEPATIC ENCEPHALOPATHY; HUMAN; HYPERAMMONEMIA; HYPOTHYROIDISM; LABORATORY TEST; LUMBAR PUNCTURE; NEUROLOGIC EXAMINATION; PHYSICAL EXAMINATION; DIFFERENTIAL DIAGNOSIS; PATHOPHYSIOLOGY;

AGED, 80 AND OVER; COMA; DIAGNOSIS, DIFFERENTIAL; FEMALE; HEPATIC ENCEPHALOPATHY; HUMANS; HYPERAMMONEMIA; HYPOTHYROIDISM;

EID: 34250162530     PISSN: 08848734     EISSN: 15251497     Source Type: Journal    
DOI: 10.1007/s11606-007-0131-6     Document Type: Article

References (22)

1. Wall CR. Myxedema coma: diagnosis and treatment. Am Fam Phys. 2000;62(11):2485-90.
2. Bickford RG, Butt HR. Hepatic coma: the electroencephalographic pattern. J Clin Invest. 1955;34:790-99.
3. Karnaze DS, Bickford RG. Triphasic waves: a reassessment of their significance. Electroencephalogr Clin Neurophysiol. 1984;57(3):193-8.
4. River Y, Zelig O. Triphasic waves in myxedema coma. Clin Electroencephalogr. 1993;24(3):146-50.
5. Cindoruk M, Yetkin I, Karakan T, et al. The prevalence of autoimmune hepatitis in hashimoto's thyroiditis in a Turkish population. Acta Gastroenterol Belg. 2002;65(3):143-5.
6. Zeniya M. Thyroid disease in autoimmune liver diseases. Nippon Rinsho. 1999;57(8):882-7.
7. Antonelli A, Ferri C, Pampana A, et al. Thyroid disorders in chronic hepatitis C. Am J Med. 2004;117(1):10-3.
8. Tajiri J, Shimada T, Naomi S, et al. Hepatic dysfunction in primary hypothyroidism. Endocrinol Jpn. 1984;31(1):83-91.
9. Marti J, Portoles M, Jimenez-Nacher I, et al. Effect of thyroid hormones on urea biosynthesis and related processes in rat liver. Endocrinology. 1988;123:2167-74.
10. Baker A, Kaplan M, Wolfe H. Central congestive fibrosis of the liver in myxedema ascites. Ann Intern Med. 1972;77(6):927-9.
11. McCall M, Bourgeois JA. Valproic acid-induced hyperammonemia: a case report. J Clin Psychopharmacol. 2004;24(5):521-6.
12. Kim YA, Chung HC, Choi HJ, Rha SY, Seong JS, Jeung HC. Intermediate dose 5-fluorouracil-induced encephalopathy. Jpn J Clin Oncol. 2006;36(1):55-9.
13. Cheang HK, Rangecroft L, Plant ND, Morris AA. Hyperammonaemia due to Klebsiella infection in a neuropathic bladder. Pediatr Nephrol. 1998;12(8):658-9.
14. Thobe N, Pilger P, Jones MP. Primary hypothyroidism masquerading as hepatic encephalopathy: case report and review of the literature. Postgrad Med J. 2000;76(897):424-6.
15. Hitoshi S, Terao Y, Sakuta M. Portal-systemic encephalopathy and hypothalamic hypothyroidism: effect of thyroid hormone on ammonia metabolism. Intern Med. 1993;32(8):655-8.
16. Yamamoto T, Takeuchi K, Okuda C, et al. Symptomatic hypothyroidism in decompensated liver cirrhosis. J Clin Gastroenterol. 2001;33(2):172-3.
17. Hashiguchi H, Mera T, Hashimoto T, Tsuji S. A case of portal-systemic encephalopathy associated with Sheehan's syndrome. Rinsho Shinkeigaku. 2000;40(2):131-4.
18. De Nardo D, Franconi G, Sabino D. Hyperammonemia during hypothyroidism: an unusual biohumoral finding normalized by hormonal replacement treatment. Ann Ital Med Interna. 1999;14(3):196-201.
19. Grofte T, Wolthers T, Jensen DS, et al. Hepatic amino nitrogen conversion and organ N-contents in hypothyroidism, with thyroxine replacement, and in hyperthyroid rats. J Hepatol. 1997;26(2):409-16.
20. Marchesini G, Fabbri A, Bianchi GP, et al. Hepatic conversion of amino nitrogen to urea nitrogen in hypothyroid patients and upon l-thyroxine therapy. Metabolism. 1993;42(10):1263-9.
21. Ingbar SH. Effects of thyroid hormones on metabolic processes. In: Williams Textbook of Endocrinology, 7th Edition. Philadelphia: WB Saunders, 1985:738.
22. Burstein PJ, Draznin B, Johnson CJ, et al. The effect of hypothyroidism on growth, serum growth hormone, the growth hormone-dependent somatomedin, insulin-like growth factor, and its carrier protein in rats. Endocrinology. 1979;104(4):1107-11.