Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design

Journal of Molecular Biology

Volumn 370, Issue 5, 2007, Pages 812-825

  Lee, Mihwa ^a   Chan, Camilla W ^a   Graham, Stephen C ^a   Christopherson, Richard I ^a   Guss, J Mitchell ^a   Maher, Megan J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

carbamyl aspartate; dihydroorotase; dihydroorotate; flexible loop; inhibitor design

Indexed keywords

2 OXO 1,2,3,6 TETRAHYDROPYRIMIDINE 4,6 DICARBOXYLATE; DIHYDROOROTASE; FLUOROOROTIC ACID; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG INHIBITION; DRUG STRUCTURE; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL;

ESCHERICHIA COLI;

EID: 34250158790     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.05.019     Document Type: Article

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