If current and heart rate control;Corrente If e o controle da freqüência cardíaca

Arquivos Brasileiros de Cardiologia

Volumn 88, Issue 4, 2007, Pages

  César, Luiz Antonio Machado ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

Arrhytmia; Heart rate

Indexed keywords

AMLODIPINE; ATENOLOL; IVABRADINE; PLACEBO; ZATEBRADINE; BENZAZEPINE DERIVATIVE; CALCIUM CHANNEL; CYCLIC NUCLEOTIDE GATED CHANNEL; SODIUM CHANNEL; UNCLASSIFIED DRUG;

CELL MEMBRANE DEPOLARIZATION; CLINICAL TRIAL; CORONARY ARTERY DISEASE; DRUG ACTIVITY; DRUG EFFICACY; DRUG SAFETY; ELECTROCARDIOGRAM; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART RATE; HUMAN; LABORATORY TEST; REVIEW; STABLE ANGINA PECTORIS; VISUAL DISORDER; ACTION POTENTIAL; ANGINA PECTORIS; ANIMAL; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG EFFECT; ELECTRIC CONDUCTIVITY; METABOLISM; PHYSIOLOGY; RABBIT; SINUS NODE;

ACTION POTENTIALS; ANGINA PECTORIS; ANIMALS; BENZAZEPINES; CALCIUM CHANNELS; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; ELECTRIC CONDUCTIVITY; HEART RATE; HUMANS; MEMBRANE POTENTIALS; RABBITS; SINOATRIAL NODE; SODIUM CHANNELS;

EID: 34250021393     PISSN: 0066782X     EISSN: 16784170     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. Brown HF, Di Francesco D, Noble SJ. How does adrenaline accelerate the heart? Nature. 1979; 280: 235-6.
2. Noble D, Tsie RW. The kinetics and rectifier properties of the slow potassium current in calf Purkinje fibres. J Physiol. 1968; 195: 185-214.
3. DiFrancesco D. A new interpretation of the pacemaker current in calf Purkinje fibres. J Physiol. 1981; 314: 359-76.
4. DiFrancesco D. A study of the ionic nature of pacemaker current in calf Purkinje fibres J Physiol. 1981; 314: 377-93.
5. DiFrancesco D. The cardiac hyperpolarizing-activated curret, If: origins and developments. Prog Biophys Mol Biol. 1985; 46: 163-83.
6. Biel M, Ludwig A, Zong X, Hofmann F. Hyperpolarization-activated cation channels: a multi-gene family. Rev Physiol Biochem Pharmacol. 1999; 136: 165-81.
7. Kaupp UB, Seifert R. Molecular diversity of pacemaker ion channels. Annu Rev Physiol. 2001; 63: 235-57.
8. Accili EA, Proenza C, Baruscotti M, DiFrancesco D. From funny current to HCN channels: 20 years of excitation. N Physiol Sci. 2002; 17: 32-7.
9. Pape HC. Qeer current and pacemaker. The hyperpolarization-activated cation current in neurons. Annu Rev Physiol. 1996; 58: 299-327.
10. DiFrancesco D, Ferroni A, Mazzanti M, Tromba C. Properties of the hyperpolarizing-activated current (If) in cells isolated from the rabbit sino-atrial node. J Physiol. 1986; 377: 61-88.
11. DiFrancesco D. Block and activation of the pace-maker channel in calf Purkinje fibres: effects of potassium, caesium and rubidium. J Physiol. 1982; 329: 485-507.
12. Di Francesco D, Some properties of the UL-FS 49 block of the hyperpolarization-activated current (If) in sino-atrial node myocites. Pflugers Arch. 1994; 427: 64-70.
13. Gardiner SM, Kemp PA, March JE, Bennett T. Acute and chronic cardiac and regional haemodynamic effects of the novel bradycardic agent, S6257, in conscious rats. Br J Pharmacol. 1995; 115: 579-86.
14. Monnet X, Chaleh B, Colin P, de Curzon DP, Giudicelli JF, Berdeaux A. Effects of heart rate reduction with ivabradine on exercise-induced myocardial ischemia and stunning. J Pharmacol Exp Ther. 2001; 299: 1133-9.
15. Bois P, Bescon J, Renaudon B, Lenfant J. Mode of action of bradycardic agent, S 16257, on ions currents of rabbit sinoatrial node cells. Br J Pharmacol. 1996; 118: 1051-7.
16. Simon L, Gheleh B, Puybasset L, Giudicelli J-F, Berdeaux A. Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exerxising conscious dogs. J Pharmacol Exp Ther. 1995; 275: 659-66.
17. Ragueneau I, LAveille C, Jochemsen R, Resplandy G, Funck-Brentano C, Jaillon P. Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers. Clin Pharamcol Ther. 1998; 64: 192-203.
18. Borer SS, Fox K, Jaillon P, Lerebours G; Ivabradine Investigators Group. Antianginal and Antiischemic Effects of Ivabradine,an If Inhibitor, in Stable Angina. A Randomized, Double-Blind, Multicentered, Placebo-Controlled Trial. Circulation. 2003; 107: 817-23.
19. Tardif JC, Ford I, Tendera M, Fox K. On Behalf: the INITIATIVE study investigators. Anti-anginal and anti-ischaemic effects of the If current inhibitor ivabradine versus atenolol in stable angina. A 4-month randomised, double-blind, multicenter trial. Eur Heart J. 2003; 20 (suppl): 24.
20. Ruzyllo W, Ford F, Tendera M, Fox K. On behalf: the study investigators. Antianginal and antiischaemic effects of the If current inhibitor ivabradine compared to amlodipine as monotherapies in patients with chronic stable angina. Randomised, controlled, double-blind trial Eur Heart J. 2004; 25 (Suppl): 138.