Effects of heart rate reduction with ivabradine on exercise-induced myocardial ischemia and stunning

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 3, 2001, Pages 1133-1139

  Monnet, Xavier ^a   Ghaleh, Bijan ^a   Colin, Patrice ^a   Parent De Curzon, Olivier ^a   Giudicelli, Jean François ^a   Berdeaux, Alain ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IVABRADINE; MEMBRANE AFFECTING AGENT; UNCLASSIFIED DRUG;

AORTA PRESSURE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY OBSTRUCTION; DOG; DRUG EFFECT; EXERCISE; HEART ATRIUM PACING; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; NONHUMAN; PRIORITY JOURNAL; STUNNED HEART MUSCLE;

EID: 0035192922     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Opposed responses of large and small coronary arteries to propranolol during exercise in dogs
2. Mode of action of bradycardic agent, S 16 257, on ionic currents of rabbit sino-atrial node cells
3. Effect of intravenous propranolol on coronary vasomotion at rest and during dynamic exercise in patients with coronary artery disease
4. Actions of two new bradycardic agents, AQ-AH 208 and UL-FS 49, on ischemic myocardial perfusion and function
5. Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency
6. Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors
7. Comparative effects of a potassium channel blocking drug, UK-68 798, and a specific bradycardic agent, UL-FS 49, on exercise-induced ischemia in the dog: Significance of diastolic time on ischemic cardiac function
8. Beneficial effects of two bradycardic agents AQ-A39 (Falipamil) and AQ-AH 208 on reversible myocardial reperfusion damage in anesthetized dogs
9. Effects of bradycardic agents on ischaemic myocardium and perfusion in anesthetized dogs
10. Elimination of exercise-induced regional myocardial dysfunction by a bradycardic agent in dogs with chronic coronary stenosis
11. Influence of heart rate on mortality after acute myocardial infarction
12. Persistence of regional left ventricular dysfunction after exercise-induced myocardial ischemia
13. Mechanisms of improved ischemic regional dysfunction by bradycardia: Studies on UL FS 49 in swine
14. Experimental and clinical observations on the efficacy of esmolol in myocardial ischemia
15. Clinical effects of beta-adrenergic blockade in chronic heart failure: A meta-analysis of double-blind, placebo-controlled, randomized trials
16. Effects of the combination of diltiazem and atenolol on exercise-induced regional myocardial ischemia in conscious dogs
17. Lack of effects of the Na+/H+ exchanger inhibitor, cariporide against myocardial stunning in exercise-induced ischemia in dogs
18. Myocardial stunning in exercise-induced ischemia in dogs: Lack of late preconditioning
19. Beneficial effects of the T- and L-type calcium channel antagonist, mibefradil, against exercise-induced myocardial stunning in dogs
20. Is "stunned myocardium" a protective mechanism? Effect of acute recruitment and acute β-blockade on recovery of contractile function and high-energy phosphate stores at 1 day post-reperfusion
21. Effects of the bradycardic agent UL-FS 49 on exercise-induced regional contractile dysfunction in dogs
22. Less afterload sensitivity in short-term hibernating than in acutely ischemic and stunned myocardium
23. Differences in myocardial stunning following coronary artery occlusion in conscious dogs, pigs, and baboons
24. Coronary hemodynamic effects of S 16 257, a new bradycardic agent, in resting and exercising conscious dogs
25. 2+ sensitization predominantly enhances function and mechanical efficiency of stunned myocardium
26. Late preconditioning against myocardial stunning: An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs
27. Time course of late preconditioning against myocardial stunning in conscious pigs
28. Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S 16257
29. Electrophysiological effects of S 16 257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: Comparison with UL-FS 49