Development of a sensitive liquid chromatography method coupled with a tandem mass spectrometric detection for the clinical analysis of vinflunine and 4-O-deacetyl vinflunine in blood, urine and faeces

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 853, Issue 1-2, 2007, Pages 294-302

  Zorza, G ^a   Van Heugen, J C ^b   De Graeve, J ^b   Puozzo, C ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

4 O Deacetyl vinflunine; Human; LC MS MS; Metabolites; Vinflunine

Indexed keywords

4-O-DEACETYL VINFLUNINE; BIOLOGICAL MEDIA; CLINICAL ANALYSIS; VINFLUNINE;

BLOOD; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES;

PHARMACODYNAMICS;

4 O DEACETYLVINFLUNINE; BLOOD EXTRACT; DRUG METABOLITE; UNCLASSIFIED DRUG; VINBLASTINE; VINFLUNINE;

ARTICLE; BLOOD ANALYSIS; CONCENTRATION (PARAMETERS); DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG FECES LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; ELECTROSPRAY; FECES ANALYSIS; HUMAN; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; STANDARD; TANDEM MASS SPECTROMETRY; URINALYSIS; VALIDATION PROCESS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; HUMANS; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; VINBLASTINE;

EID: 34250014751     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.03.030     Document Type: Article

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