Autoradiographic localization of aromatic hydrocarbon receptor (AHR) in rhesus monkey ovary

American Journal of Primatology

Volumn 69, Issue 6, 2007, Pages 681-691

  Baldridge, Monika G ^a   Hutz, Reinhold J ^b,c  

^a Carroll College Waukesha   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

Author keywords

AHR; Follicle; Macaca mulatta; Ovary; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA NAPHTHOFLAVONE; ALPHA-NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; BENZOFLAVONE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG;

AROMATIC HYDROCARBON; ORGANIC POLLUTANT; POLLUTION EFFECT; PRIMATE; REPRODUCTIVE BIOLOGY; STEROID; TCDD;

ANIMAL; ARTICLE; AUTORADIOGRAPHY; COMPARATIVE STUDY; DRUG ANTAGONISM; FEMALE; GRANULOSA CELL; IMAGE PROCESSING; MACACA; METABOLISM; STATISTICAL MODEL; ULTRAMICROTOMY;

ANIMALS; AUTORADIOGRAPHY; BENZOFLAVONES; CRYOULTRAMICROTOMY; FEMALE; GRANULOSA CELLS; IMAGE PROCESSING, COMPUTER-ASSISTED; LINEAR MODELS; MACACA MULATTA; RECEPTORS, ARYL HYDROCARBON; TETRACHLORODIBENZODIOXIN; TRITIUM;

MACACA; MACACA MULATTA; PRIMATES;

EID: 34250005448     PISSN: 02752565     EISSN: 10982345     Source Type: Journal    
DOI: 10.1002/ajp.20381     Document Type: Article

References (41)

1. Baldridge MG, Stahl RL, Gerstenberger SL, Tripoli V, Hutz RJ. 2003. Modulation of ovarian follicle maturation in Long-Evans rats exposed to polychlorinated biphenyls in utero and lactationally. Reprod Toxicol 17: 567-573.
2. Beischlag TV, Wang S, Rose D, Torchia J, Reisz-Porszasz S, Muhammed K, Nelson WE, Probst MR, Rosenfeld MG, Hankinson O. 2002. Recruitment of the NCoA/SRC-1/ p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol Cell Biol 22:4319-4333.
3. Benedict JC, Lin TM, Loeffler IK, Peterson RE, Flaws JA. 2000. Physiological role of the aryl hydrocarbon receptor in mouse ovary development. Toxicol Sci 56:382-388.
4. Birnbaum LS. 1995. Developmental effects of dioxins and related endocrine disrupting chemicals. Toxicol Lett 82/83:743-750.
5. Borman SM, Christian PJ, Sipes IG, Hoyer PB. 2000. Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index. Toxicol Appl Pharmacol 167:191-198.
6. Chaffin CL, Heimler I, Rawlins RG, Wimpee BA, Sommer C, Hutz RJ. 1996a. Estrogen receptor and aromatic hydrocarbon receptor in the primate ovary. Endocrine 5:315-321.
7. Chaffin CL, Peterson RE, Hutz RJ. 1996b. In utero and lactational exposure of female Holtzman rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin: modulation of the estrogen signal. Biol Reprod 55:62-67.
8. Chaffin CL, Hutz RJ. 1997. Regulation of the aromatic hydrocarbon receptor (AHR) by in utero and lactational exposure to 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD). J Reprod Dev 43:47-51.
9. Chen I, Hsieh T, Thomas T, Safe S. 2001. Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization. Gene 262:207-214.
10. Chen J, Laughlin LS, Hendrickx AG, Natarajan K, Overstreet JW, Lasley BL. 2003. The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotrophin activity in pregnant macaques. Toxicology 186:21-31.
11. Colburn T, von Saal FS, Soro AM. 1993. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 101:378-384.
12. Colburn T, Dumanski D, Meyers JP. 1996. Our stolen future. New York: Penguin Books, p 1-305.
13. Conley LK, White G, Hutz RJ. 2005. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters estradiol release from monkey ovarian fragments in vitro. Proc Soc Study Reprod, Quebec City, Quebec, Canada, July 24-27, 38th Annual Meeting of SSR, 2005.
14. Dasmahapatra AK, Wimpee BA, Trewin AL, Wimpee CF, Ghorai JK, Hutz RJ. 2000. Demonstration of 2,3,7,8-tetrachlorodibenzo-p-dioxin attenuation of P450 steroidogenic enzyme mRNAs in rat granulosa cell in vitro by competitive reverse transcriptase-polymerase chain reaction assay. Mol Cell Endocrinol 164:5-18.
15. Dasmahapatra AK, Wimpee BA, Trewin AL, Hutz RJ. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases steady-state estrogen receptor-β mRNA levels after CYP1A1 and CYP1B1 induction in rat granulosa cells in vitro. Mol Cell Endocrinol 182:39-48.
16. Dolwick KM, Schmidt JV, Carver LA, Swanson HI, Bradfield CA. 1993. Cloning and expression of the human Ah receptor cDNA. Mol Pharmacol 44:911-917.
17. Gray LE Jr, Ostby JS. 1995. In utero 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology and function in female rat offspring. Toxicol Appl Pharmacol 13:285-294.
18. Gregoraszcuk EL. 2002. Dioxin exposure and porcine reproductive hormonal activity. Cad Saude Publica 18:453-462. [Portuguese]
19. Guo SW. 2004. The link between exposure to dioxin and endometriosis: A critical reappraisal of primate data. Gynecol Obstet Invest 57:157-173.
20. Heimler I, Trewin AL, Chaffin CL, Rawlins RG, Hutz RJ. 1998a. Modulation of ovarian follicle maturation and effects on apoptotic cell death in Holtzman rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and lactationally. Reprod Toxicol 12:69-73.
21. Heimler I, Rawlins RG, Owen H, Hutz RJ. 1998b. Dioxin Perturbs, in a dose- and time-dependent fashion, steroid secretion, and induces apoptosis of human luteinized granulosa cells. Endocrinology 139:4373-4379.
22. Hombach-Klonisch S, Pocar P, Kietz S, Klonisch T. 2005. Molecular actions of polyhalogenated arylhydrocarbons (PAHs) in female reproduction. Curr Med Chem 12:599-616.
23. Hutz RJ, Wagner N, Krause P, Fisher C, Syed N, Dierschke DJ, Monniaux D, Tomanek M. 1993. Localization of estrogen receptors in rhesus monkey ovary. Am J Primatol 31: 299-309.
24. Hutz RJ. 1999. Reproductive endocrine disruption by environmental xenobiotics that modulate the estrogen-signaling pathway, particularly by tetrachlorodibenzo-p-dioxin (TCDD). J Reprod Dev 45:1-12.
25. Janosek J, Hilscherova K, Blaha L, Holoubek I. 2006. Environmental xenobiotics and nuclear receptors-interactions, effects and in vitro assessment. Toxicol In Vitro 20:18-37.
26. Johnson HT, Keile JE, Gaddy RG, Loadholt CB, Hennigar GR, Wader EM. 1976. Prolonged investigation of commercial DDT and PCB: Effects on progesterone levels and reproduction in the mature female rat. Arch Environ Contam Toxicol 3:479-483.
27. Kharat I, Saatcioglu F. 1996. Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. Cross-talk between aryl hydrocarbon- and estrogen-mediated signaling. J Biol Chem 271:10533-10537.
28. McLachlan JA, Korach KS. 1994. In Proceedings of the Meeting: Estrogens in the Environment III: Global health implications, Washington, DC. Environ Health Perspect Suppl 7:1-178.
29. Moran FM, Tarara R, Chen J, Santos S, Cheney A, Overstreet JW, Lasley BL. 2001. Effect of dioxin on ovarian function in the cynomolgus macaque (M. fascicularis). Reprod Toxicol 15:377-383.
30. Moran FM, VandeVoort CA, Overstreet JW, Lasley BL, Conley AJ. 2003. Molecular target of endocrine disruption in human luteinizing granulosa cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin: inhibition of estradiol secretion due to decreased 17alpha-hydroxylase/17,20-lyase cytochrome P450 expression. Endocrinology 144:467-473.
31. Ohtake F, Takeyama K, Matsumoto T, Kitagawa H, Yamamoto Y, Nohara K, Tohyama C, Krust A, Mimura J, Chambon P, Yanagisawa J, Fujii-Kuriyama Y, Kato S. 2003. Modulation of oestrogen receptor signaling by association with the activated dioxin receptor. Nature 423:545-550.
32. Peluso JJ, Hutz RJ. 1980. The effect of age on the ability of oocytes to synthesize RNA and protein during in-vitro maturation. Cell Tissue Res 213:29-35.
33. Poland A, Knutson JC. 1982. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 22:517-554.
34. Probst MR, Reisz-Porszasz S, Agbunag RV, Ong MS, Hankinson O. 1993. Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Mol Pharmacol 87:306-314.
35. Rier SE, Martin DC, Bowman RE, Dmoski WP, Becker JL. 1993. Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol 21:433-441.
36. Safe SH. 1995. Modulation of gene expression and endocrine response pathways by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related compounds. Pharmacol Ther 67:247-281.
37. Safe S, Wormke M, Samudio I. 2000. Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells [Review]. J Mammary Gland Biol Neoplasia 5:295-306.
38. Salisbury TB, Marcinkiewicz JL. 2002. In utero and lactational exposure to 2,3,7, 8-tetrachlorodibenzo-p-dioxin and 2,3,4,7, 8-pentachlorodibenzofuran reduces growth and disrupts reproductive parameters in female rats. Biol Reprod 66:1621-1626.
39. Song J, Clagett-Dame M, Peterson RE, Hahn ME, Westler WM, Sicinski RR, DeLuca HF. 2002. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci USA 99:14694-14699.
40. Whitlock JP Jr. 1993. Mechanistic aspects of dioxin action. Chem Res Toxicol 6:754-763.
41. Wolf CJ, Ostby JS, Gray LE Jr. 1999. Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) severely alters reproductive function of female hamster offspring. Toxicol Sci. 51:259-264.