NADPH binding to β-subunit regulates inactivation of voltage-gated K+ channels

Biochemical and Biophysical Research Communications

Volumn 359, Issue 2, 2007, Pages 269-276

  Tipparaju, Srinivas M ^a   Liu, Si Qi ^a   Barski, Oleg A ^a   Bhatnagar, Aruni ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Aldo keto reductase; K+ channels; Kv subunits; Oxygen sensing; Patch clamp; Pyridine coenzyme nucleotides; Pyridine nucleotides

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BINDING SITE; GENE MUTATION; GENETIC TRANSFECTION; HYPERPOLARIZATION; IMMUNOLOCALIZATION; NONHUMAN; PIPETTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RAT;

ALCOHOL OXIDOREDUCTASES; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; GENE EXPRESSION REGULATION; HUMANS; KINETICS; MOLECULAR CONFORMATION; NADP; NUCLEOTIDES; OXYGEN; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS;

RATTUS;

EID: 34249979228     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.05.102     Document Type: Article

References (23)

1. Deal K.K., England S.K., and Tamkun M.M. Molecular physiology of cardiac potassium channels. Physiol. Rev. 76 (1996) 49-67
2. Kolb H.A. Potassium channels in excitable and non-excitable cells. Rev. Physiol. Biochem. Pharmacol. 115 (1990) 51-91
3. + channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J. Clin. Invest. 101 (1998) 2319-2330
4. + channels. Am. J. Physiol. Lung Cell. Mol. Physiol. 281 (2001) L1-L12
5. + channel(s): where and what?. Am. J. Physiol. 281 (2001) L1345-L1349
6. Martens J.R., Kwak Y.G., and Tamkun M.M. Modulation of Kv channel alpha/beta subunit interactions. Trends Cardiovasc. Med. 9 (1999) 253-258
7. Xu J., and Li M. Auxiliary subunits of Shaker-type potassium channels. Trends Cardiovasc. Med. 8 (1998) 229-234
8. + channels altered by presence of beta-subunit. Nature 369 (1994) 289-294
9. Jez J.M., Flynn T.G., and Penning T.M. A new nomenclature for the aldo-keto reductase superfamily. Biochem. Pharmacol. 54 (1997) 639-647
10. + channel. J. Biol. Chem. 276 (2001) 11812-11820
11. + channels by oxidized and reduced pyridine nucleotide coenzymes. Am. J. Physiol. Cell Physiol. 288 (2005) C366-C376
12. Kumar R., Namiki T., and Joyner R.W. Effects of cGMP on L-type calcium current of adult and newborn rabbit ventricular cells. Cardiovasc. Res. 33 (1997) 573-582
13. Mishra M., Wagner M.B., Wang Y., Joyner R.W., and Kumar R. Expression of cGMP-dependent protein kinase in human atrium. J. Mol. Cell. Cardiol. 33 (2001) 1467-1476
14. + channel Kv beta 1.3 beta-subunit affect voltage-dependent gating. Am. J. Physiol. 43 (1998) C1485-C1495
15. + channel beta subunit. Cell 97 (1999) 943-952
16. Bahring R., Milligan C.J., Vardanyan V., Engeland B., Young B.A., Dannenberg J., Waldschutz R., Edwards J.P., Wray D., and Pongs O. Coupling of voltage-dependent potassium channel inactivation and oxidoreductase active site of Kv beta subunits. J. Biol. Chem. 276 (2001) 22923-22929
17. Campomanes C.R., Carroll K.I., Manganas L.N., Hershberger M.E., Gong B., Antonucci D.E., Rhodes K.J., and Trimmer J.S. Kv beta subunit oxidoreductase activity and Kv1 potassium channel trafficking. J. Biol. Chem. 277 (2002) 8298-8305
18. Peri R., Wible B.A., and Brown A.M. Mutations in the Kv beta 2 binding site for NADPH and their effects on Kv1.4. J. Biol. Chem. 276 (2001) 738-741
19. Weir E.K., Lopez-Barneo J., Buckler K.J., and Archer S.L. Acute oxygen-sensing mechanisms. N. Engl. J. Med. 353 (2005) 2042-2055
20. Wolin M.S., Ahmad M., and Gupte S.A. Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH. Am. J. Physiol. Lung Cell. Mol. Physiol. 289 (2005) L159-L173
21. Ceconi C., Bernocchi P., Boraso A., Cargnoni A., Pepi P., Curello S., and Ferrari R. New insights on myocardial pyridine nucleotides and thiol redox state in ischemia and reperfusion damage. Cardiovasc. Res. 47 (2000) 586-594
22. Heinemann S.H., and Hoshi T. Multifunctional potassium channels: electrical switches and redox enzymes, all in one. Sci. STKE 2006 (2006) e33
23. Weng J., Cao Y., Moss N., and Zhou M. Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase. J. Biol. Chem. 281 (2006) 15194-15200