Role of the stage-regulated nucleoside transporter TbNT10 in differentiation and adenosine uptake in Trypanosoma brucei

Molecular and Biochemical Parasitology

Volumn 154, Issue 1, 2007, Pages 110-114

  Spoerri, Iris ^a   Chadwick, Ruth ^b   Renggli, Christina Kunz ^c   Matthews, Keith ^b   Roditi, Isabel ^a   Burkard, Gabriela ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Adenosine; Differentiation; Nucleoside transporter; Stumpy inducing factor; Trypanosomes

Indexed keywords

ADENOSINE; NUCLEOSIDE TRANSPORTER; NUCLEOSIDE TRANSPORTER TBNT10; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; NONHUMAN; NORTHERN BLOTTING; PARASITE EXAMINATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SOUTHERN BLOTTING; TRYPANOSOMA BRUCEI;

ADENOSINE; ANIMALS; MORPHOGENESIS; NUCLEOSIDE TRANSPORT PROTEINS; PROTOZOAN PROTEINS; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA BRUCEI;

EID: 34249949077     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2007.04.006     Document Type: Article

References (20)

1. Hammond D.J., and Gutteridge W.E. Purine and pyrimidine metabolism in the Trypanosomatidae. Mol Biochem Parasitol 13 (1984) 243-261
2. Carter N.S., and Fairlamb A.H. Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature 361 (1993) 173-176
3. Mäser P., Sutterlin C., Kralli A., and Kaminsky R. A nucleoside transporter from Trypanosoma brucei involved in drug resistance. Science 285 (1999) 242-244
4. Burchmore R.J., Wallace L.J., Candlish D., et al. Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. J Biol Chem 278 (2003) 23502-23507
5. de Koning H.P., and Jarvis S.M. Hypoxanthine uptake through a purine-selective nucleobase transporter in Trypanosoma brucei brucei procyclic cells is driven by protonmotive force. Eur J Biochem 247 (1997) 1102-1110
6. Sanchez M.A., Drutman S., van Ampting M., Matthews K., and Landfear S.M. A novel purine nucleoside transporter whose expression is up-regulated in the short stumpy form of the Trypanosoma brucei life cycle. Mol Biochem Parasitol 136 (2004) 265-272
7. Al-Salabi M.I., Wallace L.J., Luescher A., et al. Molecular interactions underlying the unusually high adenosine affinity of a novel Trypanosoma brucei nucleoside transporter. Mol Pharmacol 71 3 (2007) 921-929
8. Le Ray D., Barry J.D., Easton C., and Vickerman K. First tsetse fly transmission of the "AnTat" serodeme of Trypanosoma brucei. Ann Soc Belg Med Trop 57 (1977) 369-381
9. Delauw M.F., Pays E., Steinert M., Aerts D., Van Meirvenne N., and Le Ray D. Inactivation and reactivation of a variant-specific antigen gene in cyclically transmitted Trypanosoma brucei. EMBO J 4 (1985) 989-993
10. Sanchez M.A., Tryon R., Green J., Boor I., and Landfear S.M. Six related nucleoside/nucleobase transporters from Trypanosoma brucei exhibit distinct biochemical functions. J Biol Chem 277 (2002) 21499-21504
11. Liniger M., Bodenmüller K., Pays E., Gallati S., and Roditi I. Overlapping sense and antisense transcription units in Trypanosoma brucei. Mol Microbiol 40 (2001) 869-878
12. Vassella E., Reuner B., Yutzy B., and Boshart M. Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway. J Cell Sci 110 Pt 21 (1997) 2661-2671
13. Vassella E., Den Abbeele J.V., Bütikofer P., et al. A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia. Genes Dev 14 (2000) 615-626
14. Vickerman K. Polymorphism and mitochondrial activity in sleeping sickness trypanosomes. Nature 208 (1965) 762-766
15. Geiser F., Lüscher A., de Koning H.P., Seebeck T., and Mäser P. Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited. Mol Pharmacol 68 3 (2005) 589-595
16. de Koning H.P., Anderson L.F., Stewart M., Burchmore R.J., Wallace L.J., and Barrett M.P. The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes. Antimicrob Agents Chemother 48 (2004) 1515-1519
17. Flück C., Salomone J.Y., Kurath U., and Roditi I. Cycloheximide-mediated accumulation of transcripts from a procyclin expression site depends on the intergenic region. Mol Biochem Parasitol 127 (2003) 93-97
18. Burkard G., Fragoso C.M., and Roditi I. Highly efficient stable transformation of bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol 153 2 (2007) 220-223
19. Domenicali Pfister D., Burkard G., Morand S., Kunz Renggli C., Roditi I., and Vassella E. A mitogen-activated protein kinase controls differentiation of bloodstream forms of Trypanosoma brucei. Eukaryot Cell 5 (2006) 1126-1135
20. de Koning H.P., Watson C.J., and Jarvis S.M. Characterization of a nucleoside/proton symporter in procyclic Trypanosoma brucei brucei. J Biol Chem 273 (1998) 9486-9494