Decrease in the activities of lysosomal enzymes may contribute to the urotoxicity of cyclophosphamide in the rat

Biomedical Research

Volumn 18, Issue 2, 2007, Pages 131-136

  Abraham, Premila ^a   Kanakasabapathy, Indirani ^a   Sugumar, Emila ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Cyclophosphamide; Lysosomal enzymes; Protein content; Rat; Urotoxicity

Indexed keywords

ACETYLGLUCOSAMINIDASE; ACID PHOSPHATASE; BETA GLUCURONIDASE; CYCLOPHOSPHAMIDE; LYSOSOME ENZYME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER INJURY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; HEMATURIA; HEMORRHAGIC CYSTITIS; HISTOPATHOLOGY; NONHUMAN; PROTEIN CONTENT; RAT;

RATTUS; RATTUS NORVEGICUS;

EID: 34249948814     PISSN: 0970938X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Frasier LU, Sarathchandra K, Kehrer JP. Cyclophosphamide toxicity: Characterising and avoiding the problem. Drugs 1991; 42: 781-795.
2. Grinberg-Funes D, Sheldon C, Weiss ?. The use of prostaglandin F2 for the prophylaxis of cyclophosphamide-induced cystitis in the rat. J Urol 1990; 44: 1500-1504.
3. Menetrey D, Bon K, Michiels JF, Lanteri-Minet M. The uroprotection of mesna on cyclophosphamide cystitis in rats. Its consequences on behaviour and brain activities. CR Acad Sci III 1999; 322:505-515.
4. Alferi AB and Cubeddu LX. La liberacion de oxido nitrico inducida por ciclofosfamida en la rata puede ser prevenida con un antagonista de los receptors NK1. Proceedings of the XV Congreso Latinoamericano de Farmacologia, VI Congreso Interamericando de Farmacologia Clinica y Terapeutica 1997: Cartagena de Indias, Colombia.
5. Alferi AB, Gardner CJ. The NKI antagonist, GR203-040, inhibits cyclophosphamide-induced damage in the rat and ferret bladder. Gen Pharmacol 1997; 29: 245-250.
6. Tokunaga H, Waguri S, Sato N, Ohsawa Y, Banya Y, Kominami E, Uchiyama Y. Lysosomal cysteine and aspartic proteinases and ubiquitin in rat and human urinary bladder epithelium. Arch Histol Cytol. 1996; 59: 249-260.
7. Themann H, Oberdorf E, Brock N, Pohl J. Electron microscopic investigations of the cyclophosphamide-induced lesions of the urinary bladder of the rat and their prevention by mesna. Urol Int. 1987;42: 37-43
8. Novikoff AB. Lysosomes and related particles. In the cell, vol 2 (ed.J Brachet & AE Mirsky), New York and London; Academic Press, 1961, pp 423-488.
9. Hicks RM. The function of the Golgi complex in transitional epithelium. Synthesis of the thick cell membrane. J Cell Biol 1966; 30: 623-643.
10. Kanzack NM, Krall JI, Hayes ER 1. Lysosomal fractions from transitional epithelium. J Cell Biol 1965; 24: 259-266.
11. Khandkar MA, Parmar DV. Is activation of lysosomal enzymes responsible for paracetamol induced hepatotoxicity and nephrotoxicity? J Pharm Pharmacol 1996; 48: 437-440.
12. Vengerovaski AI, Saratikov AS. The effect of hepatotoxins on the activity of organelle- specific enzymes and metabolism of liver lipids. Vopr Med Khim 1989; 35: 87-91.
13. Whiting PH, Brown PA. The relationship between enzymuria and kidney enzyme activities in experimental gentamicin toxicity. Ren Fail 1996; 18: 899-909.
14. Olbricht CJ, Fink M. Alterations in lysosomal enzymes of the proximal tubule in gentamicin neprotoxicity. Kidney Int 1991; 39: 639-646.
15. Dianzani MU. Lysosome changes in liver injury. In: Ciba Foundation Symposium on Lysosomes. Eds. A.V. S. deReuck and MP Cameron, Little, Brown and Co., Boston. 1963; 335-351
16. Younes M, Albrecht M, Siegers CP. Interrelation between lipid peroxidation and lysosomal enzyme release in the presence of carbon tetrachloride, cumene hydroperoxide or thioacetamide. J Appl Pharmacol 1983; 40: 121-132.
17. Ahluwalia A, Maggi CA, Santiccioli P, Lecci A, Giuliani S. Characterisation of the Capsaicin-sensitive component of cyclophosphamide- induced inflammation in the rat urinary Bladder. Br J Pharmacol 1994; 111: 1017-1022.
18. Abd-Allah AR, Gado IS, Al-Majed AAA, Al-Yahya AA, Al-Shabanah OA. Protective effect of taurine against cyclophosphamide-induced urinary bladder toxicity in rats. Clin Exp Pharmacol Physiol 2005; 32: 167-72.
19. Kyaw AA, Aung T, Htut T. Lysosomal enzymes activities in normals and in patients with chronic liver disease. Clin Chim Acta 1983; 131: 317-323.
20. Kawai Y, Anno K. Mucopolysaccharide-degrading enzymes from the liver of the squid, Ommastrephes sloami pacificus I. Hyaluronidase. Biochim Biophys Acta 1971; 242: 428-436.
21. Rosenblit PD, Metzger RP, Wick AN. Effect of streptozotocin diabetes on acid phosphatase and selected glycosidase activities of serum and various rat organs. Proc Soc Exp Biol Med 1974; 145: 244-248.
22. Lowry OH, Rosebrough MJ, Farr AL. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
23. DeDuveC, WattiauxR. Functions of lysosomes.Annu Rev Physiol. 1966;28: 435-439
24. Wakefield JJ, Hicks RM. Erythrophagocytosis by the epithelial cells of the bladder. J Cell Sci 1974; 15: 555-573.
25. Simon GT, Burke JS. Electron microscopy of the spleen. III. Erythro-leucophagocytosis. Am J Path 1970; 58: 451-470.
26. Marton PF. Erythrophagocytosis in the human bone marrow. Scand J Haemat 1970; 7: 177.
27. Edwards VD, Simon GT. Ultrastructural aspects of red cell destruction in the normal rat spleen. J Ultrastruct Res 1970; 33:187-201.
28. Grek OR, Mishenina SV, Pupyshev AB. Protective effect of enterosgel on rat liver lysosomes during cytostatic treatment. Bull Exp Biol Med. 2002; 134: 355-358.