Developments in pathogenesis and diagnosis of gastroesophageal reflux disease

Current Opinion in Gastroenterology

Volumn 23, Issue 4, 2007, Pages 428-433

  Karamanolis, George ^a   Sifrim, Daniel ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Extra esophageal manifestations; Gastroesophageal reflux disease; Impedance; Obesity; Transient lower esophageal sphincter relaxations

Indexed keywords

AUTONOMIC NERVOUS SYSTEM; DIAGNOSTIC PROCEDURE; ESOPHAGUS MOTILITY; GASTROESOPHAGEAL REFLUX; HIATUS HERNIA; HUMAN; LOWER ESOPHAGUS SPHINCTER; OBESITY; PATHOGENESIS; PATIENT MONITORING; REVIEW; RISK FACTOR;

AUTONOMIC NERVOUS SYSTEM; BILE REFLUX; COUGH; ELECTRIC IMPEDANCE; ESOPHAGEAL PH MONITORING; GASTROESOPHAGEAL REFLUX; HUMANS; LARYNGEAL NEOPLASMS; OBESITY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY ASPIRATION; STOMACH;

EID: 34249942804     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e328133f56a     Document Type: Review

References (43)

1. Fletcher J, Wirz A, Young J, et al. Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal. Gastroenterology 2001; 121:775-783.
2. Fletcher J, Wirz A, Henry E, et al. Studies of acid exposure immediately above the gastro-oesophageal squamocolumnar junction: evidence of short segment reflux. Gut 2004; 53:168-173.
3. Cameron AJ, Arora AS. Barrett's esophagus and reflux esophagitis: is there a missing link? Am J Gastroenterol 2002; 97:273-278.
4. Pandolfino JE, Lee TJ, Schreiner MA, et al. Comparison of esophageal acid exposure at 1cm and 6 cm above the squamocolumnar junction using the Bravo™ pH monitoring system. Dis Esophagus 2006; 19:177-182.
5. Wenner J, Johnsson F, Johansson J, Oberg S. Acid reflux immediately above the squamocolumnar junction and in the distal esophagus: simultaneous pH monitoring using the wireless capsule pH system. Am J Gastroenterol 2006; 101:1734-1741. This study shows that standard ph monitoring underestimates acid reflux occurring in the most distal esophagus and provides normal values in this region for future studies.
6. Dickman R, Bautista JM, Wong WM, et al. Comparison of esophageal acid exposure distribution along the esophagus among the different gastroesophageal reflux disease (GERD) groups. Am J Gastroenterol 2006; 101: 2463-2469.
7. Xu XR, Li ZS, Zou DW, et al. Role of duodenogastroesophageal reflux in the pathogenesis of esophageal mucosal injury and gastroesophageal reflux symptoms. Can J Gastroenterol 2006; 20:91-94.
8. Oh DS, Hagen JA, Fein M, et al. The impact of reflux composition on mucosal damage and esophageal function. J Gastrointest Surg 2006; 10:787-797.
9. Zebrib F, Roman S, Ropert A, et al. Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy. Am J Gastroenterol 2006; 101:1956-1963. This study demonstrates that adding impedance to pH monitoring improves the diagnostic yield mainly in patients on PPI.
10. Mainie I, Tutuain R, Shay S, et al. Acid and nonacid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut 2006; 55:1398-1402.
11. Penagini R, Hebbard G, Horowitz M, et al. Motor function of the proximal stomach and visceral perception in gastro-oesophageal reflux disease. Gut 1998; 42:251-257.
12. Iovino P, Angrisani L, Galloro G, et al. Proximal stomach function in obesity with normal and abnormal oesophageal acid exposure. Neurogastroenterol Motil 2006; 18:425-432.
13. Gonlachanvit S, Maurer AH, Fisher RS, Parkman HP. Regional gastric emptying abnormalities in functional dyspepsia and gastro-oesophageal reflux disease. Neurogastroenterol Motil 2006; 18:894-904.
14. Pandolfino JE, Ghosh SK, Zhang Q, et al. Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol 2006; 290:G1033-G1040.
15. Shafic A, Shafic I, El Sibai O, Mostafa RM. The effect of esophageal and gastric distension on the crural diaphragm. World J Surg 2006; 30:199-204.
16. Mittal RK, Holloway RH, Penagini R, et al. Transient lower esophageal sphincter relaxation. Gastroenterology 1995; 109:601-610.
17. Penagini R, Bianchi PA. Effect of morphine on gastroesophageal reflux and transient lower esophageal sphincter relaxation. Gastroenterology 1997; 113:409-414.
18. Bredenoord AJ, Weusten BLAM, Timmer R, Smout AJPM. Gastro-oesophageal reflux of liquids and gas during transient lower oesophageal sphincter relaxations. Neurogastroenterol Motil 2006; 18:888-893.
19. Pandolfino JE, Zhang Q, Ghosh SK, et al. Transient lower esophageal sphincter relaxation and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry. Gastroenterology 2006; 131:1725-1733. This is a mechanistic study which analyzes the mechanisms leading to esophagogastric junction opening during transient lower esophageal sphincter relaxations.
20. Bredenoord AJ, Weusten BLAM, Timmer R, Smout AJPM. Intermittent spatial separation of diaphragm and lower esophgeal sphincter favors acidic and weakly acidic reflux. Gastroenterology 2006; 130:334-340.
21. Emerenziani S, Habib FI, Ribolsi M, et al. Effect of hiatal hernia on proximal oesophageal acid clearance in gastro-oesophageal reflux disease patients. Aliment Pharmacol Ther 2006; 23:751-756.
22. Hamoui N, Lord RV, Hagen JA, et al. Response of the lower esophageal sphincter to gastric distention by carbonated beverages. J Gastrointest Surg 2006; 10:870-877.
23. Bredenoord AJ, Weusten BLAM, Timmer R, Smout AJPM. Air swallowing, belching, and reflux in patients with gastroesophageal reflux disease. Am J Gastroenterol 2006; 101:1721-1726.
24. Lee YC, Wang HP, Lin LY, et al. Circadian change of cardiac autonomic function in correlation with intra-esophageal pH. J Gastroenterol Hepatol 2006; 21:1302-1308.
25. Chen CL, Orr WC, Yang CC, Kuo TB. Cardiac autonomic regulation differentiates reflux disease with and without erosive esophagitis. Scand J Gastroenterol 2006; 41:1001-1006.
26. Lee KJ, Kim JH, Cho SW. Prevalence of ineffective esophageal motility and its relevance to symptoms and esophageal acid exposure in Korean patients referred for foregut symptoms. Digestion 2006; 73:171-177.
27. Quiroga E, Cuenca-Abente F, Flum D, et al. Impaired esophageal function in morbidly obese patients with gastroesophageal reflux disease: evaluation with multichannel intraluminal impedance. Surg Endosc 2006; 20:739-743. This study suggests that impedance is a more sensitive test than manometry in order to identify defective bolus transit in GERD patients.
28. Cicala M, Emerenziani S, Caviglia R, et al. Intra-oesophageal distribution and perception of acid reflux in patients with nonerosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2003; 18:605-613.
29. Bredenoord AJ, Weusten BLAM, Curvers WL, et al. Determinants of perception of heartburn and regurgitation. Gut 2006; 55:313-318.
30. Galmiche JP, Clouse RE, Balint A, et al. Functional esophageal disorders. Gastroenterology 2006; 130:1459-1465.
31. Bredenoord AJ, Weusten BLAM, Timmer R, Smout AJPM. Characteristics of gastroesophageal reflux in symptomatic patients with and without excessive esophageal acid exposure. Am J Gastroenterol 2006; 101:2470-2475. Using symptom association probability this study shows that symptoms in patients with normal pHmetry may be result from a combination of hypersensitivity and a higher proportion of reflux episodes extending to the proximal esophagus.
32. Jacobson BC, Somers SC, Fuchs CS, et al. Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 2006; 354:2340-2348. This large-scale study confirms an association between body mass index and reflux symptoms and shows that even moderate weight gain may exacerbate reflux symptoms.
33. Rey E, Moreno-Elola-Olaso C, Artalejo FR, et al. Association between weight gain and symptoms of gastroesophageal reflux in the general population. Am J Gastroenterol 2006; 101:229-233.
34. Cremonini F, Locke GR 3rd, Schleck CD, et al. Relationship between upper gastrointestinal symptoms and changes in body weight in a population-based cohort. Neurogastroenterol Motil 2006; 18:987-994.
35. Corley DA, Kubo A. Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis. Am J Gastroenterol 2006; 101:2619-2628.
36. Ortiz V, Ponce M, Fernandez A, et al. Value of heartburn for diagnosing gastroesophageal reflux disease in severely obese patients. Obesity 2006; 14:696-700.
37. Pandolfino JE, El-Serag HB, Zhang Q, et al. Obesity: a challenge to esophagastric junction integrity. Gastroenterology 2006; 130:639-649. This study using the newest modern manometric technology attempts to explain the association between obesity and gastroesophageal reflux.
38. Ravelli AM, Panarotto MB, Vendoni L, et al. Pulmonary aspiration shown by scintigraphy in gastroesophageal reflux-related respiratory disease. Chest 2006; 130:1520-1526.
39. Rascon-Aguilar IE, Pamer M, Wludyka P, et al. Role of gastroesophageal reflux symptoms in exacerbations of COPD. Chest 2006; 130:1096-1101.
40. Dibaise JK, Sharma VK. Does gastroesophageal reflux contribute to the development of chronic sinusitis? A review of the evidence. Dis Esophagus 2006; 19:419-424.
41. Vaezi MF, Qadeer MA, Lopez R, Colabianchi N. Laryngeal cancer and gastroesophageal reflux disease: a case-control study. Am J Med 2006; 119:768-776.
42. Andersson O, Ylitalo R, Finizia C, et al. Pharyngeal reflux episodes at ph 5 in healthy volunteers. Scand J Gastroenterol 2006; 41:138-143.
43. Tutuian R, Mainie I, Agrawal A, et al. Nonacid reflux in patients with chronic cough on acid suppressive therapy. Chest 2006; 130:386-391. This study shows that in patients with persistent cough despite PPI, positive symptom index during impedance-pHmetry is very helpful in selecting those who will benefit from antireflux surgery.