The common C49620T polymorphism in the sulfonylurea receptor gene (ABCC8), pancreatic beta cell function and long-term diabetic complications in obese patients with long-lasting type 2 diabetes mellitus

Experimental and Clinical Endocrinology and Diabetes

Volumn 115, Issue 5, 2007, Pages 317-321

  Stefanski, A ^a   Majkowska, L ^a   Ciechanowicz, A ^a   Frankow, M ^a   Safranow, K ^a   Parczewski, M ^a   Pilarska, K ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

cell function; ABCC8 gene polymorphism; Glucagon test; Type 2 diabetes

Indexed keywords

GLUCAGON; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; SULFONYLUREA RECEPTOR;

ABCC8 GENE; ADULT; AGED; ALLELE; ARTICLE; BODY MASS; CELL FUNCTION; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DNA POLYMORPHISM; EXON; FEMALE; GENOTYPE; GLUCAGON BLOOD LEVEL; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RECEPTOR GENE; STROKE;

AGED; ATP-BINDING CASSETTE TRANSPORTERS; CEREBROVASCULAR ACCIDENT; CHRONIC DISEASE; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCAGON; HUMANS; INJECTIONS, INTRAVENOUS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PREVALENCE; RECEPTORS, DRUG; TIME FACTORS;

EID: 34249939706     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-967086     Document Type: Article

References (16)

1. Albareda M, Rigla M, Rodriguez-Espinosa J, Caballero A, Chico A, Cabezas R, Carreras G, Perez A: Influence of exogenous insulin on C-peptide levels in subjects with type 2 diabetes. Diabetes Res Clin Pract 2005; 68: 202-206
2. Arner P, Pollare T, Lithell H: Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia 1991; 34: 483-487
3. Ashcroft FM: ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest 2005; 115: 2047-2058
4. Elbein SC, Sun J, Scroggin E, Teng K, Hasstedt SJ: Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes. Diabetes Care 2001; 24: 472-478
5. Hansen T, Echwald SM, Hansen L, Moller AM, Almind K, Clausen JO, Urhammer SA, Inoue H, Ferrer J, Bryan J, Aguilar-Bryan L, Permutt MA, Pedersen O: Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene. Diabetes 1998; 47: 598-605
6. Hart LM, de Knijff P, Dekker JM, Stolk RP, Nijpels G, van der Does FE, Ruige JB, Grobbee DE, Heine RJ, Maassen JA: Variants in the sulfonylurea receptor gene: association of the exon 16-3t variant with type II diabetes mellitus in Dutch Caucasians. Diabetologia 1999; 42: 617-620
7. Hart LM, Dekker JM, van Haeften TW, Ruige JB, Stehouwer CD, Erkelens DW, Heine RJ, Maassen JA: Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus. Diabetologia 2000; 43: 515-519
8. Holman R, Hines G, Kennedy I, Stevens R, Matthews D, Levy J: A calculator for HOMA. Diabetologia 2004; 47 (Suppl 1):A222
9. Inoue H, Ferrer J, Welling CM, Elbein SC, Hoffman M, Mayorga R, Warren-Perry M, Zhang Y, Millns H, Turner R, Province M, Bryan J, Permutt MA, Aguilar-Bryan L: Sequence variants in the sulfonylurea recepor (SUR) gene are associated with NIDDM in Caucasians. Diabetes 1996; 45: 825-831
10. Lahiri DK, Bye S, Nurnberger JI Jr, Hodes ME, Crisp M: A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods tested. J Biochem Biophys Methods 1992; 25: 193-205
11. Meirhaeghe A, Helbecque N, Cottel D, Arveiler D, Ruidavets JB, Haas B, Ferrieres J, Tauber JP, Bingham A, Amouyel P: Impact of sulfonylurea receptor 1 genetic variability on non-insulin-dependent diabetes mellitus prevalence and treatment: a population study. Am J Med Genet. 2001; 101: 4-8
12. Schneider S, Feilen PJ, Schreckenberger M, Schwanstecher M, Schwanstecher C, Buchholz HG, Thews O, Oberholzer K, Korobeynikov A, Bauman A, Comagic S, Piel M, Schirrmacher E, Shiue CY, Alavi AA, Bartenstein P, Rosch F, Weber MM, Klein HH, Schirrmacher R: In vitro and in vivo evaluation of novel glibenclamide derivatives as imaging agents for the non-invasive assessment of the pancreatic islet cell mass in animals and humans. Exp Clin Endocrinol Diabetes 2005; 113: 388-395
13. Wallace TM, Levy JC, Matthews DR: Use and abuse of HOMA modeling. Diabetes Care 2004; 27: 1487-1495
14. Weisnagel SJ, Rankinen T, Nadeau A, Rao DC, Chagnon YC, Perusse L, Bouchard C: Decreased Fasting and Oral Glucose Stimulated C-peptide in Nondiabetic Subjects With Sequence Variants in the Sulfonylurea Receptor 1 Gene. Diabetes 2001; 50: 697-702
15. Wright A, Burden AC, Paisey RB, Cull CA, Holman RR, U.K. Prospective Diabetes Study Group: Sulfonylurea inadequacy: efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.K. Prospective Diabetes Study (UKPDS 57). Diabetes Care 2002; 25: 330-336
16. Zychma MJ, Gumprecht J, Strojek K, Grzeszczak W, Moczulski D, Trautsolt W, Karasek D: Sulfonylurea receptor gene 16-3 polymorphism - association with sulfonylurea or insulin treatment in type 2 diabetic subjects. Med Sci Monit 2002; 8: CR512-515