Optimal design for multiresponse pharmacokinetic-pharmacodynamic models - Dealing with unbalanced designs

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 34, Issue 3, 2007, Pages 313-331

  Ogungbenro, Kayode ^a   Gueorguieva, Ivelina ^b   Majid, Oneeb ^a   Graham, Gordon ^c   Aarons, Leon ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ELI LILLY AND COMPANY   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

D optimality; Fixed effects; Mixed effects; Multiresponse; Nonlinear; Optimal design; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ARTICLE; DRUG BLOOD LEVEL; HEART RATE; MEAN ARTERIAL PRESSURE; NONLINEAR SYSTEM; PRIORITY JOURNAL; REGRESSION ANALYSIS; RESPONSE VARIABLE; SAMPLING; SIMULATION; STATISTICAL MODEL;

BLOOD PRESSURE; CARDIOVASCULAR AGENTS; COMPUTER SIMULATION; HEART RATE; HUMANS; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PHARMACOKINETICS; RESEARCH DESIGN;

EID: 34249912369     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-006-9048-7     Document Type: Article

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