Effects of exercise and oral antioxidant supplementation enriched in (n - 3) fatty acids on blood oxidant markers and erythrocyte membrane fluidity in horses

Veterinary Journal

Volumn 174, Issue 1, 2007, Pages 113-121

  De Moffarts, B ^a   Portier, K ^b   Kirschvink, N ^a   Coudert, J ^c   Fellmann, N ^c   van Erck, E ^a   Letellier, C ^d   Motta, C ^e   Pincemail, J ^a   Art, T ^a   Lekeux, P ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b VETAGRO SUP   (France)

^c UNIVERSITÉ CLERMONT AUVERGNE   (France)

^d SERVICE DE RHUMATOLOGIE   (France)

^e Biochemistry Laboratory   (France)

Author keywords

( 3)PUFA; Antioxidant; Exercise; Horses; Membrane fluidity

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID A PROTEIN; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; COPPER; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; LACTIC ACID; LIPID; LIPID PEROXIDE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; OXIDIZING AGENT; SELENIUM; SUPEROXIDE DISMUTASE; URIC ACID; WATER; ZINC;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROCYTE MEMBRANE; EXERCISE TEST; FEMALE; GELDING; HEART RATE; HORSE; MALE; MEMBRANE FLUIDITY; NONHUMAN; PROTEIN BLOOD LEVEL; REST; TREATMENT DURATION; VITAMIN SUPPLEMENTATION;

ANIMALS; ANTIOXIDANTS; DIETARY SUPPLEMENTS; ERYTHROCYTE MEMBRANE; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; HORSES; MALE; PHYSICAL CONDITIONING, ANIMAL;

EQUIDAE;

EID: 34249902060     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2006.06.001     Document Type: Article

References (39)

1. Benderitter M., Vincent-Genod L., Pouget J.P., and Voisin P. The cell membrane as a biosensor of oxidative stress induced by radiation exposure: a multiparameter investigation. Radiation Research 159 (2003) 471-483
2. Borst J.W., Visser N.V., Kouptsova O., and Visser A.J. Oxidation of unsaturated phospholipids in membrane bilayer mixtures is accompanied by membrane fluidity changes. Biochimica et Biophysica Acta 1487 (2000) 61-73
3. Calder P.C. n - 3 Fatty acids, inflammation, and immunity - relevance to post surgical and critically ill patients. Lipids 39 (2004) 1147-1161
4. Cazzola R., Russo-Volpe S., Cervato G., and Cestaro B. Biochemical assessments of oxidative stress, erythrocyte membrane fluidity and antioxidant status in professional soccer players and sedentary controls. European Journal of Clinical Investigation 33 (2003) 924-930
5. Cazzola R., Rondanelli M., Russo-Volpe S., Ferrari E., and Cestaro B. Decreased membrane fluidity and altered susceptibility to peroxidation and lipid composition in overweight and obese female erythrocytes. Journal of Lipid Research 45 (2004) 1846-1851
6. Clarkson P.M., and Thompson H.S. Antioxidants: what role do they play in physical activity and health?. American Journal of Clinical Nutrition 72 Suppl. 2 (2000) 637S-646S
7. Costabile M., Hii C.S., Melino M., Easton C., and Ferrante A. The immunomodulatory effects of novel beta-oxa, beta-thia, and gamma-thia polyunsaturated fatty acids on human T lymphocyte proliferation, cytokine production, and activation of protein kinase C and MAPKs. Journal of Immunology 174 (2005) 233-243
8. Crosby A.J., Wahle K.W.J., and Duthie G.G. Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 beta. Biochimica et Biophysica Acta 1303 (1996) 187-192
9. D'Aquino M., Benedetti P.C., Di Felice M., Gentili V., Tomassi G., Maiorino M., and Ursini F. Effect of fish oil and coconut oil on antioxidant defence system and lipid peroxidation in rat liver. Free Radical Biology and Medicine 1 (1991) 147-152
10. de Moffarts B., Kirschvink N., Art T., Pincemail J., Michaux C., Cayeux K., Defraigne J.O., and Lekeux P. Impact of training and exercise intensity on blood antioxidant markers in healthy Standardbred horses. Equine and Comparative Exercise Physiology 1 (2004) 211-220
11. de Moffarts B., Kirschvink N., Art T., Pincemail J., and Lekeux P. Effect of oral antioxidant supplementation on blood antioxidant status in trained thoroughbred horses. The Veterinary Journal 169 (2005) 65-74
12. Deaton C.M., Marlin D.J., Roberts C.A., Smith N., Harris P.A., Kelly F.J., and Schroter R.C. Antioxidant supplementation and pulmonary function at rest and exercise. Equine Veterinary Journal Supplements 34 (2002) 58-65
13. Drieu K., Vranckx R., Benassayad C., Haourigi M., Hassid J., Yoa R.G., Rapin J.R., and Nunez E.A. Effect of the extract of Ginkgo biloba (EGb 761) on the circulating and cellular profiles of polyunsaturated fatty acids: correlation with the anti-oxidant properties of the extract. Prostaglandins Leukotrienes and Essential Fatty Acids 63 (2000) 293-300
14. Hall J.A., Van Saun R.J., and Wander R.C. Dietary (n - 3) fatty acids from menhaden fish oil alter plasma fatty acids and leukotriene B synthesis in healthy horses. Journal of Veterinary Internal Medicine 18 (2004) 871-879
15. Hall J.A., Van Saun R.J., Tornquist S.J., Gradin J.L., Pearson E.G., and Wander R.C. Effect of type of dietary polyunsaturated fatty acid supplement (corn oil or fish oil) on immune responses in healthy horses. Journal of Veterinary Internal Medicine 18 (2004) 880-886
16. Hargreaves B.J., Kronfeld D.S., Waldron J.N., Lopes M.A., Gay L.S., Saker K.E., Cooper W.L., Sklan D.J., and Harris P.A. Antioxidant status and muscle cell leakage during endurance exercise. Equine Veterinary Journal Supplements 34 (2002) 116-121
17. Hildebrandt W., Alexander S., Bartsch P., and Droge W. Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O(2) chemosensitivity. Blood 99 (2002) 1552-1555
18. Hinchcliff K.W., Reinhart G.A., DiSilvestro R., Reynolds A., Blostein-Fujii A., and Swenson R.A. Oxidant stress in sled dogs subjected to repetitive endurance exercise. American Journal of Veterinary Research 61 (2000) 512-517
19. Hollan S. Membrane fluidity of blood cells. Haematologia (Budapest) 27 (1996) 109-127
20. Keddad K., Therond P., Motta C., Baussan C., and Legrand A. Alterations in erythrocyte membrane fluidity and fatty acid composition in glycogen storage disease. Biochimica et Biophysica Acta 1315 (1996) 61-65
21. Keith A.D., Sharnoff M., and Cohn G.E. A summary and evaluation of spin labels used as probes for biological membrane structure. Biochimica et Biophysica Acta 300 (1973) 379-419
22. Leibovitz B.E., Hu M.L., and Tappel A.L. Lipid peroxidation in rat tissue slices: effect of dietary Vit E, corn oil-lard and menhaden oil. Lipids 25 (1990) 125-129
23. Lemaître D., Vericel E., Polette A., and Lagarde M. Effects of fatty acids on human platelet glutathione peroxidase: possible role of oxidative stress. Biochemical Pharmacology 53 (1997) 479-486
24. Ma D.W., Seo J., Switzer K.C., Fan Y.Y., McMurray D.N., Lupton J.R., and Chapkin R.S. n - 3 PUFA and membrane microdomains: a new frontier in bioactive lipid research. Journal of Nutritional Biochemistry 15 (2004) 700-706
25. Marlin D.J., Fenn K., Smith N., Deaton C.D., Roberts C.A., Harris P.A., Dunster C., and Kelly F.J. Changes in circulatory antioxidant status in horses during prolonged exercise. Journal of Nutrition 132 Suppl. 2 (2002) 1622S-1627S
26. Mills P.C., Smith N.C., Casas I., Harris P., Harris R.C., and Marlin D.J. Effects of exercise intensity and environmental stress on indices of oxidative stress and iron homeostasis during exercise in the horse. European Journal of Applied Physiology and Occupational Physiology 74 (1996) 60-66
27. Mueller B.A., and Talbert R.L. Biological mechanisms and cardiovascular effects of omega-3 fatty acids. Clinical Pharmacology 7 (1988) 795-807
28. Nieman D.C. Immune response to heavy exertion. Journal of Applied Physiology 82 (1997) 1385-1394
29. O'Connor C.I., Lawrence L.M., Lawrence A.C., Janicki K.M., Warren L.K., and Hayes S. The effect of dietary fish oil supplementation on exercising horses. Journal of Animal Sciences 82 (2004) 2978-2984
30. Ochoa J.J., Vilchez M.J., Palacios M.A., Garcia J.J., Reiter R.J., and Munoz-Hoyos A. Melatonin protects against lipid peroxidation and membrane rigidity in erythrocytes from patients undergoing cardiopulmonary bypass surgery. Journal of Pineal Research 35 (2003) 104-108
31. Ojuawo A., and Keith L. The serum concentrations of zinc, copper and selenium in children with inflammatory bowel disease. Cent Africa Journal of Medicine 48 (2002) 116-119
32. O'Neill W., McKee S., and Clarke A.F. Flaxseed (Linum usitatissimum) supplementation associated with reduced skin test lesional area in horses with Culicoides hypersensitivity. Canadian Journal of Veterinary Research 66 (2002) 272-277
33. Palozza P., Sgarlata E., Luberto C., Piccioni E., Anti M., Marra G., Armelao F., Franceschelli P., and Bartoli G.M. N - 3 fatty acids induce oxidative modifications in human erythrocytes depending on dose and duration of dietary supplementation. American Journal of Clinical Nutrition 64 (1996) 297-304
34. Reznick A.Z., and Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods in Enzymology 233 (1994) 357-363
35. Schmidt E.B., Arnesen H., de Caterina R., Rasmussen L.H., and Kristensen S.D. Marine n - 3 polyunsaturated fatty acid and coronary disease. Thrombosis Research 115 (2005) 163-170
36. Sen C.K., and Packer L. Thiol homeostasis and supplements in physical exercise. American Journal of Clinical Nutrition 72 Suppl. 2 (2000) 653S-669S
37. Senturk U.K., Yalcin O., Gunduz F., Kuru O., Meiselman H.J., and Baskurt O.K. Effect of antioxidant vitamin supplement on the time course of hematological and hemorheological alterations after an exhausting exercise episode in human subjects. Journal of Applied Physiology 98 (2005) 1272-1279
38. Song J.H., Fujimoto K., and Miyazawa T. Polyunsaturated (n - 3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. Journal of Nutrition 130 (2000) 3028-3033
39. Venkatraman J.T., Chandrasekar B., Kim J.D., and Fernandes G. Effects of n - 3 and n - 6 fatty acids on the activities and expression of hepatic antioxidant enzymes in autoimmune-prone NZB × NZW F1 mice. Lipids 29 (1994) 561-568