Spontaneous regression of colorectal cancer: A review of cases from 1900 to 2005

International Journal of Colorectal Disease

Volumn 22, Issue 7, 2007, Pages 727-736

  Abdelrazeq, Ayman S ^a,b  

^a HUDDERSFIELD ROYAL INFIRMARY   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

Colorectal; Malignant; Neoplasm; Regression; Remission; Spontaneous

Indexed keywords

ANTIGEN; CANCER VACCINE; CARCINOGEN; CYTOKINE; GROWTH FACTOR; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CANCER IMMUNOTHERAPY; CANCER LOCALIZATION; CANCER RECURRENCE; CANCER REGRESSION; CANCER RISK; CANCER SURVIVAL; CLINICAL FEATURE; CLINICAL TRIAL; COLON BIOPSY; COLON CARCINOGENESIS; COLON RESECTION; COLORECTAL CANCER; COMPUTER ASSISTED TOMOGRAPHY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DEMOGRAPHY; FOLLOW UP; GENETIC RISK; HISTOPATHOLOGY; HUMAN; LIVER METASTASIS; MALIGNANT TRANSFORMATION; META ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOGENE; PERITONEUM METASTASIS; POSITRON EMISSION TOMOGRAPHY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; RISK MANAGEMENT; SEROLOGY; SURVIVAL TIME; SYSTEMATIC REVIEW;

COLORECTAL NEOPLASMS; HUMANS; INCIDENCE; NEOPLASM STAGING; PROGNOSIS; REMISSION, SPONTANEOUS; RETROSPECTIVE STUDIES; WORLD HEALTH;

EID: 34249894464     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-006-0245-z     Document Type: Review

References (112)

1. Kaiser HE, Bodey B Jr, Siegel SE, Groger AM, Bodey B (2000) Spontaneous neoplastic regression: The significance of apoptosis. In Vivo 14:773-788
2. Everson TC, Cole WH (1966) Spontaneous regression of cancer. WB Saunders, Philadelphia, PA
3. Boyd W (1966) The spontaneous regression of cancer. Charles C. Thomas, Springfield, IL
4. Cole WH (1974) Spontaneous regression of cancer: The metabolic triumph of the host? Ann N Y Acad Sci 230:111-141
5. Challis GB, Stam HJ (1990) The spontaneous regression of cancer. A review of cases from 1900 to 1987. Acta Oncol 29:545-550
6. O'Regan B, Hirschberg C (1993) Spontaneous remission. An annotated bibliography. Institute of Noetic Sciences, Sausalito, CA
7. Abdelrazeq AS, Lund JN, Leveson SH (2005) Spontaneous regression of peritoneal carcinomatosis from a rectal cancer. Eur J Gastroenterol Hepatol 17:1421-1423
8. Fergeson JO, Black BM (1954) Disappearance, probably spontaneous of locally inoperable carcinoma of the descending colon: Report of case. Mayo Clin Proc 29:407-410
9. Thomford NR, Black BM (1961) Presumably spontaneous cure of inoperable carcinoma of the colon; addendum to a report of a case in 1954. Mayo Clin Proc 36:504-506
10. Brunschwig A (1963) Spontaneous regression of cancer. Surgery 53:423-431
11. Mayo CW (1963) Tumor clinic conference. Cancer Bull 15:78-79
12. Brown CH (1961) Regression of metastatic lesions: Report of two cases. American Practice (Clinical Pediatrics) 12:655-656
13. Fullerton JM, Hill RD (1963) Spontaneous regression of cancer. Br Med J 21:1589-1590
14. Rankin GB, Brown CH, Crile G Jr (1965) Spontaneous regression of hepatic metastases from a carcinoma of the colon: 10-year follow up of a patient with familial polyposis. Ann Surg 162:156-159
15. Margolis J, West D (1967) Spontaneous regression of malignant disease: report of three cases. J Am Geriatr Soc 15:251-253
16. Synder W, Clark R, Rubini J (1968) Long-term survival of mother and son with widespread metastatic adenocarcinoma of colon. Cancer 21:129-133
17. Weinstock C (1977) Notes on "spontaneous" regression of cancer. J Am Soc Psychosom Dent Med 24:106-110
18. Meares A (1979) Regression of cancer of the rectum after intensive meditation. Med J Aust 2:539-540
19. Glasser M, Rosenberg MZ, Gaito R (1979) Widespread adenocarcinoma of the colon with survival of 28 years. JAMA 241:2542-2543
20. Beechey RT, Edwards BE, Kellands CH (1986) Adenocarcinoma of the colon: an unusual case. Med J Aust 144:211-213
21. Francis A, Temple JG, Hallissey MT (1997) Spontaneous resolution of histologically proven liver metastases from colorectal cancer. Br J Surg 84:818
22. Ikuta S, Miki C, Ookura E, Tonouchi H, Kusunoki M (2002) Spontaneous regression of a metastatic liver tumor: Report of a case. Surg Today 32:844-848
23. Van Langenberg A, Ong GB (1972) Carcinoma of large bowel in the young. Br Med J 3:374-376
24. Cohen AM, Minsky BD, Schilsky RL (1997) Cancer of the colon. In: Devita V Jr, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology, 5th edn. Lippincott-Raven, New York, pp 1144-1145
25. Davis SD, Koizumi J, Pitts WR (1989) Spontaneous regression of pulmonary metastases from renal cell carcinoma. Urology 13:141-144
26. Ogihara Y, Takeda K, Yanagawa T, Hirasawa Y (1994) Spontaneous regression of lung metastases from osteosarcoma. Cancer 74:2798-2803
27. Braren V, Taylor JN, Pace W (1974) Regression of metastatic renal carcinoma following nephrectomy. Urology 3:777-778
28. Dao TL (1962) Regression of pulmonary metastases of a breast cancer. Report of a case of spontaneous and temporary regression after radical mastectomy. Arch Surg 84:574-577
29. Gohji K, Kizaki T, Fujii A (1995) Spontaneous regression of pulmonary metastasis from nonfunctioning adrenocortical carcinoma after removal of the primary lesion: A case report. J Urol 154:1854-1855
30. MacManus MP, Harte RJ, Stranex S (1994) Spontaneous regression of metastatic renal cell carcinoma following palliative irradiation of the primary tumor. Ir J Med Sci 163:461-463
31. Punt CJ (2005) Chemotherapy of patients with colorectal carcinoma. Ned Tijdschr Geneeskd 149:1441-1447
32. Jemal A, Tiwari RC, Murray T et al (2004) Cancer statistics, 2004. CA Cancer J Clin 54:8-29
33. Forber J (1931) Incurable cancer: An investigation of hospital patients in eastern London. Rep Public Health Med Subj 66:1-59
34. Harnett WL (1953) The relation between delay in treatment of cancer and survival rate. Br J Cancer 7:19-36
35. Daland EM, Welch CE, Nathanson I (1936) One hundred untreated cancers of the rectum. N Engl J Med 214:451-458
36. Jerry LM, Challis EB (1984) Oncology. In: Rakel RE (ed) Textbook of family practice, 3rd edn. Saunders, Philadelphia, PA, pp 1061-1081
37. Franklin CI (1982) Spontaneous regression in cancer. In: Stoll BA (ed) Prolonged arrest of cancer. Wiley, Toronto, pp 103-116
38. Salloum E, Cooper DL, Howe G et al (1996) Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. J Clin Oncol 14:1943-1949
39. Penn I (1990) Cancers complicating organ transplantation. N Engl J Med 323:1767-1769
40. Viraben R, Brousse P, Lamant L (1996) Reversible cutaneous lymphoma occurring during methotrexate therapy. Br J Dermatol 130:116-118
41. Malkovska V, Sondel PM, Malkovsky M (1989) Tumor immunotherapy. Curr Opin Immunol 1:883-890
42. Nathanson L (1976) Spontaneous regression of malignant melanoma: A review of the literature on incidence, clinical features and possible mechanisms. Natl Cancer Inst Monogr 44:67-76
43. Stoll BA (1992) Spontaneous regression of cancer: New insights. Biotherapy 4:23-30
44. Dalerba P, Maccalli C, Casati C, Castelli C, Parmiani G (2003) Immunology and immunotherapy of colorectal cancer. Crit Rev Oncol Hematol 46:33-57
45. Serpick AA (1976) Spontaneous regression of colon carcinoma. Natl Cancer Inst Monogr 44:21
46. Papac RJ (1996) Spontaneous regression of cancer. Cancer Treat Rev 22:395-423
47. Balch CM, Riley LB, Bae YJ et al (1990) Patterns of human tumor-infiltrating lymphocytes in 120 human cancers. Arch Surg 125:200-205
48. Rosenberg SA (1992) Karnofsky memorial lecture. The immunotherapy and gene therapy of cancer. J Clin Oncol 10:180-199
49. Hawkins MJ, Atkins MB, Dutcher JP et al (1994) A phase II clinical trial of interleukin-2 and lymphokine-activated killer cells in advanced colorectal carcinoma. J Immunother 15:74-78
50. Greco FA, Figlin R, York M et al (1996) Phase III randomized study to compare interferon alfa-2a in combination with fluorouracil versus fluorouracil alone in patients with advanced colorectal cancer. J Clin Oncol 14:2674-2681
51. Wolmark N, Bryant J, Smith R et al (1998) Adjuvant 5-fluorouracil and leucovorin with or without interferon alfa-2a in colon carcinoma: National Surgical Adjuvant Breast and Bowel Project protocol C-05. J Natl Cancer Inst 90:1810-1816
52. Jass JR (1986) Lymphocytic infiltration and survival in rectal cancer. J Clin Pathol 36:585-589
53. Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma VM (1997) Prognostic value of tumor-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 182:318-324
54. Naito Y, Saito K, Shiiba K et al (1998) CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 58:3491-3494
55. Michael-Robinson JM, Biemer-Huttmann A, Purdie DM et al (2001) Tumor infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status. Gut 48:360-366
56. Miyagi Y, Imai N, Sasatomi T et al (2001) Induction of cellular immune responses to tumor cells and peptides in colorectal cancer patients by vaccination with SART3 peptides. Clin Cancer Res 7:3950-3962
57. Hanna MG Jr, Hoover HC Jr, Vemorken JB, Harris JE, Pinedo HM (2001) Adjuvant active specific immunotherapy of stage II and III colon cancer with an autologous tumor cell vaccine: First randomized phase III trials show promise. Vaccine 19:2576-2582
58. Alexander P (1976) Metastatic spread and "escape" from the immune defenses of the host. Natl Cancer Inst Monogr 44:125-129
59. Restifo NP, Kawakami Y, Marincola F et al (1993) Molecular mechanisms used by tumors to escape immune recognition: Immunogenetherapy and the cell biology of major histocompatibility complex class I. J Immunother 14:182-190
60. Garrido F, Algarra I (2001) MHC antigens and tumor escape from immune surveillance. Adv Cancer Res 83:117-158
61. Durrant LG, Ballantyne KC, Armitage NC et al (1987) Quantitation of MHC antigen expression on colorectal tumors and its association with tumor progression. Br J Cancer 56:425-432
62. Cabrera T, Collado A, Fernandez MA et al (1998) High frequency of altered HLA class I phenotypes in invasive colorectal carcinomas. Tissue Antigens 52:114-123
63. Sindelar WF (1976) Regression of cancer following surgery. Natl Cancer Inst Monogr 44:81-84
64. Parbhoo S (1982) Necrosis in cancer tissue. In: Stoll BA (ed) Prolonged arrest of cancer. Wiley, Chichester, pp 243-280
65. Weiss L, Holmes J (1980) Some effects of tumor necrosis on components of active cell movement. In: Strauli P (ed) Proteinases and tumor invasion. Raven, New York
66. Lefrere F, Hermine O, Radford-Weiss I et al (1994) A spontaneous remission of lymphoid blast crisis in chronic myelogenous leukaemia following blood transfusion and infection. Br J Haematol 88:621-622
67. Tucker J, Murphy MF, Gregory WM et al (1989) Apparent removal of graft-versus-leukaemia effect by the use of leucocyte-poor blood components in patients with acute myeloblastic leukaemia. Br J Haematol 73:572-574
68. Nauts HC, Swift WE, Coley BL (1946) The treatment of malignant tumors by bacterial toxins, as developed by the late William B. Coley, M.D., reviewed in the light of modern research. Cancer Res 6:205-216
69. Balkwill FR, Naylor MS, Malik S (1990) Tumour necrosis factor as an anticancer agent. Eur J Cancer 26:641-644
70. Stephenson HE Jr, Delmez JA, Renden DI et al (1971) Host immunity and spontaneous regression of cancer evaluated by computerized data reduction study. Surg Gynecol Obstet 133:649-655
71. Takita H (1970) Effect of postoperative empyema on survival of patients with bronchogenic carcinoma. J Thorac Cardiovasc Surg 59:642-668
72. Alexander P (1976) Some immunologically based reactions that can cause the regression of large tumour mass. Natl Cancer Inst Monogr 44:105-108
73. Folkman J (1990) What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82:4-6
74. Broder S, Karp JE (1995) Progress against cancer. J Cancer Res Clin Oncol 121:633-647
75. Jimemez C, Ribera JM, Abad E et al (1993) Increased serum tumour necrosis factor during transient remission in acute leukaemia. Lancet 341:1600
76. Greenwald P (1997) Dietary carcinogens. In: Devita VT Jr, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology. Lippincott-Raven, Philadelphia, pp 579-584
77. Modan B (1977) Dietary role in cancer etiology. Cancer 40:1887-1891
78. Willett NC, MacMahon B (1984) Diet and cancer: An overview (second of two parts). N Engl J Med 310:697-703
79. Harford FJ, Fazio VW, Epstein LM, Hewitt CB (1984) Rectosigmoid carcinoma occurring after ureterosigmoidostomy. Dis Colon Rectum 27:321-324
80. Hussell T, Isaacson PG, Crabtree JE, Spencer J (1993) The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 342:571-574
81. Cole WH (1981) Efforts to explain spontaneous regression of cancer. J Surg Oncol 17:201-209
82. Vujanovic NL (2001) Role of TNF family ligands in antitumour activity of natural killer cells. Int Rev Immunol 20:415-437
83. O'Reilly MS, Holmgren L, Chen C, Folkman J (1996) Angiostatin induced and sustained dormancy of human primary tumors in mice. Nat Med 2:689-692
84. Markowitz S, Wang J, Myeroff L et al (1995) Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268:1336-1338
85. Papac RJ (1998) Spontaneous regression of cancer: Possible mechanisms. In Vivo 12:571-578
86. Tocci G, Conte A, Guarascio P, Visco G (1990) Spontaneous remission of hepatocellular carcinoma after massive gastrointestinal haemorrhage. BMJ 300:641-642
87. Bos SD, Mensink HJ (1996) Spontaneous caval tumour thrombus necrosis and regression of pulmonary lesions in renal cell cancer. Scand J Urol Nephrol 30:489-492
88. Markovic S, Ferlan-Marolt V, Hlebanja Z (1995) Spontaneous regression of hepatacellular carcinoma. Am J Gastroenterol 91:392-393
89. Wyllie AH (1997) Apoptosis: An overview. Br Med Bull 53:451-465
90. Peter ME, Heufelder AE, Hengartner MO (1997) Advances in apoptosis research. Proc Natl Acad Sci USA 94:12736-12737
91. Kaufmann Y, Many A, Rechavi G et al (1995) Brief report: Lymphoma with recurrent cycles of spontaneous remission and relapse - possible role of apoptosis. N Engl J Med 332:507-510
92. Hoehner JC, Gestblom C, Olsen L, Pahlman S (1997) Spatial association of apoptosis-related gene expression and cellular death in clinical neuroblastoma. Br J Cancer 75:1185-1194
93. Pansera F (1992) Regression in renal carcinoma as re-expression of cell death in kidney development. Perspect Biol Med 35:416-421
94. Teraishi F, Wu S, Zhang L et al (2005) Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells. Cancer Res 65:6380-6387
95. Miquel C, Borrini F, Grandjouan S et al (2005) Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability. Am J Clin Pathol 123:562-570
96. Daouphars M, Koufany M, Benani A et al (2005) Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells. Int J Oncol 26:1069-1077
97. Din FV, Stark LA, Dunlop MG (2005) Aspirin-induced nuclear translocation of NFkappaB and apoptosis in colorectal cancer is independent of p53 status and DNA mismatch repair proficiency. Br J Cancer 92:1137-1143
98. Konishi T, Sasaki S, Watanabe T, Kitayama J, Nagawa H (2005) Over expression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells. Molecular Cancer Therapeutics 4:743-750
99. Schmutte C, Yang AS, Nguyen TT, Beart RW, Jones PA (1996) Mechanisms for the involvement of DNA methylation in colon carcinogenesis. Cancer Res 56:2375-2381
100. Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M (1988) Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 48:1159-1161
101. Schmid M, Haaf T, Grunert D (1984) 5-Azacytidine-induced undercondensations in human chromosomes. Hum Genet 67:257-263
102. Herman JG, Merlo A, Mao L et al (1995) Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55:4525-4530
103. Greger V, Passarge E, Hopping W, Messmer E, Horsthemke B (1989) Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet 83:155-158
104. Kim NW (1997) Clinical implications of telomerase in cancer. Eur J Cancer 33:781-786
105. Hiyama E, Hiyama K, Yokoyama K et al (1995) Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med 1:249-255
106. Meares A (1983) Psychological mechanisms in the regression of cancer. Med J Aust 1:583-584
107. Weinstock C (1984). Further evidence on psychobiological aspects of cancer. Int J Psychosom 31:20-22
108. Mahrer AR (1980) The treatment of cancer through experiential psychotherapy. Psychotherapy: Theory, Research and Practice 17:335-342
109. Levy S, Herberman R, Lippman M, d'Angelo T (1987) Correlation of stress factors with sustained depression of natural killer cell activity and predicted prognosis in patients with breast cancer. J Clin Oncol 5:348-353
110. Ader R, Cohen N (1985) CNS-immune system instruction: Conditioning phenomenon. Behav Brain Sci 8:379-394
111. Simonton OC, Matthews-Simonton S, Sparks TF (1980) Psychological intervention in the treatment of cancer. Psychosomatics 21:226-227, 231-233
112. Osler W (1901) The medical aspect of carcinoma of the breast, with a note on the spontaneous disappearance of secondary growths. Am Med 13:63-66