메뉴 건너뛰기




Volumn 2, Issue 1, 2007, Pages 3-12

Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer: Results and open issues

Author keywords

EGFR; NSCLC; Prognostic and predictive factors; Targeted therapies; TK inhibitors

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 34249889302     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-007-0002-5     Document Type: Article
Times cited : (14)

References (58)
  • 2
    • 1342268525 scopus 로고    scopus 로고
    • American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: Update 2003
    • Pfister DG, Johnson DH, Azzoli CG et al (2004) American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol 22:330-353
    • (2004) J Clin Oncol , vol.22 , pp. 330-353
    • Pfister, D.G.1    Johnson, D.H.2    Azzoli, C.G.3
  • 3
    • 0034777482 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is con-elated with survival
    • Brabender J, Danenberg KD, Metzger R et al (2001) Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is con-elated with survival. Clin Cancer Res 7:1850-1855
    • (2001) Clin Cancer Res , vol.7 , pp. 1850-1855
    • Brabender, J.1    Danenberg, K.D.2    Metzger, R.3
  • 5
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
    • Fukuoka M, Yano S, Giaccone G et al (2003) Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 21:2237-2246
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 6
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS et al (2003) Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 290:2149-2158
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 7
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small cell lung cancer: A phase III trial INTACT-1
    • Giaccone G, Herbst RS, Manegold C et al (2004) Gefitinib in combination with gemcitabine and cisplatin in advanced non-small cell lung cancer: a phase III trial INTACT-1. J Clin Oncol 22:777-784
    • (2004) J Clin Oncol , vol.22 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 8
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small cell lung cancer: A phase III trial INTACT-2
    • Herbst RS, Giaccone G, Schiller JH et al (2004) Gefitinib in combination with paclitaxel and carboplatin in advanced non-small cell lung cancer: a phase III trial INTACT-2. J Clin Oncol 22:785-794
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 9
    • 12744255161 scopus 로고    scopus 로고
    • Phase n clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non-small-cell lung cancer
    • Perez-Soler R (2004) Phase n clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non-small-cell lung cancer. Clin Lung Cancer 6[Suppl 1]:S20-S23
    • (2004) Clin Lung Cancer , vol.6 , Issue.SUPPL. 1
    • Perez-Soler, R.1
  • 10
    • 4444238981 scopus 로고    scopus 로고
    • Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC) [abstract]
    • abstr 7010
    • Gatzemeier U, Pluzanska A, Szczesna A et al (2004) Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC) [abstract]. ASCO meeting abstracts 22:617 (abstr 7010)
    • (2004) ASCO meeting abstracts , vol.22 , pp. 617
    • Gatzemeier, U.1    Pluzanska, A.2    Szczesna, A.3
  • 11
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst RS, Prager D, Hermann R et al (2005) TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 23:5892-5899
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 12
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al (2005) Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353:123-132
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 13
    • 21744449959 scopus 로고    scopus 로고
    • Gefitinib in non-small cell lung cancer
    • Tamura K, Fukuoka M (2005) Gefitinib in non-small cell lung cancer. Expert Opin Pharmacother 6:985-993
    • (2005) Expert Opin Pharmacother , vol.6 , pp. 985-993
    • Tamura, K.1    Fukuoka, M.2
  • 14
    • 26444519872 scopus 로고    scopus 로고
    • Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa)
    • Siegel-Lakhai WS, Beijnen JH, Schellens JH (2005) Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa). Oncologist 10:579-589
    • (2005) Oncologist , vol.10 , pp. 579-589
    • Siegel-Lakhai, W.S.1    Beijnen, J.H.2    Schellens, J.H.3
  • 15
    • 1842509828 scopus 로고    scopus 로고
    • Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer
    • Miller VA, Kris MG, Shah N et al (2004) Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. J Clin Oncol 22:1103-1109
    • (2004) J Clin Oncol , vol.22 , pp. 1103-1109
    • Miller, V.A.1    Kris, M.G.2    Shah, N.3
  • 16
    • 19844362355 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer
    • Giaccone G (2005) Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer. J Clin Oncol 23:3235-3242
    • (2005) J Clin Oncol , vol.23 , pp. 3235-3242
    • Giaccone, G.1
  • 17
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC et al (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304:1497-1500
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 18
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R et al (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 19
    • 4444344330 scopus 로고    scopus 로고
    • EOF receptor gene mutations are common in lung cancers from never smokers and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M et al (2004) EOF receptor gene mutations are common in lung cancers from «never smokers» and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 101:13306-13311
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 20
    • 33644545057 scopus 로고    scopus 로고
    • Mutations of epidermal growth factor receptor of non-small cell lung cancer were associated with sensitivity to gefitinib in recurrence after surgery
    • Kondo M, Yokoyama T, Fukui T et al (2005) Mutations of epidermal growth factor receptor of non-small cell lung cancer were associated with sensitivity to gefitinib in recurrence after surgery. Lung Cancer 50:385-391
    • (2005) Lung Cancer , vol.50 , pp. 385-391
    • Kondo, M.1    Yokoyama, T.2    Fukui, T.3
  • 21
    • 24744438887 scopus 로고    scopus 로고
    • Mutations in the tyrosine kinase domain of the EGFR gene associated with gefitinib response in non-small-cell lung cancer
    • Rosell R, Ichinose Y, Taron M et al (2005) Mutations in the tyrosine kinase domain of the EGFR gene associated with gefitinib response in non-small-cell lung cancer. Lung Cancer 50:25-33
    • (2005) Lung Cancer , vol.50 , pp. 25-33
    • Rosell, R.1    Ichinose, Y.2    Taron, M.3
  • 22
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    • Taron M, Ichinose Y, Rosell R et al (2005) Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin Cancer Res 11:5878-5885
    • (2005) Clin Cancer Res , vol.11 , pp. 5878-5885
    • Taron, M.1    Ichinose, Y.2    Rosell, R.3
  • 23
    • 20244388126 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    • Mitsudomi T, Kosaka T, Endoh H et al (2005) Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol 23:2513-2520
    • (2005) J Clin Oncol , vol.23 , pp. 2513-2520
    • Mitsudomi, T.1    Kosaka, T.2    Endoh, H.3
  • 24
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • Takano T, Ohe Y, Sakamoto H et al (2005) Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol 23:6829-6837
    • (2005) J Clin Oncol , vol.23 , pp. 6829-6837
    • Takano, T.1    Ohe, Y.2    Sakamoto, H.3
  • 25
    • 20244389188 scopus 로고    scopus 로고
    • Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib
    • Han S, Kim T, Hwang PG et al (2005) Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. J Clin Oncol 23:2493-2501
    • (2005) J Clin Oncol , vol.23 , pp. 2493-2501
    • Han, S.1    Kim, T.2    Hwang, P.G.3
  • 26
    • 28844449401 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: Molecular analysis of the IDEAL/INTACT gefitinib trials
    • Bell DW, Lynch TJ, Haserlat SM et al (2005) Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol 23:8081-8092
    • (2005) J Clin Oncol , vol.23 , pp. 8081-8092
    • Bell, D.W.1    Lynch, T.J.2    Haserlat, S.M.3
  • 27
    • 26444459867 scopus 로고    scopus 로고
    • Clinicopathologic significance of the mutations of the epidermal growth factor receptor gene in patients with non-small-cell lung cancer
    • Tomizawa Y, Iijima H, Sunaga N et al (2005) Clinicopathologic significance of the mutations of the epidermal growth factor receptor gene in patients with non-small-cell lung cancer. Clin Cancer Res 11:6816-6822
    • (2005) Clin Cancer Res , vol.11 , pp. 6816-6822
    • Tomizawa, Y.1    Iijima, H.2    Sunaga, N.3
  • 28
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC et al (2005) Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23:5900-5909
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3
  • 29
    • 32944481596 scopus 로고    scopus 로고
    • Clinical course of patients with non-small-cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
    • Riely GJ, Pao W, Pham D et al (2006) Clinical course of patients with non-small-cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 12:839-844
    • (2006) Clin Cancer Res , vol.12 , pp. 839-844
    • Riely, G.J.1    Pao, W.2    Pham, D.3
  • 30
    • 28844501639 scopus 로고    scopus 로고
    • Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
    • Shigematsu H, Gazdar AF (2006) Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer 118:257-262
    • (2006) Int J Cancer , vol.118 , pp. 257-262
    • Shigematsu, H.1    Gazdar, A.F.2
  • 31
    • 20044364933 scopus 로고    scopus 로고
    • EGFR mutations in non-small-cell lung cancer: Analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
    • Marchetti A, Martella C, Felicioni L et al (2005) EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol 23:857-865
    • (2005) J Clin Oncol , vol.23 , pp. 857-865
    • Marchetti, A.1    Martella, C.2    Felicioni, L.3
  • 32
    • 31544459265 scopus 로고    scopus 로고
    • Detection of EGFR gene mutation in lung cancer by mutant-enriched polymerase chain reaction assay
    • Asano H, Toyooka S, Tokumo M et al (2006) Detection of EGFR gene mutation in lung cancer by mutant-enriched polymerase chain reaction assay. Clin Cancer Res 12:43-48
    • (2006) Clin Cancer Res , vol.12 , pp. 43-48
    • Asano, H.1    Toyooka, S.2    Tokumo, M.3
  • 33
    • 32944468710 scopus 로고    scopus 로고
    • A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening
    • Janne PA, Borras AM, Kuang Y et al (2006) A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening. Clin Cancer Res 12:751-758
    • (2006) Clin Cancer Res , vol.12 , pp. 751-758
    • Janne, P.A.1    Borras, A.M.2    Kuang, Y.3
  • 34
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch FR, Varella-Garcia M, Bunn PA Jr et al (2003) Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 21:3798-3807
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr, P.A.3
  • 35
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F, Hirsch FR, Rossi E et al (2005) Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 97:643-655
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3
  • 36
    • 33644539850 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay
    • Endo K, Konishi A, Sasaki H et al (2005) Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay. Lung Cancer 50:375-384
    • (2005) Lung Cancer , vol.50 , pp. 375-384
    • Endo, K.1    Konishi, A.2    Sasaki, H.3
  • 37
    • 27244444360 scopus 로고    scopus 로고
    • Selecting patients for epidermal growth factor receptor inhibitor treatment: A FISH story or a tale of mutations?
    • Johnson BE, Janne PA (2005) Selecting patients for epidermal growth factor receptor inhibitor treatment: a FISH story or a tale of mutations? J Clin Oncol 23:6813-6816
    • (2005) J Clin Oncol , vol.23 , pp. 6813-6816
    • Johnson, B.E.1    Janne, P.A.2
  • 38
    • 4444332925 scopus 로고    scopus 로고
    • Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
    • Cappuzzo F, Magrini E, Ceresoli CL et al (2004) Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 96:1133-1141
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1133-1141
    • Cappuzzo, F.1    Magrini, E.2    Ceresoli, C.L.3
  • 39
    • 0035883542 scopus 로고    scopus 로고
    • Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung
    • Ahrendt SA, Decker PA, Alawi EA et al (2001) Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. Cancer 92:1525-1530
    • (2001) Cancer , vol.92 , pp. 1525-1530
    • Ahrendt, S.A.1    Decker, P.A.2    Alawi, E.A.3
  • 40
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T et al (2005) Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97:339-346
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 41
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • Pao W, Wang TY, Riely GJ et al (2005) KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2:e17
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3
  • 42
    • 33646791858 scopus 로고    scopus 로고
    • Uncommon V599E BRAF mutations in Japanese patients with lung cancer
    • Sasaki H, Kawano O, Endo K et al (2006) Uncommon V599E BRAF mutations in Japanese patients with lung cancer. J Surg Res 133:203-206
    • (2006) J Surg Res , vol.133 , pp. 203-206
    • Sasaki, H.1    Kawano, O.2    Endo, K.3
  • 43
    • 0036894746 scopus 로고    scopus 로고
    • BRAF and RAS mutations in human lung cancer and melanoma
    • Brose MS, Volpe P, Feldman M et al (2002) BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res 62:6997-7000
    • (2002) Cancer Res , vol.62 , pp. 6997-7000
    • Brose, M.S.1    Volpe, P.2    Feldman, M.3
  • 44
    • 32944468706 scopus 로고    scopus 로고
    • Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers
    • Toyooka S, Tokumo M, Shigematsu H et al (2006) Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers. Cancer Res 66:1371-1375
    • (2006) Cancer Res , vol.66 , pp. 1371-1375
    • Toyooka, S.1    Tokumo, M.2    Shigematsu, H.3
  • 45
    • 24344435084 scopus 로고    scopus 로고
    • Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: Its association with clinicopathologic features
    • Shibata T, Uryu S, Kokubu A et al (2005) Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res 11:6177-6185
    • (2005) Clin Cancer Res , vol.11 , pp. 6177-6185
    • Shibata, T.1    Uryu, S.2    Kokubu, A.3
  • 46
    • 27944444486 scopus 로고    scopus 로고
    • Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells
    • Janmaat ML, Rodriguez JA, Gallegos-Ruiz M, Kruyt FA, Giaccone G (2006) Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells. Int J Cancer 118:209-214
    • (2006) Int J Cancer , vol.118 , pp. 209-214
    • Janmaat, M.L.1    Rodriguez, J.A.2    Gallegos-Ruiz, M.3    Kruyt, F.A.4    Giaccone, G.5
  • 47
    • 24644445676 scopus 로고    scopus 로고
    • Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small cell lung cancer patients
    • Cappuzzo F, Varella-Garcia M, Shigematsu H et al (2005) Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small cell lung cancer patients. J Clin Oncol 23:5007-5018
    • (2005) J Clin Oncol , vol.23 , pp. 5007-5018
    • Cappuzzo, F.1    Varella-Garcia, M.2    Shigematsu, H.3
  • 48
    • 26644465742 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression status in lung cancer correlates with its mutation
    • Suzuki M, Shigematsu H, Hiroshima K et al (2005) Epidermal growth factor receptor expression status in lung cancer correlates with its mutation. Hum Pathol 36:1127-1134
    • (2005) Hum Pathol , vol.36 , pp. 1127-1134
    • Suzuki, M.1    Shigematsu, H.2    Hiroshima, K.3
  • 49
    • 28644444702 scopus 로고    scopus 로고
    • HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients
    • Cappuzzo F, Toschi L, Domenichini I et al (2005) HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients. Br J Cancer 93:1334-1340
    • (2005) Br J Cancer , vol.93 , pp. 1334-1340
    • Cappuzzo, F.1    Toschi, L.2    Domenichini, I.3
  • 50
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA et al (2005) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2:e73
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 51
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S, Boggon TJ, Dayaram T et al (2005) EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 352:786-792
    • (2005) N Engl J Med , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 52
    • 23844444080 scopus 로고    scopus 로고
    • An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor
    • Kobayashi S, Ji H, Yuza Y et al (2005) An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor. Cancer Res 65:7096-7101
    • (2005) Cancer Res , vol.65 , pp. 7096-7101
    • Kobayashi, S.1    Ji, H.2    Yuza, Y.3
  • 53
    • 33144464795 scopus 로고    scopus 로고
    • EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib
    • Yoshimura N, Kudoh S, Kimura T et al (2006) EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. Lung Cancer 51:363-368
    • (2006) Lung Cancer , vol.51 , pp. 363-368
    • Yoshimura, N.1    Kudoh, S.2    Kimura, T.3
  • 54
    • 29344450601 scopus 로고    scopus 로고
    • Enhancement of sensitivity of tumor necrosis factor alpha in non-small cell lung cancer cells with acquired resistance to gefitinib
    • Ando K, Ohmori T, Inoue F et al (2005) Enhancement of sensitivity of tumor necrosis factor alpha in non-small cell lung cancer cells with acquired resistance to gefitinib. Clin Cancer Res 11:8872-8879
    • (2005) Clin Cancer Res , vol.11 , pp. 8872-8879
    • Ando, K.1    Ohmori, T.2    Inoue, F.3
  • 55
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY et al (2004) Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305:399-401
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3
  • 56
    • 33644698120 scopus 로고    scopus 로고
    • First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer
    • Lange T, Muller-Tidow C, Serve H et al (2005) First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer. One Rep 14:1539-1542
    • (2005) One Rep , vol.14 , pp. 1539-1542
    • Lange, T.1    Muller-Tidow, C.2    Serve, H.3
  • 57
    • 17144385106 scopus 로고    scopus 로고
    • Gefitinib as a first-line therapy of advanced or metastatic adenocarcinoma of the lung in never-smokers
    • Lee DH, Han JY, Lee HG et al (2005) Gefitinib as a first-line therapy of advanced or metastatic adenocarcinoma of the lung in never-smokers. Clin Cancer Res 11:3032-3037
    • (2005) Clin Cancer Res , vol.11 , pp. 3032-3037
    • Lee, D.H.1    Han, J.Y.2    Lee, H.G.3
  • 58
    • 33644845421 scopus 로고    scopus 로고
    • First-line single agent treatment with gefitinib in patients with advanced non-small cell lung cancer: A phase II study
    • Niho S, Kubota K, Goto K et al (2006) First-line single agent treatment with gefitinib in patients with advanced non-small cell lung cancer: a phase II study. J Clin Oncol 24:64-69
    • (2006) J Clin Oncol , vol.24 , pp. 64-69
    • Niho, S.1    Kubota, K.2    Goto, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.