Infant apnea and gastroesophageal reflux: A critical review and framework for further investigation

Current Gastroenterology Reports

Volumn 9, Issue 3, 2007, Pages 219-224

  Slocum, Christopher ^b   Hibbs, Anna Maria ^b   Martin, Richard J ^a   Orenstein, Susan R ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID;

CHEMORECEPTOR REFLEX; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ECHOGRAPHY; ELECTROSTIMULATION; ESOPHAGEAL PH MONITORING; ESOPHAGUS SCINTISCANNING; FIBERSCOPE ENDOSCOPY; GASTROESOPHAGEAL REFLUX; HUMAN; INFANT; LARYNX MUSCLE; LOWER ESOPHAGUS SPHINCTER; NEWBORN APNEA; NEWBORN MONITORING; NONHUMAN; OUTCOME VARIABLE; PNEUMOTACHYGRAPHY; PREMATURITY; RESPIRATION CONTROL; RESPIRATION DEPRESSION; REVIEW; SENSORY STIMULATION; STOMACH EMPTYING;

APNEA; ESOPHAGEAL SPHINCTER, LOWER; GASTROESOPHAGEAL REFLUX; HUMANS; INFANT; INFANT, NEWBORN; INFANT, PREMATURE, DISEASES; LARYNX; MONITORING, AMBULATORY; RESEARCH DESIGN;

EID: 34249884520     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-007-0022-3     Document Type: Review

References (47)

1. Herbst JJ, Minton SD, Book LS: Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. J Pediatr 1979, 95:763-768.
2. Leape LL, Holder TM, Franklin JD, et al.: Respiratory arrest in infants secondary to gastroesophageal reflux. Pediatrics 1977, 60:924-928.
3. Fuloria M, Hiatt D, Dillard RG, O'Shea TM: Gastroesophageal reflux in very low birth weight infants: association with chronic lung disease and outcomes through 1 year of age. J Perinatol 2000, 20:235-239.
4. Spitzer AR, Boyle JT, Tuchman DN, Fox WW: Awake apnea associated with gastroesophageal reflux: A specific clinical syndrome. J Pediatr 1984, 104:200-205.
5. Menon AP, Schefft GL, Thach BT: Apnea associated with regurgitation in infants. J Pediatr 1985, 106:625-629
6. Harris P, Munoz C, Mobarec S, et al.: Relevance of the pH probe in sleep study analysis in infants. J Pediatr 2004, 30:337-344.
7. Peter CS, Sprodowski N, Bohnhorst B, et al.: Gastroesophageal reflux and apnea of prematurity: No temporal relationship. Pediatrics 2002, 109:8-11.
8. Mousa H, Woodley FW, Metheney M, Hayes J: Testing the association between gastroesophageal reflux and apnea in infants. J Pediatr Gastroenterol Nutr 2005, 41:169-177.
9. Wenzl TG, Schenke S, Peschgens T, et al.: Association of apnea and nonacid gastroesophageal reflux in infants: Investigations with the intraluminal impedance technique. Pediatr Pulmonol 2001, 31:144-149.
10. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR: Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 2006, 117:1979-1987.
11. Malcolm W, Gantz M, Das A, et al.: Anti-reflux medications (ARM) at NICU discharge for extremely low birthweight (ELBW) infants. Presented at the Academic Society for Pediatric Research. San Francisco, CA. April 2006.
12. Vandeplas Y, Sacre-Smits L: Continuous 24-hour esophageal pH monitoring in 285 asymptomatic infants 0-15 months old. J Pediatr Gastroenterol Nutr 1987, 6:220-224.
13. Lopez-Alonso M, Moya MJ, Cabo JA, et al.: Twenty-four-hour esophageal impedance-pH monitoring in healthy preterm neonates: rate and characteristics of acid, weakly acidic, and weakly alkaline gastroesophageal reflux. Pediatrics 2006, 118:e299-e308.
14. Orenstein SR: Infantile reflux: Different from adult reflux. Am J Med 1997, 103(5A):114S-119S.
15. Poets CF: Gastroesophageal reflux: A critical review of its role in preterm infants. Pediatrics 2004, 113:128-132.
16. Omari TI, Benninga MA, Barnett CP, et al.: Characterization of esophageal body and lower esophageal sphincter motor function in the very premature neonate. J Pediatr 1999, 135:517-521.
17. Omari TI, Barnett CB, Snel A, et al.: Mechanisms of gastroesophageal reflux in healthy premature infants. J Pediatr 1998, 133:650-654.
18. Omari TI, Barnett CP, Benninga MA, et al.: Mechanisms of gastroesophageal reflux in preterm and term infants with reflux disease. Gut 2002, 51:475-479.
19. Omari T, Snel A, Barnett C, et al.: Measurement of upper esophageal sphincter tone and relaxation during swallowing in premature infants. Am J Physiol 1999, 277:-G862-G866.
20. Omari TI, Miki K, Fraser R, et al.: Esophageal body and lower esophageal sphincter function in healthy premature infants. Gastroenterology 1995, 109:1757-1764.
21. Peter CS, Wiechers C, Bohnhorst B, et al.: Influence of nasogastric tubes on gastroesophageal reflux in preterm infants: a multiple intraluminal impedance study. J Pediatr 2002, 141:277-279.
22. Ewer AK, Durbin CM, Morgan ME, Booth IW: Gastric emptying and gastro-oesophageal reflux in preterm infants. Arch Dis Child Fetal Neonatal Ed 1996, 75:F117-F121.
23. Grant L, Cochran D: Can pH monitoring reliably detect gastroesophageal reflux in preterm infants? Arch Dis Child Fetal Neonatal Ed 2001, 85:F155-F157.
24. Mitchell DJ, McClure BG Tubman TR: Simultaneous monitoring of gastric and oesophageal pH reveals limitations of conventional oesophageal pH monitoring in milk fed infants Arch Dis Child 2001, 84:273-276.
25. Condino AA, Sondheimer J, Pan Z, et al.: Evaluation of infantile acid and nonacid gastroesophageal reflux using combined pH monitoring and impedance measurement. Pediatr Gastroenterol Nutr 2006, 42:16-21.
26. Wenzl TG, Moroder C, Trachterna M, et al.: Esophageal PH monitoring and impedance measurement: a comparison of two diagnostic tests for gastroesophageal reflux. J Pediatr Gastroenterol Nutr 2002, 34:519-523.
27. Vandenplas Y, Salvatore S, Vieira MC, Hauser B: Will esophageal impedance replace pH monitoring? Pediatrics 2007, 119:118-122.
28. Peter CS, Wiechers C, Bohnhorst B, et al.: Detection of small bolus volumes using multiple intraluminal impedance in preterm infants. J Pediatr Gastroenterol Nutr 2003, 36:381-384.
29. Peter CS, Sprodowski N, Ahlborn V, et al.: Inter- and intraobserver agreement for gastroesophageal reflux detection in infants using multiple intraluminal impedance. Biol Neonate 2004, 85:11-14.
30. Consensus Statement: National Institutes of Health consensus development conference on infantile apnea and home monitoring, Sept 29-Oct 1, 1986. Pediatrics 1987, 79:292-299.
31. Martin RJ, Abu-Shaweesh JM: Control of breathing and neonatal apnea Biol Neonate 2005, 87:288-295.
32. Abu-Shaweesh JM: Maturation of respiratory reflex responses in the fetus and neonate. Senmin Nenonatol 2004, 9:169-180.
33. St-Hilaire M, Nsegbe E, Gagnon-Gervais K, et al.: Laryngeal chemoreflexes induced by acid, water, and saline in nonsedated newborn lambs during quiet sleep. J Appl Physiol 2005, 98:2197-2203.
34. Downing SE, Lee JC: Laryngeal chemosensitivity: a possible mechanism for sudden infant death. Pediatrics 1975, 55:640-649.
35. Abu-Shaweesh JM, Dreshaj IA, Haxhiu MA, Martin RJ: Central GABAergic mechanisms are involved in apnea induced by SLN stimulation in piglets. J Appl Physiol 2001, 90:1570-1576.
36. Davies AM, Koenig JS, Thach BT: Characteristics of upper airway chemoreflex prolonged apnea in human infants. Am Rev Respir Dis 1989, 139:668-673.
37. Pickens DL, Schefft G, Thach BT: Prolonged apnea associated with upper airway protective reflexes in apnea of prematurity. Am Rev Respir Dis 1988, 137:113-118.
38. Thompson DM, Rutter MJ, Rodolph CD, et al.: Altered laryngeal sensation: a potential cause of apnea of infancy. Ann Otol Rhinol Laryngol 2005, 114:258-263.
39. Kimball AL, Carlton DP: Gastroesophageal reflux medications in the treatment of apnea in premature infants. J Pediatr 2001, 138:355-360.
40. Haxhiu MS, Erokwu BO, Cherniack NS: The brainstem network involved in coordination of inspiratory activity and cholinergic outflow to the airways. J Auton Nerv Syst 1996, 61:155-161.
41. Haxhiu-Poskurica B, Carlo WA, Miller MJ, et al.: Maturation of respiratory reflex responses in the piglet. J Appl Physiol 1991, 70:608-616.
42. Kiatchoosakun P, Dreshaj IA, Abu-Shaweesh JM, et al.: Effects of hypoxia on respiratory neural output and lower esophageal sphincter pressure in piglets. Pediatr Res 2002, 52:50-55.
43. Hibbs AM, Lorch SA: Metoclopramide for the treatment of gastroesophageal reflux disease in infants: a systematic review. Pediatrics 2006, 118:746-752.
44. Martin RJ, Hibbs AM: Diagnosing gastroesophageal reflux in preterm infants. Pediatrics 2006, 118:793-794.
45. Carroll AE, Garrison MM, Christakis DA: A systematic review of nonpharmacological and nonsurgical therapies for gastroesophageal reflux in infants. Arch Pediatr Adolesc Med 2002, 156:109-113.
46. Craig WR, Hanlon-Dearman A, Sinclair C, et al.: Metoclopramide, thickened feedings, and positioning for gastro-oesophageal reflux in children under two years. Cochrane Database Syst Rev 2004, 4:CD003502.
47. Wenzl TG, Silny J, Schenke S, et al.: Gastroesophageal reflux and respiratory phenomena in infants: status of the intraluminal impedance technique. J Pediatr Gastroenterol Nutr 1999, 28:423-428.