Metoclopramide for the treatment of gastroesophageal reflux disease in infants: A systematic review

Pediatrics

Volumn 118, Issue 2, 2006, Pages 746-752

  Hibbs, Anna Maria ^a   Lorch, Scott A ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b NONE

Author keywords

Gastroesophageal reflux; Infant; Metoclopramide; Systematic reviews

Indexed keywords

METOCLOPRAMIDE; PLACEBO;

APNEA; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DROWSINESS; DRUG EFFICACY; DRUG OVERDOSE; DYSTONIA; GASTROESOPHAGEAL REFLUX; HUMAN; IRRITABILITY; MEDLINE; META ANALYSIS; OCULOGYRIC CRISIS; PH MEASUREMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; RISK FACTOR; SCORING SYSTEM; SIDE EFFECT; SINGLE DRUG DOSE; STOMACH EMPTYING; SYSTEMATIC REVIEW; TREATMENT OUTCOME; VOMITING; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; INFANT; METHODOLOGY; PROSPECTIVE STUDY; SINGLE BLIND PROCEDURE;

DOUBLE-BLIND METHOD; DYSTONIA; GASTROESOPHAGEAL REFLUX; HUMANS; INFANT; IRRITABLE MOOD; METOCLOPRAMIDE; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS; RESEARCH DESIGN; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 33748434509     PISSN: 00314005     EISSN: 02105721     Source Type: Journal    
DOI: 10.1542/peds.2005-2664     Document Type: Review

References (34)

1. Nelson SP, Chen EH, Syniar GM, Christoffel KK. Prevalence of symptoms of gastroesophageal reflux during infancy: a pediatric practice-based survey. Pediatric Practice Research Group. Arch Pediatr Adolesc Med. 1997;151:569-572
2. Gold BD. Outcomes of pediatric gastroesophageal reflux disease: in the first year of life, in childhood, and in adults . . . oh, and should we really leave Helicobacter pylori alone? J Pediatr Gastroenterol Nutr. 2003;37(suppl 1):S33-S39
3. Kohelet D, Boaz M, Serour F, Cohen-Adad N, Arbel E, Gorenstein A. Esophageal pH study and symptomatology of gastroesophageal reflux in newborn infants. Am J Perinatol. 2004;21:85-91
4. Rudolph CD, Mazur LJ, Liptak GS, et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 2001;32(suppl 2):S1-S31
5. Barrington KJ, Tan K, Rich W. Apnea at discharge and gastroesophageal reflux in the preterm infant. J Perinatol. 2002;22:8-11
6. Dhillon AS, Ewer AK. Diagnosis and management of gastrooesophageal reflux in preterm infants in neonatal intensive care units. Acta Paediatr. 2004;93:88-93
7. Di Fiore JM, Arko M, Whitehouse M, Kimball A, Martin RJ. Apnea is not prolonged by acid gastroesophageal reflux in preterm infants. Pediatrics. 2005;116:1059-1063
8. Molloy EJ, Di Fiore JM, Martin RJ. Does gastroesophageal reflux cause apnea in preterm infants? Biol Neonate. 2005;87:254-261
9. Poets CF. Gastroesophageal reflux: a critical review of its role in preterm infants. Pediatrics. 2004;113(2). Available at: www.pediatrics.org/cgi/content/full/113/2/e128
10. Hyams JS, Leichtner AM, Zamett LO, Walters JK. Effect of metoclopramide on prolonged intraesophageal pH testing in infants with gastroesophageal reflux. J Pediatr Gastroenterol Nutr. 1986;5:716-720
11. Hyman PE, Abrams C, Dubois A. Effect of metoclopramide and bethanechol on gastric emptying in infants. Pediatr Res. 1985;19:1029-1032
12. Hyman PE, Abrams CE, Dubois A. Gastric emptying in infants: response to metoclopramide depends on the underlying condition. J Pediatr Gastroenterol Nutr. 1988;7:181-184
13. Kearns GL, Butler HL, Lane JK, Carchman SH, Wright GJ. Metoclopramide pharmacokinetics and pharmacodynamics in infants with gastroesophageal reflux. J Pediatr Gastroenterol Nutr. 1988;7:823-829
14. Leung AKC, Lai PCW. Use of metoclopramide for the treatment of gastroesophageal reflux in infants and children. Curr Ther Res Clin Exp. 1984;36:911-915
15. Machida HM, Forbes DA, Gall DG, Scott RB. Metoclopramide in gastroesophageal reflux of infancy. J Pediatr. 1988;112:483-487
16. Rode H, Stunden RJ, Millar AJ, Cywes S. Esophageal pH assessment of gastroesophageal reflux in 18 patients and the effect of two prokinetic agents: cisapride and metoclopramide. J Pediatr Surg. 1987;22:931-934
17. Sankaran K, Yeboah E, Bingham WT, Ninan A. Use of metoclopramide in preterm infants. Dev Pharmacol Ther. 1982;5:114-119
18. Tolia V, Calhoun J, Kuhns L, Kauffman RE. Randomized, prospective double-blind trial of metoclopramide and placebo for gastroesophageal reflux in infants. J Pediatr. 1989;115:141-145
19. Shaffer D, Butterfield M, Pamer C, Mackey AC. Tardive dyskinesia risks and metoclopramide use before and after U.S. market withdrawal of cisapride. J Am Pharm Assoc (Wash DC). 2004;44:661-665
20. Mejia NI, Jankovic J. Metoclopramide-induced tardive dyskinesia in an infant. Mov Disord. 2005;20:86-89
21. Madani S, Tolia V. Gynecomastia with metoclopramide use in pediatric patients. J Clin Gastroenterol. 1997;24:79-81
22. Leary PM. Adverse reactions in children: special considerations in prevention and management. Drug Saf. 1991;6:171-182
23. Kaplan S; Department of Health and Human Services; Public Health Service; Food and Drug Administration; Center for Drug Evaluation and Research. Metoclopramide: drug use data review (Myzan, NDA 21-645). 2005. Available at: www.fda.gov/ohrms/dockets/ac/05/briefing/2005-4167B1_02_11-FDA-Tab11-Review.pdf. Accessed June 9, 2006
24. Craig WR, Hanlon-Dearman A, Sinclair C, Taback S, Moffatt M. Metoclopramide, thickened feedings, and positioning for gastro-oesophageal reflux in children under two years. Cochrane Database Syst Rev. 2004(4):CD003502
25. Harris RP, Helfand M, Woolf SH, et al. Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med. 2001;20(3 suppl):21-35
26. Badriul H, Vandenplas Y. Gastro-oesophageal reflux in infancy. J Gastroenterol Hepatol. 1999;14:13-19
27. Brown P. Medical management of gastroesophageal reflux. Curr Opin Pediatr. 2000;12:247-250
28. Orenstein SR. Management of supraesophageal complications of gastroesophageal reflux disease in infants and children. Am J Med. 2000;108(suppl 4a):139S-143S
29. Sandritter T. Gastroesophageal reflux disease in infants and children. J Pediatr Health Care. 2003;17:198-205; quiz 204-205
30. Taminiau JA. Gastro-oesophageal reflux in children. Scand J Gastroenterol Suppl. 1997;223:18-20
31. Vandenplas Y, Belli D, Benhamou P, et al. A critical appraisal of current management practices for infant regurgitation: recommendations of a working party. Eur J Pediatr. 1997;156:343-357
32. Bellissant E, Duhamel JF, Guillot M, Pariente-Khayat A, Olive G, Pons G. The triangular test to assess the efficacy of metoclopramide in gastroesophageal reflux. Clin Pharmacol Ther. 1997;61:377-384
33. Kimball AL, Carlton DP. Gastroesophageal reflux medications in the treatment of apnea in premature infants. J Pediatr. 2001;138:355-360
34. Pons G, Duhamel JF, Guillot M, et al. Dose-response study of metoclopramide in gastroesophageal reflux in infancy. Fundam Clin Pharmacol. 1993;7:161-166