Efficacy and Safety of Enoxaparin Versus Unfractionated Heparin in Patients With ST-Segment Elevation Myocardial Infarction Also Treated With Clopidogrel

Journal of the American College of Cardiology

Volumn 49, Issue 23, 2007, Pages 2256-2263

  Sabatine, Marc S ^a   Morrow, David A ^a   Dalby, Anthony ^b   Pfisterer, Mathias ^c   Duris, Tibor ^d   Lopez Sendon, Jose ^e   Murphy, Sabina A ^a   Gao, Runlin ^f   Antman, Elliott M ^a   Braunwald, Eugene ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MILPARK HOSPITAL   (South Africa)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d FNsP ^*  (Slovakia)

^e HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^f FUWAI HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENOXAPARIN; FIBRINOLYTIC AGENT; HEPARIN; STATINE DERIVATIVE;

AGED; ARTICLE; BLEEDING; BRAIN HEMORRHAGE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; FEMALE; FIBRINOLYTIC THERAPY; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; REPERFUSION; RISK REDUCTION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TREATMENT OUTCOME;

AGED; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ENOXAPARIN; FEMALE; FIBRINOLYTIC AGENTS; HEPARIN; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PLATELET AGGREGATION INHIBITORS; THROMBOLYTIC THERAPY; TICLOPIDINE; TREATMENT OUTCOME;

EID: 34249865378     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2007.01.092     Document Type: Article

References (13)

1. Antman E.M., Anbe D.T., Armstrong P.W., et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). Circulation 110 (2004) e82-e292
2. Antman E.M. The search for replacements for unfractionated heparin. Circulation 103 (2001) 2310-2314
3. Antman E.M., Morrow D.A., McCabe C.H., et al. Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. N Engl J Med 354 (2006) 1477-1488
4. Sabatine M.S., Cannon C.P., Gibson C.M., et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 352 (2005) 1179-1189
5. Chen Z.M., Jiang L.X., Chen Y.P., et al. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 366 (2005) 1607-1621
6. Antman E.M., Morrow D.A., McCabe C.H., et al. Enoxaparin versus unfractionated heparin as antithrombin therapy in patients receiving fibrinolysis for ST elevation MI: design and rationale for the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment Thrombolysis in Myocardial Infarction-Study 25 (ExTRACT-TIMI 25). Am Heart J 149 (2005) 217-226
7. Bovill E.G., Terrin M.L., Stump D.C., et al. Hemorrhagic events during therapy with recombinant tissue-type plasminogen activator, heparin, and aspirin for acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI), Phase II trial. Ann Intern Med 115 (1991) 256-265
8. Morrow D.A., Antman E.M., Charlesworth A., et al. TIMI risk score for ST-elevation myocardial infarction: a convenient, bedside, clinical score for risk assessment at presentation: an Intravenous NPA for Treatment of Infarcting Myocardium Early II trial substudy. Circulation 102 (2000) 2031-2037
9. The TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. N Engl J Med 312 (1985) 932-936
10. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet ii (1988) 349-360
11. The GUSTO Investigators. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 329 (1993) 673-682
12. Eikelboom J.W., Quinlan D.J., Mehta S.R., Turpie A.G., Menown I.B., and Yusuf S. Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: a meta-analysis of the randomized trials. Circulation 112 (2005) 3855-3867
13. Sabatine M.S., Morrow D.A., Montalescot G., et al. Angiographic and clinical outcomes in patients receiving low-molecular-weight heparin versus unfractionated heparin in ST-elevation myocardial infarction treated with fibrinolytics in the CLARITY-TIMI 28 trial. Circulation 112 (2005) 3846-3854